By streamlining our NGS panels to reflect the fast-growing knowledge of complex gene-disease associations, CENTOGENE’s NGS Panels represent start-of-the-art research – providing fast, thorough, and cost-effective diagnostic solutions for patients and their families.
Diagnosing a genetic disorder often requires analyzing multiple genes. We have designed our NGS panels to simultaneously test multiple genes associated with a particular disorder or group of disorders. Additionally, our panels include all relevant pathogenic and likely pathogenic variants (class 1 and class 2) within coding regions, regulatory sequences, and deep intronic regions. We use all publicly available databases such as HGMD and unpublished variants included in our rare disease-centric Bio/Databank to establish a diagnosis. We provide high-quality sequencing and best-in-class data analysis - interpreted and communicated in comprehensive medical reports.
When choosing one of our NGS panels, your patients will receive high-quality sequencing, best-in-class data analysis and interpretation as well as comprehensive medical reports – significantly simplifying the diagnostic process for you and your patients.
Why Choose our NGS Panels?
Easy sample submission with CentoCard®
High quality clinical interpretation powered by CENTOGENE's rare disease-centric Bio/Databank
Quick turnaround time and the strictest quality criteria
User-friendly, online ordering and tracking with CentoPortal®
NGS Panels are recommended for patients meeting any or multiple of the following criteria:*
- Distinctive clinical features
- Family history of a particular disorder
- Multiple genes linked to condition
- Genetically heterogeneous disorders
- Well-defined disease-associated genes
* Genet Med. 2015 Jun;17(6):444-51. doi: 10.1038/gim.2014.122. Epub 2
- Interpretation of data by experienced professionals
- Clear results of identified variants following international best-practice guidelines (ACMG and CMSS)
- Detailed method description
- References to publications supporting medical and scientific results
- Recommendations for follow-up analyses for specific diseases
- Reporting of pathogenic variants, likely pathogenic variants and VUS
Pathogenic and likely pathogenic variants are reported following ACMG classification guidelines. Variants of uncertain significance (VUS) are not reported in any of the following cases: the described phenotype(s) is explained by detected pathogenic or likely pathogenic variant(s); the detected VUS are not related to the described phenotype(s) of the patient or family members; in the lack of sufficient clinical information; and in our oncogenetic panels.
Please note that detailed and specific clinical information (preferentially phenotype/HPOs) is required for variant interpretation and medical diagnosis.
NEW CentoXome®: convirtiendo nuestra experiencia en su ventaja
Los oradores del webinar, la Dra. Pilar Guatibonza, Clinical Genetic Liaison CENTOGENE, y el Dr. Carlos Manrique, Gerente Regional de Ventas en México CENTOGENE, discuten el poder del NEW CentoXome […]
- Metabolic Disorders
NEW CentoXome® – Turning Our Expertise Into Your Advantage
Dr. Aida Bertoli-Avella and Dr. Jorge Pinto-Pasto provide you with an exclusive look into our enhanced Whole Exome Sequencing (WES) solution – NEW CentoXome.
- Mutation Database
NEW CentoXome – Turning Years Into Days
Throughout the CentoTalk, Maximilian Schmid, M.D., and Jorge Pinto Basto, M.D., will provide a detailed overview of CENTOGENE’s new and enhanced Whole Exome Sequencing (WES) solution.
- Mutation Database