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Scientific Publications

Science combined with clinical diagnostics enhances common knowledge to the benefit of the medical community. Explore our findings and stay informed about the latest discoveries.

Mechanistic Insights Into Cancer Predisposition

Genetic predisposition to cancer is tightly linked to an increased rate of somatic mutations. For one of the corresponding syndromes, the underlying defect has now been revealed to affect the DNA […]

Article
Aug 26, 2020
  • Mutation Database
  • Oncology
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Understanding DNA Alterations in Colorectal Cancer

Germline and somatic DNA alterations may cause inherited diseases and/or cancer. While CENTOGENE’s routine diagnostic focus is on the former, we frequently address oncological questions in research […]

Article
Dec 18, 2019
  • Oncology
  • WES
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Genetic modifiers in hereditary breast cancer

Age at manifestation varies widely in carriers of cancer susceptibility variants. A recent study involving scientists from CENTOGENE suggested that this phenomenon is partially explained by certain […]

Article
Aug 07, 2019
  • Oncology
  • Mutation Database
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Robustness of Comprehensive DNA- and RNA-Based Assays at Diagnosis of Acute Myeloid Leukemia Using Blood and Bone Marrow Stored on Filter Cards

"Molecular analyses in hematologic malignancies gained considerable importance in the last decade at diagnosis and for minimal residual disease (MRD). In our study, we performed a comparison of […]

Article
Jul 12, 2016
  • Hematology
  • Oncology
  • CentoCard®
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Characterization of the Novel Indolylmaleimides'

Protein kinase inhibitors are widely used in chemotherapeutic cancer regimens. Maleimide derivatives such as SB-216763 act as GSK-3 inhibitor targeting cell proliferation, cell death and cell cycle […]

Article
May 11, 2016
  • Oncology
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Next-Generation Sequencing of the BRCA1 and BRCA2 Genes for the Diagnostics of Breast and/or Ovarian Cancer

We explored a more efficient genetic screening strategy based on next-generation sequencing of the BRCA1 and BRCA2 genes in 210 hereditary breast and/or ovarian cancer patients.

Article
Mar 01, 2015
  • Oncology
  • NGS
  • BRCA 1/2
  • Hereditary Cancer
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‘Omics’ and ‘Omes’ – The Future of Personalised Medicine

Advanced treatment – tailored to the individual patient instead of “one-size-fits-all” – is the zenith of personalized, or precision, medicine.

Article
Dec 31, 2014
  • Oncology
  • Biomarker
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The Novel Arylindolylmaleimide PDA-66 Displays Pronounced Antiproliferative Effects in Acute Lymphoblastic Leukemia Cells

PDA-66 displays significant antileukemic activity in ALL cells and classifies as candidate for further evaluation as a potential drug in targeted therapy of ALL.

Article
Feb 05, 2014
  • Oncology
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