Mechanistic Insights Into Cancer Predisposition

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion

Genetic predisposition to cancer is tightly linked to an increased rate of somatic mutations. For one of the corresponding syndromes, the underlying defect has now been revealed to affect the DNA replication process. This insightful discovery, which involved researchers from CENTOGENE, was published in Nature Communications, one of the leading journals in the field of life sciences.


  • Janne J M van Schie
  • et al.