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Microarray Testing with CentoArray®

Extensive genome-wide cytogenetic analysis. For early and accurate answers.

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Chromosomal Microarray Analysis With CentoArray

Cytogenic variations are known to cause a broad range of developmental disorders, primarily neurodevelopmental and congenital anomalies.

Chromosomal microarray analysis (CMA) is recommended for analyzing cytogenic variations in patients suffering for unexplained developmental delays, intellectual disabilities, autism spectrum disorders, and/or multiple congenital malformations.

CENTOGENE’s microarray-based solution – CentoArray – enables the genome-wide detection of known novel structural aberrations, copy number variations (CNVs), chromosomal imbalances, regions exhibiting loss/absence of heterozygosity (LOH), uniparental isodisomy (UPD), and mosaicism.

Why Choose CentoArray?

Built on the latest genetic and medical insights 

Covering more than 4,800 cytogenetic relevant genes with exon level resolution

Attractive price

Short turnaround time 

CentoArray – Key Advantages

high resolution and broad coverage

Optimized probe spacing, focusing on exonic regions to provide the best cytogenetic disease variant coverage 

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Disease-focused content 

Platform designed to represent latest clinical and genetic insights with more than 4,800 cytogenic relevant genes based on ClinGen, DDG2P, ClinVar, PharmGKB, NHGRI-EBI, and GWAS database

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Quality analysis with a wide range of sample types

Delivering high-quality analysis via a wide range of samples including CentoCard®, EDTA blood, ready to use DNA, buccal swab, chronic villi, and amniotic fluid

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CentoPortal® is a user-friendly, online, web-based ordering portal designed to assist you at every step of processing your patients' samples.

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When is CentoArray Recommended?

  • As a first-step analysis for cases of unexplained developmental delays, intellectual disabilities, autism spectrum disorders, and/or multiple congenital malformations
  • For deletion/duplication analysis of extremely large genes where gross deletions involving large segments of genes, flanking intergenic regions, or neighboring genes are frequently reported
  • To diagnose uniparental disomy (UPD) and regions exhibiting loss/absence of heterozygosity (LOH)
  • In conjunction with whole exome sequencing (CentoXome) to complement large CNVs. CentoArray can be ordered either as a step-wise analysis after CentoXome or together as a single-step approach
  • For prenatal testing to help determine a cause of ultrasound-detected abnormalities via CentoArray Prenatal

Features & Performance

Characteristics Genome-wide cytogenetic analysis to detect structural aberrations, such as CNVs, chromosomal imbalances, LOH, UPD, and mosaicism
Total markers (polymorphic) 1.8 Million SNP markers
Resolution of CNVs detection >25kb for copy number loss
>200kb for copy number gain
Detection of AOH/LOH >10 Mb
Mosaicism detection Down to 30%
Exon level resolution for ~4800 cytogenic relevant genes
Sample Types CentoCard, EDTA-blood, ready to use DNA, buccal swab, amniotic fluid, chorionic villi, cord blood, and tissue and biopsy
TAT 15 business days

Useful Links

Related Webinar

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