CENTOGENE Holding the Hand of an Elderly Lady

Somatic Mutation Testing for Myeloid Tumors

Genetic testing for myeloid tumor at CENTOGENE can provide you with valuable information for diagnostic decisions, prognosis, therapeutic approaches and patient counseling

Order a test  Learn more

Myeloid Tumor Panel – Somatic Mutation Testing

The myeloid tumor panel targets important regions within 35 genes that are frequently mutated in myeloid malignancies. Myeloid malignancies are clonal diseases of hematopoietic progenitor cells.  Myeloid tumors represent the fourth most frequently diagnosed cancer in economically developed countries.

Benefits of myeloid tumor panel genetic testing
  • Enables rapid eligibility identification and patient stratification for clinical trials
  • Allows longitudinal and serial molecular monitoring throughout the clinical trial process
  • Can be conducted with fresh or frozen/archived blood and bone marrow samples
  • Does not require special shipping or storage provisions
  • Employs expert analysis from a CLIA-certified lab
  • Identifies patients at high risk who are less likely to respond well to treatment
  • Helps to determine the intensity of treatment each patient should receive

CENTOGENE's myeloid tumor panel offers:

  • Our comprehensive myeloid tumor panel includes library preparation, sequencing, and data analysis and reporting in a cost-effective way and with a turnaround time of only ten days
  • Myeloid tumor panel collectively assesses important regions within 22 genes with high accuracy, high sensitivity and at a mean coverage depth of >1,000x
  • Myeloid tumor panel enables clinical researchers and physicians to access expert-defined content to investigate genomic features associated with hematological malignancies
  • Myeloid tumor panel utilizes NGS sequencing and Illumina Platform

The goals of somatic testing of myeloid tumors

  • Myeloid tumors that may respond to targeted therapies by assessing multiple gene targets simultaneously
  • Specific mutations within genes known to be associated with response or resistance to specific cancer therapies
  • Mutations that may help determine prognosis for patients with myeloid tumors
  • The best therapeutic strategy for each patient
  • The diagnosis that will reassure both patient and physician about the relevant health problem and all the possible solutions to improve it

Visit Our Online Ordering Portal

CentoPortal® is a user-friendly, online, web-based ordering portal designed to assist you at every step of processing your patients' samples.

Go to CentoPortal

CENTOGENE CentoPortal Logo

Creating the mutational profile of myeloid tumors

The majority of myeloid tumors contain high numbers of somatic mutations, which are genetic changes that are not inherited but created within the tumor itself. Unlike inherited “germline” mutations these somatic mutations are not transmitted to offspring.

Somatic mutations significantly contribute to the pathogenesis, progression and prognosis of myeloid malignancies. Whole genome sequencing in several patients with myeloproliferative disorders pointed at several genes and variants, clearly associated in patients affected with myeloproliferative syndromes.

Genes which affect classification and prognosis of acute myeloid leukemias are FLT3, NPMT1, CEBPA. Recently IDH1 and also IDH2 have shown evidence to be informative as diagnostic markers. Additional genes are KIT, TP53, ASXL1, ATRX and SETBP1.

Who can be offered the myeloid tumor panel?

  • Individuals with myeloid tumor: acute myeloid leukemia (AML), chronic myeloid leukemia (CML), myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML). The results of this genetic test can be useful for assessing the prognosis and guiding the treatment of individuals with myeloid malignancies
  • Patients without clinical diagnosis but with classical clinical symptoms and possible changes in the blood cells morphology and counts
  • Individuals with early stage disease where a mutational profile from multiple genes informs diagnosis or disease stratification, prognosis, and treatment options
  • For late-stage cancers, the test is designed to evaluate options for alternative treatments, including targeted therapies
Gene test

Myeloid tumor panel

Gene names

ASXL1, ATM, CBL, CDKN2A, CEBPA, CREBBP, DNMT3A, ETV6, EZH2, FLT3, GATA2, HRAS, IDH1, IDH2, JAK2, KIT, KRAS, NF1, NOTCH1, NPM1, NRAS, PDGFRB, PHF6, PTPN11, RAD21, RUNX1, SF3B1, SMC1A, SMC3, SRSF2, STAG2, TET2, TP53, U2AF1, WT1

Diseases covered Acute myeloid leukemia (AML), chronic myeloid leukemia (CML), myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML)
Turnaround time 10 business days
How to order Order a test

Resources

Downloads

Product Sheets

CENTOGENE Myeloid Productsheet English PDF

Myeloid Tumor Panel – Product Sheet

The targeted approach to detecting myeloid malignancies

Scientific Publications

Mechanistic Insights Into Cancer Predisposition

Genetic predisposition to cancer is tightly linked to an increased rate of somatic mutations. For one of the corresponding syndromes, the underlying defect has now been revealed to affect the DNA […]

Article
Aug 26, 2020
  • Mutation Database
  • Oncology
Loading...

Understanding DNA Alterations in Colorectal Cancer

Germline and somatic DNA alterations may cause inherited diseases and/or cancer. While CENTOGENE’s routine diagnostic focus is on the former, we frequently address oncological questions in research […]

Article
Dec 18, 2019
  • Oncology
  • WES
Loading...

Genetic modifiers in hereditary breast cancer

Age at manifestation varies widely in carriers of cancer susceptibility variants. A recent study involving scientists from CENTOGENE suggested that this phenomenon is partially explained by certain […]

Article
Aug 07, 2019
  • Oncology
  • Mutation Database
Loading...
Doctor and woman look down

Single-Gene-Specific Somatic Mutation Testing

CENTOGENE's somatic mutation tests are highly sensitive, easy to use, and accurate for identifying even low frequency variants successfully.

Learn more

Get in Touch With Our Customer Support

Our consultation service is available in several languages.

+49 (0) 381 80 113 - 416

Mon. – Fri. 7 a.m. – 8 p.m. CEST

Sat. 8 a.m. – 12 p.m. CEST

Contact Us

For our US Partners:

+1 (617) 580 - 2102

Mon. – Fri. 9 a.m. – 5:30 p.m. EST


Contact Us