CentoArray - Comparative Genomic Hybridization (CGH)

Comparative genomic hybridization (CGH) is a molecular cytogenetic technique for analyzing copy number variations. Array CGH (aCGH) allows us to quickly and efficiently determine the relative abundance of nucleic acid sequences in the target sample. The method utilizes a large number of short stretches of synthetic DNA that probe for various genomic loci dispersed throughout the genome. The target DNA sample is labeled and hybridized against DNA probes spotted on a solid array surface. Based on the relative amount of probe hybridized to each target spot, information is gained about the abundance of specific nucleic acid sequences within the sample. The major advantage of high density genomic arrays in detecting structural aberrations is that they can provide information on thousands of targets in a single experiment resolving any copy number changes at gene, chromosome or genome level. Typically, a high number of probes in the coding region of genes combined with backbone probes in the non-coding regions, enables detection of both previously described and novel alterations in regions of interest. When copy number probes are combined with SNP probes at high density, additional information on mosaicism, loss of heterozygosity (LOH) and uniparental disomy (UPD) can be gained.

Discover our CentoArray microarray solutions:

CENTOGENE’s CentoArrayCyto is specially designed to give the best possible results in cytogenetic and oncogenetic testing respectively.

Advantages of our CentoArray solutions:

  • Highest resolution of chromosomal aberrations at the genome level
  • Short turnaround time (15 business days)
  • Highest performance with a wide range of sample types including formalin fixed paraffin embedded (FFPE) specimen
  • Offered at an attractive price, CentoArray is a cost effective alternative to MLPA and qPCR when analyzing multiple genes simultaneously
  • CAP, CLIA and ISO accreditation