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CentoICU – For the Earliest and Fastest Diagnosis

For the earliest and fastest diagnosis of critically ill newborns and children under 24 months in intensive care units (ICU).

CentoICU is designed to diagnose genetic conditions that manifest in newborns or in early childhood. Many of these conditions have overlapping phenotypes and diagnosis may have immediate implications for the treatment.

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What Is CentoICU?

Newborns and children under 24 months presenting with life-threatening conditions need a fast and precise diagnosis to ensure rapid and efficient further diagnostic and therapeutic initiation.

Up to one-third of all babies and children admitted to the ICU have a genetic disease. For many of them early identification can make the difference for their immediate and later health.

CentoICU is a comprehensive NGS panel that includes more than 850 genes, explicitly selected for the genetic testing of critically ill newborns and children under 24 months. It is designed to address multiple genetic conditions that may present in the newborn or first childhood period, many with overlapping phenotypes and immediate implications for treatment initiation. It allows clinicians to utilize just one single test to provide an accurate diagnosis of newborn-related diseases.

Why Choose CentoICU?

Minimal sample requirement (just 0.5 ml blood, 1 µg DNA or 1 filter card)

Screening of more than 850 genes associated with over 100 conditions

Short turnaround times – ten business days is possible

World-class medical reports interpreted by expert human geneticists

What Are the Advantages of CentoICU?

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Turn around time

Short TATs: 10 business days (CentoICU FAST) or 15 business days (CentoICU)

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Add-on

Option to add CentoArrayCyto® to complement copy number analysis

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coding regions

Comprehensive coverage of coding regions known to cause diseases in newborns

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Specialized technology

Screens newborns for all ACMG-recommended conditions and those nominated for inclusion.

Visit Our Online Ordering Portal

CentoPortal® is a user-friendly, online, web-based ordering portal designed to assist you at every step of processing your patients' samples.

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When Is CentoICU Recommended?

CentoICU allows clinicians to utilize one test to provide an accurate assessment for newborn-related genes and associated genetic diseases using dried blood spots, and it provides fast delivery of the results in less than 15 business days.

CentoICU is indicated for newborns and children under 24 months admitted to the ICU and presenting with unclear symptomatology which can be part of a genetic condition, i.e.

  • Bleeding dyathesis
  • Blood abnormalities (anemia)
  • Bone fragility
  • Failure to thrive
  • Heart abnormality/arrhythmia
  • Hepatospenomegaly
  • Hypotonia
  • Ichthyosis/epidermolysis bullosa
  • Metabolic abnormalities*
  • Microcephaly
  • Neutropenia
  • Abnormal newborn screening results**
  • Respiratory failure
  • Skeletal abnormalities/craniosynostosis
  • Skin fragility
  • Unclear seizures

*) Abnormal acylcarnitine profile, amino acidemia/urea, hyperbilirubinemia, hyper-/hypoinsulinism, persistent hypoglycemia, organic acidemia/urea
**) CentoICU  includes genes to cover all ACMG core panel phenotypes for newborn screening except hearing loss

Disorders With Potential Direct Therapeutic Consequences

Disorder* Genes
Alagille syndrome NOTCH2, JAG1
Alpha-Thalassemia HBA1, HBA2
Arginase deficiency ARG1
Beta-Thalassemia HBB
Biotinidase deficiency BTD
Biotin-thiamine-responsive basal ganglia disease SLC19A3
Carnitine deficiency SLC22A5
Cystic Fibrosis CFTR
Dystonia DOPA responsive GCH1
Factor VII deficiency F7
Glucose transporter 1 deficiency SLC2A1
Glutaric acidemia Type 1 GCDH
Hemophilia A F8**
Hemophilia B F9
Hereditary Fructose intolerance ALDOB
Holocarboxylase synthetase deficiency HLCS
Maple syrup urine disease (MSUD) BCKDHA, BCKDHB, DBT
Non ketotic hyperglicinemia GLDC
Phenylketonuria PAH
Pompe disease GAA
Primary coenzyme Q10 deficiency COQ8A
Pyridoxamine 5 phosphate oxidase deficiency PNPO
Pyridoxine-dependent epilepsy ALDH7A1
Pyruvate carboxylase deficiency PC
Tuberous sclerosis complex TSC1
Tuberous sclerosis complex TSC2
Tyrosinemia Type I FAH
VLCAD deficiency ACADVL

*List does not include all disorders covered by our panel
**This panel does not detect intronic inversions for F8

What Genes Are Included in CentoICU?

CentoICU is designed for analysis more than 850 genes associated with over 100 conditions. The list of included genes was developed by our expert medical team based on several selection criteria, i.e.:

  • Early onset
  • Severe disease
  • ICU related symptomatology
  • Diseases/syndromes of differential diagnostic value

Full list of genes

Resources

Downloads

CENTOGENE CentoICU Brochure English PDF

CentoICU Brochure

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