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How to Order a Genetic Test

All you need to know to find and order your genetic test at CENTOGENE.

  1. How to Order

How to Order

Sample requirements

Our techniques are developed for the optimal use of all clinical materials. We are aware of the importance of these samples and we pay utmost attention to their careful and efficient preparation. Depending on which test you select, we accept the following materials:

Material requirements


CentoCard® / Filtercard

  • ≥ 1 CentoCard® (10 complete blood spots)

Exceptions:

  • CentoLSD Enzyme Panel and CentoLSD Enzyme Panel X-TRA require 2 full CentoCards® (2x10 blood spots)

EDTA blood

  • ≥ 1 ml

      Exceptions:

  • CentoLSD Enzyme panel and CentoLSD Enzyme panel X-TRA ≥ 2ml;
  • Biochemical testing: For arylsulfatase A and beta-glucosidase from leucocytes - ≥ 5ml 

Buccal swab

  • 1 Oragene OCR-100 buccal swab collection set

Saliva

  • 1 Oragene OG-510 saliva collection set

 

Ready to use DNA

  • ≥ 1 µg


cfDNA (cell-free DNA)

  • 10 ml of blood shipped in cell-free DNA BCT STRECK tubes

ctDNA (circulating-tumor DNA)

  • 10 ml of blood shipped in cell-free DNA BCT STRECK tubes

Cultured cells

(fibroblasts, chorionic villi calls, amniotic fluid cells)

  • 1 flask, min. 25cm2, 80-90% confluent


CVS (chorionic villi)

  • A minimum of 10 cleaned villi

 

Cord blood

  • ≥1 ml

Amniotic fluid

  • A minimum of 10 ml

Biopsy material

  • Volume 0.5 cm2 or 50 mg

Bone marrow aspirate (NH4-Heparin)

  • ≥ 1 ml

Tissue sample

  • Sample size: ≥20 mg

FFPE (Formaline-fixed Parafin Embedded Tissue)

  • 1 Block
  • ≥10 sections of 10µm thickness (uncharged slides without additives) and control slide with clearly marked area of enriched tumor

Notes:

  1. Each accompanied by Pathology report;
  2. Fixation types accepted: 10% Formalin or 4% Paraformaldehyde or frozen tissue from OCT-Cell blocks (freshly frozen);
  3. Please do not send tissue fixed in Bouins or gluteraldehyde. All samples should be shipped in a sterile tube at room temperature - no cold pack is required.

Please take care that all clinical materials are collected with the highest level of attention. This is of particular importance when sampling fibroblasts, amniotic fluid, or chorionic villi where a sterile environment has to be maintained.

Required sample identification & information

The following information has to be included on the accompanying requisition forms:

  • Patient demographics
  • Ordering physician/ healthcare provider with complete contact details
  • Report recipient with complete contact details
  • Invoice recipient with complete contact details if differing from report recipient
  • Clinical and family history information must be submitted
  • Testing requested
  • Signed, completed consent form
  • Preferred payment option - checking the appropriate box. Please find the payment options and required forms here.

Sample material must be labeled with:

  • Patient’s full name
  • Patient’s date of birth

Important: For all countries outside of Germany, we require a written and signed statement including the complete address and name of the person or institution who will cover the costs of the analysis.


Please note that an e-mail notification needs to be sent to CENTOGENE (customer.support(at)centogene(dot)com) when a time-sensitive specimen has been sent.


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Sample transport

Filtercards, EDTA blood, cord blood, saliva, DNA or paraffin embedded tissue:
Samples can be sent via regular mail at room temperature. Liquid blood is stable for up to 4 days during transport.

Amniotic fluid:
A min. of 10 ml of samples are placed into a sterile conical tube. These should be shipped overnight at room temperature. Care must be taken to ensure that the sample does not freeze.


Chorionic villi, tissue samples other than paraffin embedded tissue:
Specimens need to be shipped at room temperature in a minimum of 35ml of RPMI transport medium with fetal calf serum. Especially during winter months, please ensure that the samples are shipped in a manner to secure that they do not freeze (temperatures should not fall below +4°C).


Cultured cells
Flasks containing cells should be completely filled with transport medium containing fetal calf serum and shipped at room temperature. Care must be taken to ensure that the sample does not freeze.

Blood for ctDNA analysis:
Blood samples must be sent in glass STRECK tubes as per the manufacturer’s recommendation. Samples must be shipped immediately after sampling and at no stage should they be frozen. Blood samples collected in STRECK tubes can be shipped at room temperature, as they are stable up to 14 days. Samples in glass STRECK tubes must be handled and shipped carefully to prevent any damage to the glass tubes during shipment.

More information


Shipping instructions

Samples should be sent to:

CENTOGENE AG
Am Strande 7
18055 Rostock
GERMANY


Get in touch with our Partner Support

Our consultation service is available in several languages.

+49 (0) 381 - 80113 416

Mon. – Fri. 7 a.m.– 8 p.m. CET • Sat. 9 a.m – 5 p.m. CET

For our US Partners:

+1 (617) 580-2102

Mon. – Fri. 9 a.m. – 5.30 p.m. EST