Modifiers of Genetic Disease

Identifying genetic modifiers of age-associated penetrance in X-linked dystonia-parkinsonism

Therapeutic strategies for monogenic diseases may be derived from the identification and understanding of disease-modifying factors. Researchers at CENTOGENE have been applying this rather novel approach, including in collaborative settings with academic colleagues from institutions around the world. A proof-of-concept study resulting from one such collaboration has now been published in Nature Communications.


  • Björn-Hergen Laabs
  • et al.