Cytogenic variations are known to cause a broad range of developmental disorders, primarily neurodevelopmental and congenital anomalies.
Chromosomal microarray analysis (CMA) is recommended for analyzing cytogenic variations in patients suffering for unexplained developmental delays, intellectual disabilities, autism spectrum disorders, and/or multiple congenital malformations.
CENTOGENE’s microarray-based solution – CentoArray – enables the genome-wide detection of known novel structural aberrations, copy number variations (CNVs), chromosomal imbalances, regions exhibiting loss/absence of heterozygosity (LOH), uniparental isodisomy (UPD), and mosaicism.
Built on the latest genetic and medical insights
Covering more than 4,800 cytogenetic relevant genes with exon level resolution
Attractive price
Short turnaround time
Optimized probe spacing, focusing on exonic regions to provide the best cytogenetic disease variant coverage
Platform designed to represent latest clinical and genetic insights with more than 4,800 cytogenic relevant genes based on ClinGen, DDG2P, ClinVar, PharmGKB, NHGRI-EBI, and GWAS database
Delivering high-quality analysis via a wide range of samples including CentoCard®, EDTA blood, ready to use DNA, buccal swab, chronic villi, and amniotic fluid
| Features & Performance | |
|---|---|
| Characteristics | Genome-wide cytogenetic analysis to detect structural aberrations, such as CNVs, chromosomal imbalances, LOH, UPD, and mosaicism |
| Total markers (polymorphic) | 1.8 Million SNP markers |
| Resolution of CNVs detection | >50kb for copy number loss >200kb for copy number gain |
| Detection of AOH/LOH | >10 Mb |
| Mosaicism detection | Down to 30% |
| Exon level resolution for | ~4800 cytogenic relevant genes |
| Sample Types | CentoCard, EDTA-blood, ready to use DNA, buccal swab, amniotic fluid, chorionic villi, cord blood, and tissue and biopsy |
| TAT | 15 business days |
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