Scientific Publication 

Prodromal substantia nigra sonography undermines suggested association between substrate accumulation and the risk for GBA‐related Parkinson’s disease

Author(s): Rolfs, Prof. Arndt, MD, Brüggemann, Norbert, MD, Dinur, Tama, PhD, Zimran, Ari, MD, Cozma, Dr. rer. nat. Claudia, MD, Revel-Vilk, Shoshana, MD MSc, Becker Cohen, Michal, MSc, Arkadir, David, Dr., Tiomkin, Maayan

Parkinson’s disease (PD) and Gaucher disease are amongst the primary research foci at Centogene. As both conditions may be caused by mutations in the GBA gene, a common pathomechanism is widely assumed. Based on a combination of several approaches, an international team of GBA experts involving Centogene researchers now questioned this hypothesis. The findings, which strongly impact on therapeutic considerations for GBA-related PD, were recently published in the European Journal of Neurology


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