Author(s): Rolfs, Prof. Arndt, MD, Lukas, Jan, PhD, Bohl, Cornelius, Pomorski, Adam, PhD, Seemann, Susanne, Knospe, Anne-Marie, Zheng, Chaonan, Krężel, Artur, PhD
This study demonstrated fluorescent probes for selective protein labeling in lysosomes in a case of α-galactosidase A. Read more in this scientific publication!
This study demonstrated fluorescent probes for selective protein labeling in lysosomes in a case of α-galactosidase A, contributing further to the knowledge about diagnostics and pathology of Fabry disease. The newly investigated fluorescence-based live-cell-imaging technology of specifically tagged lysosomal protein using an improved biarsenical probe showed that it can be used to identify novel compounds that promote proper trafficking of mutant α-galactosidase to lysosomal compartments and rescue the mutant phenotype.
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