{"id":2380,"date":"2019-06-24T00:00:00","date_gmt":"2019-06-24T00:00:00","guid":{"rendered":"http:\/\/centogene.vl22350.dinaserver.com\/2380"},"modified":"2019-06-24T00:00:00","modified_gmt":"2019-06-24T00:00:00","slug":"%e4%b8%80%e9%a1%b9%e4%b8%ba%e6%9c%9f%e5%9b%9b%e5%b9%b4%e7%9a%84%e7%a0%94%e7%a9%b6%e6%8f%ad%e7%a4%ba%e4%ba%86%e6%ba%b6%e9%85%b6%e4%bd%93gb1%e5%9c%a8%e7%9b%91%e6%b5%8b%e6%88%88%e8%b0%a2%e7%97%85","status":"publish","type":"post","link":"https:\/\/www.centogene.com\/zh\/four-year-study-reveals-importance-of-lyso-gb1-in-monitoring-gaucher-disease-patients\/","title":{"rendered":"\u4e00\u9879\u4e3a\u671f\u56db\u5e74\u7684\u7814\u7a76\u63ed\u793a\u4e86\u6eb6\u9176\u4f53Gb1\u5728\u76d1\u6d4b\u6208\u8c22\u75c5\u60a3\u8005\u4e2d\u7684\u91cd\u8981\u6027"},"content":{"rendered":"<p>\u57282019\u5e746\u6708\u53d1\u8868\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c <em>\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7<\/em>, \u4e00\u9879\u9488\u5bf9 81 \u540d\u60a3\u6709\u4e0d\u540c\u4e25\u91cd\u7a0b\u5ea6\u6208\u8c22\u75c5 (GD) \u7684\u513f\u7ae5\u8fdb\u884c\u7684\u4e3a\u671f\u56db\u5e74\u7684\u7814\u7a76\u8868\u660e\uff0c\u8461\u8404\u7cd6\u9798\u6c28\u9187 (lyso-Gb1) \u662f\u4e00\u79cd\u975e\u5e38\u51c6\u786e\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u53ef\u7528\u4e8e\u76d1\u6d4b\u60a3\u6709 GD \u7684\u513f\u7ae5\u3002.<\/p>\n<p>\u8fd9\u9879\u7814\u7a76\u662f\u9996\u4e2a\u8bc4\u4f30\u6eb6\u8840\u78f7\u8102\u9170\u80c6\u78b1-1 (lyso-Gb1) \u5728\u76d1\u6d4b\u5df2\u6cbb\u7597\u548c\u672a\u6cbb\u7597\u513f\u7ae5\u4e2d\u7684\u4f5c\u7528\u7684\u7814\u7a76\uff0c\u5b83\u63ed\u793a\u4e86 lyso-Gb1 \u5728\u513f\u7ae5\u6cbb\u7597\u76d1\u6d4b\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u8be5\u7814\u7a76\u59cb\u4e8e 2014 \u5e74\uff0c\u5229\u7528 CENTOGENE \u516c\u53f8\u5f00\u53d1\u7684\u4e13\u6709\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5bf9\u4ee5\u8272\u5217\u8036\u8def\u6492\u51b7\u6c99\u96f7\u00b7\u6cfd\u5fb7\u514b\u533b\u7597\u4e2d\u5fc3 (Shaare Zedek Medical Center) \u6536\u6cbb\u7684\u513f\u7ae5\u7684 lyso-Gb1 \u6c34\u5e73\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002\u6b64\u524d\u5173\u4e8e lyso-Gb1 \u4f5c\u4e3a\u751f\u7269\u6807\u5fd7\u7269\u7684\u7814\u7a76\u4ec5\u9650\u4e8e\u6210\u4eba\u6208\u8c22\u75c5 (GD) \u60a3\u8005\u3002.<\/p>\n<p>\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff1a<\/p>\n<p>\u4e24\u8005\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u76f8\u5173\u6027\uff1a<\/p>\n<ul>\n<li>\u8f7b\u5ea6GD1\u60a3\u513f\u7684\u6eb6\u8840\u78f7\u8102\u9170\u80c6\u78b1-1 (lyso-Gb1) \u548c\u8840\u5c0f\u677f\u8ba1\u6570<\/li>\n<li>\u91cd\u5ea6GD1\u60a3\u513f\u7684\u6eb6\u8840\u78f7\u8102\u9170\u80c6\u78b1-1 (lyso-Gb1) \u548c\u8840\u7ea2\u86cb\u767d\u6c34\u5e73<\/li>\n<\/ul>\n<p>\u4e24\u8005\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u8d1f\u76f8\u5173\u5173\u7cfb\uff1a<\/p>\n<ul>\n<li>\u672a\u7ecf\u6cbb\u7597\u513f\u7ae5\u7684\u6eb6\u8840\u7d20-Gb1 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Rolfs\u6559\u6388\u8bc4\u8bba\u9053\u3002\u201c\u751f\u7269\u6807\u5fd7\u7269\u5728\u7f55\u89c1\u75c5\u60a3\u8005\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u76d1\u6d4b\u4e2d\u81f3\u5173\u91cd\u8981\uff0c\u5c24\u5176\u5bf9\u4e8e\u60a3\u6709\u6208\u8c22\u75c5\u7684\u513f\u7ae5\uff0c\u6211\u4eec\u53d1\u73b0\u6eb6\u9176\u4f53Gb1\u662f\u4e00\u79cd\u6781\u5176\u6709\u6548\u7684\u6cbb\u7597\u76d1\u6d4b\u751f\u7269\u6807\u5fd7\u7269\u2014\u2014\u7684\u786e\u5e94\u8be5\u5c06\u5176\u7eb3\u5165\u8fd9\u4e9b\u60a3\u8005\u7684\u5e38\u89c4\u968f\u8bbf\u4e2d\u3002\u201d<\/p>\n<p>\u201c\u672a\u7ecf\u6cbb\u7597\u7684\u6208\u8c22\u75c5\u60a3\u513f\u4f53\u5185\u6eb6\u9176\u4f53Gb1\u6c34\u5e73\u7684\u9010\u6e10\u5347\u9ad8\u8868\u660e\uff0c\u8fd9\u4e9b\u60a3\u8005\u5e94\u8be5\u63a5\u53d7\u9176\u66ff\u4ee3\u7597\u6cd5\uff0c\u201d\u8036\u8def\u6492\u51b7\u5e0c\u4f2f\u6765\u5927\u5b66\u6c99\u96f7\u00b7\u6cfd\u5fb7\u514b\u533b\u5b66\u4e2d\u5fc3\u7684\u963f\u91cc\u00b7\u9f50\u59c6\u5170\u533b\u5b66\u535a\u58eb\u8865\u5145\u9053\u3002\u9f50\u59c6\u5170\u535a\u58eb\u662f\u6208\u8c22\u75c5\u9886\u57df\u7684\u77e5\u540d\u4e13\u5bb6\uff0c\u4e5f\u662f\u8fd9\u9879\u7814\u7a76\u7684\u4f5c\u8005\u4e4b\u4e00\u3002\u201c\u8fd9\u9879\u56fd\u9645\u7814\u7a76\u8868\u660e\uff0c\u6eb6\u9176\u4f53Gb1\u6c34\u5e73\u4e0e\u6208\u8c22\u75c5\u60a3\u513f\u7684\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u4e4b\u95f4\u5b58\u5728\u76f8\u5173\u6027\uff0c\u5e76\u5f3a\u8c03\u4e86\u4f7f\u7528\u8fd9\u79cd\u751f\u7269\u6807\u5fd7\u7269\u76d1\u6d4b\u5df2\u6cbb\u7597\u548c\u672a\u6cbb\u7597\u60a3\u513f\u7684\u91cd\u8981\u6027\u3002\u201d<\/p>\n<p>\u6208\u8c22\u75c5\u662f\u6700\u5e38\u89c1\u7684\u9690\u6027\u9057\u4f20\u6eb6\u9176\u4f53\u8d2e\u79ef\u75c7\u4e4b\u4e00\uff0c\u7531\u8461\u8404\u7cd6\u8111\u82f7\u8102\u9176\u7f3a\u4e4f\u5f15\u8d77\u3002.<\/p>\n<p>\u5168\u6587\u53ef\u4f9b\u4e0b\u8f7d <a href=\"https:\/\/www.mdpi.com\/1422-0067\/20\/12\/3033\" target=\"_blank\" title=\"\u4e0b\u8f7d\u8bba\u6587\">\u8fd9\u91cc<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>In a paper published in June 2019 in the International Journal of Molecular Sciences, a four-year study of 81 children [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2380","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Four Year Study Reveals Importance of Lyso-Gb1 in Monitoring Gaucher Disease Patients | CENTOGENE<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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