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  1. Understanding Neurodegeneration in Niemann-Pick Disease

Understanding Neurodegeneration in Niemann-Pick Disease

Michael Rabenstein 1 Nico Murr 1 Andreas Hermann, MD 1 Prof. Arndt Rolfs, MD 2 Moritz J Frech, PhD 1
1 University of Rostock 2 CENTOGENE AG
December 13, 2019

Alteration of GABAergic input precedes neurodegeneration of cerebellar Purkinje cells of NPC1-deficient mice

Niemann-Pick (NP) disease is a lysosomal storage disorder that involves the degeneration of certain neurons. A recent study, co-authored by CENTOGENE’s CEO Prof. Arndt Rolfs, investigated this process using an electrophysiological approach. The findings of disturbed synaptic signaling open up novel therapeutic options; they were published in the International Journal of Molecular Sciences.