1. Understanding DNA Alterations in Colorectal Cancer

Understanding DNA Alterations in Colorectal Cancer

Maja Hühns 1 Sylvia Nürnberg 2 Krishna Kumar Kandaswamy, PhD 2 Claudia Maletzki 3 Dr. Peter Bauer, MD 2 Friedrich Prall 1
1 University Medicine of Rostock 2 CENTOGENE AG 3 University of Rostock
December 19, 2019

High mutational burden in colorectal carcinomas with monoallelic POLE mutations: absence of allelic loss and gene promoter methylation

Germline and somatic DNA alterations may cause inherited diseases and/or cancer. While CENTOGENE’s routine diagnostic focus is on the former, we frequently address oncological questions in research settings. Deep sequencing of colorectal tumors in one such project provided unprecedented insights into the evolution of this type of cancer. The findings were recently published in Modern Pathology.