1. Articles on oncogenetics

Oncogenetics

Diagnose hereditary cancer before symptoms appear - early treatment could be life-saving. Genetic testing for cancer-associated gene changes offers the possibility to find the best, specific treatment option for a patient, and to predict disease risk for both the patient and family members.

Articles on oncogenetics

  • Bone marrow failure

    Bone Marrow Failure is a clinically and genetically heterogeneous collection of diseases affecting hematopoiesis, resulting in reduced or abnormal production of one or more of the three blood cell types (red blood cell, white blood cell and platelets). Symptoms and onset vary greatly depending on…

  • Myeloid tumor panel

    Myeloid malignancies are clonal diseases of hematopoietic progenitor cells (cells that are capable of multiplying and producing additional blood cells of a particular lineage) resulting from genetic and epigenetic alterations that disrupt proliferation, differentiation and self-renewal of…

  • PGL/PCC/GIST gene panel

    Paragangliomas (PGL) are tumors that arise from neuroendocrine tissues along the vertebrae. They can hypersecrete catecholamines or be non-secretory. Pheochromocytomas (PCC) are PGL tumors confined to the adrenal glands and usually secrete catecholamines. Gastrointestinal stromal tumors (GIST) are…

  • Neurofibromatosis panel

    Neurofibromatoses (NF) are a group of disorders characterized by the development of tumors in the nervous system. These benign tumors develop on the nerve sheath and are known as neurofibromas. Other findings include skin and bone abnormalities. The severity of the disease varies considerably even…

  • Ovarian cancer

    Ovarian cancer is the most lethal of all gynecological cancers, and the annual incidence of ovarian cancer is 12.1 per 100,000 women. Familial ovarian carcinoma has been described in the context of hereditary breast and ovarian cancer (HBOC) syndrome. Inherited in an autosomal dominant fashion, HBOC…