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CentoWebinar – Hereditary Angioedema (HAE): Hidden in Plain Sight

Watch our webinar, where Dr. Aida M. Bertoli-Avella, Head of Research Data Analysis, Dr. Volha Skrahina, Vice Director Clinical Studies, and Dr. Selen Zülbahar, Clinical Project Manager & Team Leader (EHA Project Lead) discuss about Hereditary Angioedema.Throughout the webinar, they will provide an overview of this rare genetic disorder and discuss the latest biochemical and genetic diagnostic methods. Additionally, they will introduce our current HAE-related clinical studies.

Key Topics:

  • HAE Facts: Who? When? Where? What?
  • HAE Physiopathology: Contact, Complement, and Plasminogen Activation Systems
  • HAE Biomarkers: cHMWK, Factor XII, Pre-KK/KK, BK
  • HAE Studies at CENTOGENE: Rationale, Design, Objectives, Eligibility Criteria

Our speakers

Dr. Aida M. Bertoli-Avella, Head of Research Data Analysis

Dr. Aida M. Bertoli-Avella, graduated from the Institute of Medical Sciences, Santiago de Cuba. In 2004, she obtained her PhD in Human Genetics at the Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands...

...She received several grants and was a recipient of the prestigious Erasmus Fellowship in 2009. Major research accomplishments include the discovery of mutations in several genes causing congenital cardiovascular diseases, which led to new diagnostic tests, improved patient care guidelines, and major scientific publications. After 18 years of experience in academia, she joined CENTOGENE GmbH in Germany, where she now serves as Head of Research Data Analysis.

Dr. Volha Skrahina, Vice Director Clinical Studies

In her role as Vice Director Clinical Studies, Dr. Volha Skrahina, leads CENTOGENE’s worldwide epidemiological, observational non-interventional clinical studies. The studies aim to screen at-risk populations for rare hereditary diseases – providing newly-diagnosed patients knowledge on treatment and investigational drug trial opportunities...

...In addition, Volha manages biomarker clinical studies to identify new molecules for rapid cost-effective disease testing, treatment monitoring, and personalization.

Volha and her team organize charity projects in developing countries all over the world. These projects lead to patient diagnostic opportunities as well as the discovery of previously unknown diseases.

Volha started her career in rare diseases with the investigation of genetics of Sudden Death Syndrome during her bachelor’s thesis at the Republican Theoretical and Practical Center – ‘Mother and Child’ in Minsk, Belarus. Afterwards, she analyzed the microbial translation system influence on host immune responses during her master’s thesis at the Max Plank Institute in Berlin, Germany. Her successful PhD thesis on the host fungal micronutrient interaction was completed at the Hans Knoell Institute in Jena, Germany in 2018.

Dr. Selen Zülbahar, Clinical Project Manager & Team Leader (EHA Project Lead)

Dr. Selen Zülbahar, serves as a Clinical Studies Team Leader at CENTOGENE, where she is responsible for three Hereditary Angioedema (HAE) disease-related clinical study programs. Selen received her bachelor’s and master’s degree in Molecular Biology and Genetics in Turkey...

...Later on she moved to Münster, Germany where she was awarded a scholorship from the Cells in Motion - International Max Planck Research School (CiM-IMPRS) graduate program. After successful completion of her doctoral studies, she moved to the clinical research field. Following her first work experience at a contract research organization, Selen joined CENTOGENE in April 2019 to actively contribute to worldwide, multicentre, non-interventional studies.