{"id":899,"date":"2025-02-27T15:32:22","date_gmt":"2025-02-27T15:32:22","guid":{"rendered":"http:\/\/centogene.vl22350.dinaserver.com\/?page_id=899"},"modified":"2025-04-07T11:30:00","modified_gmt":"2025-04-07T11:30:00","slug":"analise-epidemiologica-para-doenca-de-angioedema-hereditario-estudo-eha","status":"publish","type":"page","link":"https:\/\/www.centogene.com\/pt\/pharma\/clinical-trial-support\/epidemiological-analysis-for-hereditary-angioedema-disease-eha-study\/","title":{"rendered":"Estudo EHA"},"content":{"rendered":"<section class=\"bloque-banner-titulo-page  estilo-grey\" id=\"\">\r\n    \r\n    <div class=\"image-wrapper\">\r\n\r\n      <!-- include mp4 video on a loop -->\r\n              <img decoding=\"async\" class=\"\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/csm_centogene-pharma-clinical-trails_EHA-header_55006e3c19.webp\" alt=\"csm_centogene-pharma-clinical-trails_EHA-header_55006e3c19\" \/>\r\n          <\/div>\r\n    <div class=\"container content-wrapper\">\r\n      <div class=\"row justify-content-start align-items-center\">\r\n\r\n\r\n        <div class=\"col-12 col-lg-6 animation fadeTop align-self-center\">\r\n                  <h1>Estudo EHA<\/h1>\r\n          <h2 class=\"bl-texto\">An\u00e1lise epidemiol\u00f3gica da doen\u00e7a de angioedema heredit\u00e1rio<\/h2>                            <\/div>\r\n\r\n      <\/div>\r\n    <\/div>\r\n\r\n<\/section>\r\n<div class=\"breadcrumbs\">\r\n    <div class=\"container\">\r\n      <div class=\"row\">\r\n        <div class=\"col-12\">\r\n          <ul id=\"breadcrumbs\" class=\"breadcrumbs\"><li><a href=\"https:\/\/www.centogene.com\/pt\/\">Home<\/a><\/li><\/ul>        <\/div>\r\n      <\/div>\r\n    <\/div>\r\n<\/div>\r\n\r\n\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente-my\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Resumo<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Vis\u00e3o geral<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">A An\u00e1lise Epidemiol\u00f3gica do Angioedema Heredit\u00e1rio (AEH) \u00e9 um estudo observacional internacional. O principal objetivo do estudo \u00e9 investigar a preval\u00eancia de Angioedema Heredit\u00e1rio (AEH) entre participantes com epis\u00f3dios recorrentes de dor abdominal sem etiologia aparente. Al\u00e9m disso, o estudo visa identificar biomarcadores de AEH que possam facilitar o diagn\u00f3stico precoce e a personaliza\u00e7\u00e3o do tratamento no futuro.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Benef\u00edcios para participantes<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Os participantes podem receber um diagn\u00f3stico definitivo de AEH tipo 1\/2. Isso tamb\u00e9m pode ter um impacto direto na fam\u00edlia dos indiv\u00edduos diagnosticados devido \u00e0 natureza heredit\u00e1ria dominante da doen\u00e7a.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">    <section class=\"bloque-personalizado bloque-cajas-imgs estilo-cajasblancas\" >\n        <div class=\"\"> \n                        <div class=\"row justify-content-between\">\n\n                                        \n                <div class=\"swiper-slide col-12 delay-1 caja\">\n                    <div class=\"caja-inner\" >\n                        <a href=\"https:\/\/www.centoportal.com\/\" target=\"_blank\" class=\"\">                        <div class=\"bl-imagen animationNo scalexTop delay-1\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/csm_centogene-pharma-clinical-trials_study-access-teaser-card_7fbd33e2a0-650x400.webp\" class=\"\" alt=\"\" \/> <\/div>                                               \n                        <\/a>                        \n                        <div class=\"caja-text\">\n                            <p class=\"prefijo\">Ensaios cl\u00ednicos<\/p>                            <h3 class=\"bl-titulo\">Acesso ao estudo no CentoPortal\u00ae para m\u00e9dicos participantes.<\/h3>\n                                  \n                                                          <a target=\"_blank\" href=\"https:\/\/www.centoportal.com\/\" class=\"btn btn-primary\">CentoPortal\u00ae<\/a>\n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                                     \n             \n            \n        <\/div>\n    <\/div>  \n<\/section>\n\n\n\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocolor\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h2 class=\"wp-block-heading\">Justificativa e delineamento do estudo<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Justificativa do estudo<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">A angioedema heredit\u00e1ria (AEH) \u00e9 uma doen\u00e7a heredit\u00e1ria autoss\u00f4mica dominante que frequentemente \u00e9 subdiagnosticada ou diagnosticada erroneamente. Crises recorrentes de dor abdominal, que \u00e0s vezes s\u00e3o a \u00fanica manifesta\u00e7\u00e3o da doen\u00e7a, podem ser confundidas com outras condi\u00e7\u00f5es, como transtornos psiqui\u00e1tricos ou apendicite, resultando em procedimentos m\u00e9dicos e cir\u00fargicos desnecess\u00e1rios.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A doen\u00e7a geralmente n\u00e3o \u00e9 diagnosticada at\u00e9 o final da adolesc\u00eancia, e indiv\u00edduos n\u00e3o diagnosticados podem apresentar epis\u00f3dios frequentes de dor abdominal que podem prejudicar sua qualidade de vida. O estudo EHA ajudar\u00e1 no diagn\u00f3stico precoce desses indiv\u00edduos e, assim, atualizar\u00e1 a preval\u00eancia de AHE. Al\u00e9m disso, as an\u00e1lises bioqu\u00edmicas realizadas em amostras positivas para AHE dar\u00e3o suporte ao desenvolvimento de novas ferramentas diagn\u00f3sticas para a doen\u00e7a.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Desenho do estudo<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Os participantes que preencherem os crit\u00e9rios de elegibilidade poder\u00e3o ser inscritos no estudo. Ser\u00e1 coletada uma \u00fanica amostra de sangue (cerca de 1 ml) de todos os participantes. Essa amostra ser\u00e1 aplicada em um...&nbsp;<a href=\"https:\/\/www.centogene.com\/pt\/inovacao\/centocard\/\" data-type=\"page\" data-id=\"1453\">CentoCard<sup>\u00ae<\/sup><\/a>, que ser\u00e1 enviado \u00e0 CENTOGENE e analisado nos laborat\u00f3rios especializados em AEH da CENTOGENE. O fluxo de trabalho diagn\u00f3stico consiste em duas etapas: na primeira, as prote\u00ednas do complemento s\u00e3o quantificadas por espectrometria de massa em tandem e, na segunda, os resultados s\u00e3o confirmados por an\u00e1lises gen\u00e9ticas. Os resultados bioqu\u00edmicos s\u00e3o, portanto, confirmados geneticamente por meio do sequenciamento de nova gera\u00e7\u00e3o (NGS) do&nbsp;<em>SERPING1<\/em>&nbsp;gene, e quando necess\u00e1rio, a Amplifica\u00e7\u00e3o de Sondas Dependente de Liga\u00e7\u00e3o Multiplex (MLPA) \u00e9 realizada para identificar grandes dele\u00e7\u00f5es ou duplica\u00e7\u00f5es.<br><br>A CENTOGENE entrar\u00e1 em contato com o m\u00e9dico respons\u00e1vel pelo estudo para inform\u00e1-lo sobre os resultados dos testes. Somente os participantes diagnosticados com AEH ser\u00e3o informados pelo m\u00e9dico respons\u00e1vel pelo estudo. Caso o participante n\u00e3o seja contatado pelo centro de pesquisa dentro de um m\u00eas, os resultados poder\u00e3o ser considerados negativos.<\/p>\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente-my\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Informa\u00e7\u00f5es sobre o estudo<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Projeto:<\/strong>&nbsp;Estudo observacional epidemiol\u00f3gico multic\u00eantrico internacional<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Popula\u00e7\u00e3o do estudo:<\/strong>&nbsp;Indiv\u00edduos com epis\u00f3dios anteriores de crises de dor abdominal sem etiologia \u00f3bvia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>N\u00famero de participantes:&nbsp;<\/strong>5.000 participantes<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Primeiro participante em:<\/strong>&nbsp;Setembro de 2018<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u00daltimo participante em:&nbsp;<\/strong>Junho de 2022<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Per\u00edodo de inclus\u00e3o:<\/strong>&nbsp;48 meses<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Objetivos:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Prim\u00e1rio<\/strong>&nbsp;\u2013 Investigar a preval\u00eancia de AHA em indiv\u00edduos com epis\u00f3dios pr\u00e9vios de dor abdominal sem etiologia \u00f3bvia.<br><strong>Secund\u00e1rio<\/strong>&nbsp;\u2013 Estabelecer um biomarcador na coorte HAE-positiva<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br>Descubra como voc\u00ea pode participar:&nbsp;<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03558009?recrs=a&amp;type=Obsr&amp;cond=HAE&amp;rank=5\" target=\"_blank\" rel=\"noreferrer noopener\">ClinicalTrials.gov&nbsp;<\/a>&nbsp;|&nbsp;&nbsp;<strong>O processo de recrutamento est\u00e1 encerrado.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Crit\u00e9rios de inclus\u00e3o<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Crit\u00e9rios de inclus\u00e3o<\/th><\/tr><\/thead><tbody><tr><td>O consentimento informado \u00e9 obtido do participante ou do pai\/m\u00e3e\/respons\u00e1vel legal.<\/td><\/tr><tr><td>O participante j\u00e1 apresentou epis\u00f3dios anteriores de dor abdominal sem causa aparente.<\/td><\/tr><tr><td>Participantes com idades entre 2 e 60 anos.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u00c2mbito Geogr\u00e1fico<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full imgshadow\"><img loading=\"lazy\" decoding=\"async\" width=\"1293\" height=\"701\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/centogene_clinical_studies_global_patient_studies_200506-EHA-study-map.webp\" alt=\"\" class=\"wp-image-897\" srcset=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/centogene_clinical_studies_global_patient_studies_200506-EHA-study-map.webp 1293w, https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/centogene_clinical_studies_global_patient_studies_200506-EHA-study-map-1024x555.webp 1024w, https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/centogene_clinical_studies_global_patient_studies_200506-EHA-study-map-768x416.webp 768w\" sizes=\"auto, (max-width: 1293px) 100vw, 1293px\" \/><\/figure>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">Vis\u00e3o geral dos pa\u00edses que participam do estudo EHA. Os pontos indicam a sede da CENTOGENE GmbH (Rostock, Alemanha). (\u00a9 Colaboradores do OpenStreetMap)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O estudo EHA est\u00e1 sendo conduzido no M\u00e9xico, Alemanha, It\u00e1lia, Turquia, Pol\u00f4nia e Jap\u00e3o.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Informa\u00e7\u00f5es sobre a doen\u00e7a HAE<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Uma doen\u00e7a heredit\u00e1ria caracterizada por angioedema mediado por bradicinina.<\/li>\n\n\n\n<li class=\"translation-block\">Uma doen\u00e7a autoss\u00f4mica dominante causada principalmente por muta\u00e7\u00f5es no gene <em>SERPING1<\/em> , que codifica a prote\u00edna inibidora da C1 esterase plasm\u00e1tica (C1-INH).<\/li>\n\n\n\n<li>A preval\u00eancia relatada varia de 1:10.000 a 1:50.000.<\/li>\n\n\n\n<li>A variante 93% dos pacientes com HAE sofre de dor abdominal recorrente devido a edemas gastrointestinais, que pode ser a \u00fanica manifesta\u00e7\u00e3o da doen\u00e7a.<\/li>\n\n\n\n<li>Indiv\u00edduos com sintomas gastrointestinais raramente s\u00e3o suspeitos de ter AHE (Aumento Angiotensino-Hematopoi\u00e9tico) e podem enfrentar diagn\u00f3sticos err\u00f4neos por uma m\u00e9dia de oito anos.<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n  <section class=\"bloque-personalizado bloque-contact-info\" >     \n    <h2 class=\"mt-3 mb-5\"> Entre em contato com o estudo EHA<\/h2>   \n    <div class=\"row justify-content-center bordesverticales\"> \n        <div class=\"bl-texto col-12 col-md-3\">\n         <h5 class=\"mt-0\">Para obter mais informa\u00e7\u00f5es, entre em contato.<\/h5>\n<p><strong>Dra. Anika Knaust, pesquisadora de estudos cl\u00ednicos<\/strong><br \/>\nCENTOGENE GmbH<br \/>\nNa Praia 7<br \/>\n18055 Rostock<br \/>\nAlemanha<br \/>\nE-mail: Anika.Knaust@centogene.com<\/p>\n<hr \/>\n<p><strong>Limor Oren, Assistente de Pesquisa Cl\u00ednica<\/strong><br \/>\nCENTOGENE GmbH<br \/>\nNa Praia 7<br \/>\n18055 Rostock<br \/>\nAlemanha<br \/>\nE-mail: limor.oren@centogene.com<\/p>\n        <\/div>\n        <div class=\"bl-texto  col-12 col-md-2\">\n          \n        <\/div>\n        <div class=\"bl-texto  col-12 col-md-3\">\n          <h5 class=\"mt-0\">Ensaios cl\u00ednicos<\/h5>\n<h4 class=\"translation-block\">Acesso ao estudo no <sup>CentoPortal\u00ae<\/sup> para m\u00e9dicos participantes.<\/h4>\n<p><a class=\"btn btn-primary\" title=\"CentoPortal\" href=\"https:\/\/login.centoportal.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">CentoPortal<\/a><\/p>\n        <\/div>\n    <\/div>\n  <\/section>  \n\n  \n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":1078,"menu_order":50,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-899","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>EHA Study | CENTOGENE<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.centogene.com\/pt\/farmaceutica\/apoio-a-ensaios-clinicos\/analise-epidemiologica-para-doenca-de-angioedema-hereditario-estudo-eha\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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