{"id":824,"date":"2025-02-27T10:21:55","date_gmt":"2025-02-27T10:21:55","guid":{"rendered":"http:\/\/centogene.vl22350.dinaserver.com\/?page_id=824"},"modified":"2025-04-03T17:18:51","modified_gmt":"2025-04-03T17:18:51","slug":"imunizacao-baseada-em-peptideos-para-carcinoma-de-colon-e-pancreas-picop-global","status":"publish","type":"page","link":"https:\/\/www.centogene.com\/pt\/pharma\/clinical-trial-support\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\/","title":{"rendered":"PiCoP-GLOBAL"},"content":{"rendered":"<section class=\"bloque-banner-titulo-page  estilo-grey\" id=\"\">\r\n    \r\n    <div class=\"image-wrapper\">\r\n\r\n      <!-- include mp4 video on a loop -->\r\n              <img decoding=\"async\" class=\"\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/csm_centogene-pharma-clinical-trails_PiCoP-global-header_f7e9060779.webp\" alt=\"csm_centogene-pharma-clinical-trails_PiCoP-global-header_f7e9060779\" \/>\r\n          <\/div>\r\n    <div class=\"container content-wrapper\">\r\n      <div class=\"row justify-content-start align-items-center\">\r\n\r\n\r\n        <div class=\"col-12 col-lg-6 animation fadeTop align-self-center\">\r\n                  <h1>PiCoP-GLOBAL<\/h1>\r\n          <h2 class=\"bl-texto\">Imuniza\u00e7\u00e3o baseada em pept\u00eddeos para carcinoma de c\u00f3lon e p\u00e2ncreas<\/h2>                            <\/div>\r\n\r\n      <\/div>\r\n    <\/div>\r\n\r\n<\/section>\r\n<div class=\"breadcrumbs\">\r\n    <div class=\"container\">\r\n      <div class=\"row\">\r\n        <div class=\"col-12\">\r\n          <ul id=\"breadcrumbs\" class=\"breadcrumbs\"><li><a href=\"https:\/\/www.centogene.com\/pt\/\">Home<\/a><\/li><\/ul>        <\/div>\r\n      <\/div>\r\n    <\/div>\r\n<\/div>\r\n\r\n\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente-my\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Resumo<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Vis\u00e3o geral<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">O PiCoP-GLOBAL \u00e9 um estudo observacional epidemiol\u00f3gico multic\u00eantrico internacional com o objetivo de desenvolver ferramentas de diagn\u00f3stico para terapias personalizadas baseadas na imunidade em tumores de c\u00f3lon e p\u00e2ncreas. Este estudo est\u00e1 intimamente ligado ao estudo nacional PiCoP na Alemanha e a um estudo de vacina\u00e7\u00e3o subsequente.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O estudo PiCoP-GLOBAL (Peptide-based Immunization for Colon- and Pancreas-Carcinoma Study) \u00e9 um estudo observacional global que se concentra na identifica\u00e7\u00e3o de neoant\u00edgenos espec\u00edficos de tumores como base para o desenvolvimento de uma terapia personalizada, baseada na imunidade, que visa a resposta imune do pr\u00f3prio paciente contra o tumor.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">    <section class=\"bloque-personalizado bloque-cajas-imgs estilo-cajasblancas\" >\n        <div class=\"\"> \n                        <div class=\"row justify-content-between\">\n\n                                        \n                <div class=\"swiper-slide col-12 delay-1 caja\">\n                    <div class=\"caja-inner\" >\n                        <a href=\"https:\/\/www.centoportal.com\/\" target=\"_blank\" class=\"\">                        <div class=\"bl-imagen animationNo scalexTop delay-1\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/csm_centogene-pharma-clinical-trials_study-access-teaser-card_7fbd33e2a0-650x400.webp\" class=\"\" alt=\"\" \/> <\/div>                                               \n                        <\/a>                        \n                        <div class=\"caja-text\">\n                            <p class=\"prefijo\">Ensaios cl\u00ednicos<\/p>                            <h3 class=\"bl-titulo\">Acesso ao estudo no CentoPortal\u00ae para m\u00e9dicos participantes.<\/h3>\n                                  \n                                                          <a target=\"_blank\" href=\"https:\/\/www.centoportal.com\/\" class=\"btn btn-primary\">CentoPortal\u00ae<\/a>\n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                                     \n             \n            \n        <\/div>\n    <\/div>  \n<\/section>\n\n\n\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocolor\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h2 class=\"wp-block-heading\">Justificativa e delineamento do estudo<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Justificativa do estudo<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">O tratamento padr\u00e3o para c\u00e2ncer de c\u00f3lon e p\u00e2ncreas depende do est\u00e1gio da doen\u00e7a e inclui cirurgia, quimioterapia e radioterapia. No entanto, como o progn\u00f3stico de tumores avan\u00e7ados de c\u00f3lon e p\u00e2ncreas, em geral, \u00e9 muito ruim, h\u00e1 uma necessidade urgente de tratamentos melhores.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O aprimoramento da resposta imune por meio da vacina\u00e7\u00e3o est\u00e1 entre as novas op\u00e7\u00f5es terap\u00eauticas, utilizando ant\u00edgenos espec\u00edficos de c\u00e9lulas, ant\u00edgenos tumorais superexpressos ou ant\u00edgenos tumorais mutados (neoep\u00edtopos). O maior potencial para alta especificidade, embora pressuponha uma caracteriza\u00e7\u00e3o extensa do tumor em quest\u00e3o, reside nos ant\u00edgenos tumorais mutados. Para identificar uma abordagem de vacina\u00e7\u00e3o baseada em neoep\u00edtopos para op\u00e7\u00f5es de tratamento individualizadas para cada paciente, as caracter\u00edsticas moleculares dos tumores devem ser analisadas primeiramente.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Os participantes do estudo ter\u00e3o acesso a relat\u00f3rios m\u00e9dicos com muta\u00e7\u00f5es som\u00e1ticas relacionadas ao diagn\u00f3stico de c\u00e2ncer por meio de seus m\u00e9dicos.<\/li>\n\n\n\n<li>Caso sejam encontrados neoant\u00edgenos adequados para a produ\u00e7\u00e3o de vacinas individualizadas para cada paciente, a inclus\u00e3o no estudo cl\u00ednico de acompanhamento torna-se poss\u00edvel.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Todos os pacientes que participam do PiCoP-GLOBAL dar\u00e3o uma importante contribui\u00e7\u00e3o para a compreens\u00e3o dos tumores de c\u00f3lon e p\u00e2ncreas e para o potencial desenvolvimento de op\u00e7\u00f5es de tratamento individualizadas.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Desenho do estudo<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Os participantes que preencherem os crit\u00e9rios de inclus\u00e3o ser\u00e3o inscritos no estudo ap\u00f3s fornecerem o consentimento informado. No momento da cirurgia padr\u00e3o para remo\u00e7\u00e3o do tumor, ser\u00e1 coletada uma amostra de sangue para pesquisa de todos os participantes. Do tecido removido durante o tratamento cir\u00fargico, ser\u00e3o obtidas uma amostra tumoral e uma amostra de tecido controle para o estudo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Amostras de sangue adicionais podem ser coletadas em momentos diferentes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Todos os materiais s\u00e3o enviados para a CENTOGENE e analisados no laborat\u00f3rio da CENTOGENE na Alemanha.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As amostras ser\u00e3o testadas geneticamente para muta\u00e7\u00f5es associadas a tumores e por espectrometria de massa em tandem (MS\/MS) para neoep\u00edtopos e estudos de biomarcadores. Os dados coletados ser\u00e3o usados em uma abordagem multi\u00f4mica para prever neoep\u00edtopos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Amostras de sangue de acompanhamento ser\u00e3o testadas geneticamente e por meio de monitoramento imunol\u00f3gico espec\u00edfico para verificar uma resposta imune preexistente contra neoant\u00edgenos em pacientes n\u00e3o vacinados, para monitorar a resposta imune dos pacientes durante a quimioterapia e para monitorar a resposta dos pacientes ao tratamento.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Qualquer paciente em que sejam encontrados neoant\u00edgenos promissores para a produ\u00e7\u00e3o de vacinas poder\u00e1 ser convidado a participar de um futuro estudo cl\u00ednico.<\/p>\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente-my\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Informa\u00e7\u00f5es sobre o estudo<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Projeto:<\/strong>&nbsp;Estudo epidemiol\u00f3gico observacional n\u00e3o intervencionista internacional<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Popula\u00e7\u00e3o do estudo:<\/strong>&nbsp;Pacientes com carcinoma pancre\u00e1tico ou colorretal submetidos \u00e0 cirurgia<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>N\u00famero de pacientes:&nbsp;<\/strong>100 participantes<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Primeiro paciente a entrar:<\/strong>&nbsp;Abril de 2019<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u00daltimo paciente a entrar:&nbsp;<\/strong>Junho de 2021<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Per\u00edodo de inclus\u00e3o:<\/strong>&nbsp;24 meses<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Objetivos:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Identifica\u00e7\u00e3o de muta\u00e7\u00f5es espec\u00edficas do tumor em n\u00edvel gen\u00f4mico.<\/li>\n\n\n\n<li>Valida\u00e7\u00e3o de muta\u00e7\u00f5es espec\u00edficas de tumores em n\u00edvel transcricional e\/ou translacional.<\/li>\n\n\n\n<li>Desenvolvimento de uma estrat\u00e9gia de vacina\u00e7\u00e3o personalizada.<\/li>\n\n\n\n<li>Desenvolvimento de estrat\u00e9gias de diagn\u00f3stico de acompanhamento.<\/li>\n\n\n\n<li>Estabelecimento de biomarcadores em pacientes com carcinoma de p\u00e2ncreas ou de c\u00f3lon.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Mirar:<\/strong>&nbsp;Desenvolvimento de op\u00e7\u00f5es de tratamento individualizadas para tumores de c\u00f3lon e p\u00e2ncreas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Descubra como voc\u00ea pode participar:&nbsp;<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03871790?term=picop&amp;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">ClinicalTrials.gov<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Crit\u00e9rios de inclus\u00e3o<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Crit\u00e9rios de inclus\u00e3o<\/th><\/tr><\/thead><tbody><tr><td>O consentimento informado \u00e9 obtido do participante.<\/td><\/tr><tr><td>Pacientes com carcinoma pancre\u00e1tico ou colorretal submetidos \u00e0 cirurgia<\/td><\/tr><tr><td>O participante tem mais de 18 anos de idade.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Parceiros de Coopera\u00e7\u00e3o<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A CENTOGENE est\u00e1 colaborando nesse projeto com empresas de biotecnologia, a Universidade de Rostock e a Universidade de Greifswald no estudo PiCoP, viabilizado por meio de cofinanciamento do Fundo Europeu de Desenvolvimento Regional (FEDER). Al\u00e9m do recrutamento de pacientes, ambas as universidades contribuem com projetos cient\u00edficos para estudos da via PI3K\/ATK\/mTOR, estabelecimento de linhagens celulares ou modelos de transplante, monitoramento imunol\u00f3gico e perfil epigen\u00e9tico em tecido de c\u00e2ncer de c\u00f3lon.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">A CENTOGENE tamb\u00e9m est\u00e1 colaborando com parceiros internacionais no estudo global PiCoP, com o primeiro centro internacional inclu\u00eddo no estudo em abril de 2019, em parceria com organiza\u00e7\u00f5es no Paquist\u00e3o (todos membros da <a href=\"http:\/\/www.sospk.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sociedade de Oncologia Cir\u00fargica do Paquist\u00e3o<\/a> ).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Fatos sobre doen\u00e7as<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Informa\u00e7\u00f5es sobre o carcinoma colorretal*<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>O c\u00e2ncer colorretal \u00e9 a quarta causa mais comum de morte por c\u00e2ncer no mundo: estima-se que ocorram 694.000 mortes anualmente.<\/li>\n\n\n\n<li>Os c\u00e2nceres colorretais abrangem tumores que ocorrem tanto no c\u00f3lon quanto no reto.<\/li>\n\n\n\n<li>Um dos tipos de c\u00e2ncer mais comuns em todo o mundo: 10% da incid\u00eancia global de c\u00e2ncer em 2012.<\/li>\n\n\n\n<li>Terceiro tipo de c\u00e2ncer mais comum em homens (estima-se 746.000 novos casos por ano).<\/li>\n\n\n\n<li>Segundo tipo mais comum em mulheres (estimativa de 614.000 novos casos por ano).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Informa\u00e7\u00f5es sobre o carcinoma pancre\u00e1tico*<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Devido ao seu progn\u00f3stico reservado, o c\u00e2ncer de p\u00e2ncreas \u00e9 a s\u00e9tima causa mais comum de morte por c\u00e2ncer em todo o mundo.<\/li>\n\n\n\n<li>Estima-se que seja o 12\u00ba c\u00e2ncer mais comum em homens (178.000 casos) e o 11\u00ba mais comum em mulheres (160.000 casos) em todo o mundo em 2012.<\/li>\n\n\n\n<li>Dos novos casos, 68% ocorreram em pa\u00edses com n\u00edveis de desenvolvimento econ\u00f4mico humano altos ou muito altos.<\/li>\n\n\n\n<li>Estima-se que houve 330.000 mortes por c\u00e2ncer de p\u00e2ncreas em 2012.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">*Fonte: Estimativas <a href=\"https:\/\/www.drugsandalcohol.ie\/28525\/1\/WorldCancerReport.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">do Relat\u00f3rio Mundial do C\u00e2ncer da OMS de 2014<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<h5 class=\"wp-block-heading\">Recursos<\/h5>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links \u00fateis<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03871790?term=picop&amp;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">Descubra como voc\u00ea pode participar: ClinicalTrials.gov<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"http:\/\/sospk.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sociedade de Oncologia Cir\u00fargica do Paquist\u00e3o<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.drugsandalcohol.ie\/28525\/1\/World%20Cancer%20Report.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Relat\u00f3rio Mundial do C\u00e2ncer da OMS de 2014<\/a><\/p>\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n  <section class=\"bloque-personalizado bloque-contact-info\" >     \n    <h2 class=\"mt-3 mb-5\"> Entre em contato com o estudo PiCoP-GLOBAL.<\/h2>   \n    <div class=\"row justify-content-center bordesverticales\"> \n        <div class=\"bl-texto col-12 col-md-3\">\n         <h5 class=\"mt-0\">Para obter mais informa\u00e7\u00f5es, entre em contato.<\/h5>\n<p><strong>Prof. Dr. Peter Bauer, L\u00edder do Projeto<\/strong><br \/>\nCENTOGENE GmbH<br \/>\nNa Praia 7<br \/>\n18055 Rostock<br \/>\nAlemanha<br \/>\nE-mail:<a title=\"Escreva um e-mail\" href=\"mailto:peter.bauer@centogene.com\" > peter.bauer@centogene.com<\/a><\/p>\n<p><strong>Dra. Susann Krake, gerente de projeto<\/strong>r<br \/>\nCENTOGENE GmbH<br \/>\nNa Praia 7<br \/>\n18055 Rostock<br \/>\nAlemanha<br \/>\nE-mail: <a title=\"Escreva um e-mail\" href=\"mailto:susann.krake@centogene.com\">susann.krake@centogene.com<\/a><\/p>\n        <\/div>\n        <div class=\"bl-texto  col-12 col-md-2\">\n          \n        <\/div>\n        <div class=\"bl-texto  col-12 col-md-3\">\n          <h5 class=\"mt-0\">Ensaios cl\u00ednicos<\/h5>\n<h4 class=\"translation-block\">Acesso ao estudo no <sup>CentoPortal\u00ae<\/sup> para m\u00e9dicos participantes.<\/h4>\n<p><a class=\"btn btn-primary\" title=\"CentoPortal\" href=\"https:\/\/login.centoportal.com\/\" target=\"_blank\" rel=\"noopener noreferrer\">CentoPortal<\/a><\/p>\n        <\/div>\n    <\/div>\n  <\/section>  \n\n  \n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":1078,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-824","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PiCoP-GLOBAL | CENTOGENE<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.centogene.com\/pt\/farmaceutica\/apoio-a-ensaios-clinicos\/imunizacao-baseada-em-peptideos-para-carcinoma-de-colon-e-pancreas-picop-global\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PiCoP-GLOBAL | CENTOGENE\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.centogene.com\/pt\/farmaceutica\/apoio-a-ensaios-clinicos\/imunizacao-baseada-em-peptideos-para-carcinoma-de-colon-e-pancreas-picop-global\/\" \/>\n<meta property=\"og:site_name\" content=\"CENTOGENE\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-03T17:18:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/csm_centogene-diagnostics-priority-disease-03_5a57c07603.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"740\" \/>\n\t<meta property=\"og:image:height\" content=\"416\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.centogene.com\\\/pharma\\\/clinical-trial-support\\\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\\\/\",\"url\":\"https:\\\/\\\/www.centogene.com\\\/pharma\\\/clinical-trial-support\\\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\\\/\",\"name\":\"PiCoP-GLOBAL | CENTOGENE\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.centogene.com\\\/#website\"},\"datePublished\":\"2025-02-27T10:21:55+00:00\",\"dateModified\":\"2025-04-03T17:18:51+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.centogene.com\\\/pharma\\\/clinical-trial-support\\\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\\\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.centogene.com\\\/pharma\\\/clinical-trial-support\\\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.centogene.com\\\/pharma\\\/clinical-trial-support\\\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.centogene.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pharma\",\"item\":\"https:\\\/\\\/www.centogene.com\\\/pharma\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Clinical Trial Support\",\"item\":\"https:\\\/\\\/www.centogene.com\\\/pharma\\\/clinical-trial-support\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"PiCoP-GLOBAL\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.centogene.com\\\/#website\",\"url\":\"https:\\\/\\\/www.centogene.com\\\/\",\"name\":\"CENTOGENE\",\"description\":\"Guiding Precision Medicine\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.centogene.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.centogene.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.centogene.com\\\/#organization\",\"name\":\"CENTOGENE\",\"url\":\"https:\\\/\\\/www.centogene.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/www.centogene.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.centogene.com\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/CENTOGENE-Flower.png\",\"contentUrl\":\"https:\\\/\\\/www.centogene.com\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/CENTOGENE-Flower.png\",\"width\":246,\"height\":246,\"caption\":\"CENTOGENE\"},\"image\":{\"@id\":\"https:\\\/\\\/www.centogene.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.linkedin.com\\\/company\\\/centogene\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UClZxtN_laC1_ZtCdxkasdPQ\",\"https:\\\/\\\/www.instagram.com\\\/_centogene_\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"PiCoP-GLOBAL | CENTOGENE","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.centogene.com\/pt\/farmaceutica\/apoio-a-ensaios-clinicos\/imunizacao-baseada-em-peptideos-para-carcinoma-de-colon-e-pancreas-picop-global\/","og_locale":"pt_BR","og_type":"article","og_title":"PiCoP-GLOBAL | CENTOGENE","og_url":"https:\/\/www.centogene.com\/pt\/farmaceutica\/apoio-a-ensaios-clinicos\/imunizacao-baseada-em-peptideos-para-carcinoma-de-colon-e-pancreas-picop-global\/","og_site_name":"CENTOGENE","article_modified_time":"2025-04-03T17:18:51+00:00","og_image":[{"width":740,"height":416,"url":"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/csm_centogene-diagnostics-priority-disease-03_5a57c07603.webp","type":"image\/webp"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. tempo de leitura":"4 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.centogene.com\/pharma\/clinical-trial-support\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\/","url":"https:\/\/www.centogene.com\/pharma\/clinical-trial-support\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\/","name":"PiCoP-GLOBAL | CENTOGENE","isPartOf":{"@id":"https:\/\/www.centogene.com\/#website"},"datePublished":"2025-02-27T10:21:55+00:00","dateModified":"2025-04-03T17:18:51+00:00","breadcrumb":{"@id":"https:\/\/www.centogene.com\/pharma\/clinical-trial-support\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\/#breadcrumb"},"inLanguage":"pt-BR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.centogene.com\/pharma\/clinical-trial-support\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.centogene.com\/pharma\/clinical-trial-support\/peptide-based-immunization-for-colon-and-pancreas-carcinoma-picop-global\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.centogene.com\/"},{"@type":"ListItem","position":2,"name":"Pharma","item":"https:\/\/www.centogene.com\/pharma\/"},{"@type":"ListItem","position":3,"name":"Clinical Trial Support","item":"https:\/\/www.centogene.com\/pharma\/clinical-trial-support\/"},{"@type":"ListItem","position":4,"name":"PiCoP-GLOBAL"}]},{"@type":"WebSite","@id":"https:\/\/www.centogene.com\/#website","url":"https:\/\/www.centogene.com\/","name":"CENTOGENE","description":"Orientando a Medicina de Precis\u00e3o","publisher":{"@id":"https:\/\/www.centogene.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.centogene.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt-BR"},{"@type":"Organization","@id":"https:\/\/www.centogene.com\/#organization","name":"CENTOGENE","url":"https:\/\/www.centogene.com\/","logo":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/www.centogene.com\/#\/schema\/logo\/image\/","url":"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/04\/CENTOGENE-Flower.png","contentUrl":"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/04\/CENTOGENE-Flower.png","width":246,"height":246,"caption":"CENTOGENE"},"image":{"@id":"https:\/\/www.centogene.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.linkedin.com\/company\/centogene","https:\/\/www.youtube.com\/channel\/UClZxtN_laC1_ZtCdxkasdPQ","https:\/\/www.instagram.com\/_centogene_\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.centogene.com\/pt\/wp-json\/wp\/v2\/pages\/824","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.centogene.com\/pt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.centogene.com\/pt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.centogene.com\/pt\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.centogene.com\/pt\/wp-json\/wp\/v2\/comments?post=824"}],"version-history":[{"count":0,"href":"https:\/\/www.centogene.com\/pt\/wp-json\/wp\/v2\/pages\/824\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.centogene.com\/pt\/wp-json\/wp\/v2\/pages\/1078"}],"wp:attachment":[{"href":"https:\/\/www.centogene.com\/pt\/wp-json\/wp\/v2\/media?parent=824"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}