{"id":621,"date":"2025-02-25T16:41:08","date_gmt":"2025-02-25T16:41:08","guid":{"rendered":"http:\/\/centogene.vl22350.dinaserver.com\/?page_id=621"},"modified":"2025-04-03T17:36:01","modified_gmt":"2025-04-03T17:36:01","slug":"choroba-parkinsona","status":"publish","type":"page","link":"https:\/\/www.centogene.com\/pl\/resources\/key-diseases\/parkinsons-disease\/","title":{"rendered":"Choroba Parkinsona"},"content":{"rendered":"<section class=\"bloque-banner-titulo-page  estilo-grey\" id=\"\">\r\n    \r\n    <div class=\"image-wrapper\">\r\n\r\n      <!-- include mp4 video on a loop -->\r\n              <img decoding=\"async\" class=\"\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/csm_centogene-diagnostics-priority-disease-04_cccd63ddb4.webp\" alt=\"csm_centogene-diagnostyka-priorytet-choroba-04_cccd63ddb4\" \/>\r\n          <\/div>\r\n    <div class=\"container content-wrapper\">\r\n      <div class=\"row justify-content-start align-items-center\">\r\n\r\n\r\n        <div class=\"col-12 col-lg-6 animation fadeTop align-self-center\">\r\n                  <h1>Choroba Parkinsona<\/h1>\r\n          <h2 class=\"bl-texto\">Choroba Parkinsona (PD) jest post\u0119puj\u0105c\u0105 chorob\u0105 neurodegeneracyjn\u0105, kt\u00f3ra dotyka oko\u0142o 2 % populacji w wieku powy\u017cej 60 lat. <\/h2>                            <\/div>\r\n\r\n      <\/div>\r\n    <\/div>\r\n\r\n<\/section>\r\n<div class=\"breadcrumbs\">\r\n    <div class=\"container\">\r\n      <div class=\"row\">\r\n        <div class=\"col-12\">\r\n          <ul id=\"breadcrumbs\" class=\"breadcrumbs\"><li><a href=\"https:\/\/www.centogene.com\/pl\/\">Dom<\/a><\/li><\/ul>        <\/div>\r\n      <\/div>\r\n    <\/div>\r\n<\/div>\r\n\r\n\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente-my\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Czym jest choroba Parkinsona?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Choroba Parkinsona (PD) jest post\u0119puj\u0105c\u0105 chorob\u0105 neurodegeneracyjn\u0105, kt\u00f3ra dotyka oko\u0142o 2 % populacji w wieku powy\u017cej 60 lat. Je\u015bli choroba zaczyna si\u0119 przed 21. rokiem \u017cycia, m\u00f3wi si\u0119 o m\u0142odzie\u0144czej postaci PD. Je\u015bli objawy pojawiaj\u0105 si\u0119 przed 50. rokiem \u017cycia, chorob\u0119 okre\u015bla si\u0119 jako PD o wczesnym pocz\u0105tku. Choroba wi\u0105\u017ce si\u0119 z szerokim spektrum objaw\u00f3w ruchowych i pozaruchowych. Charakterystyczne zmiany patologiczne to utrata neuron\u00f3w w okre\u015blonych obszarach istoty czarnej \u015br\u00f3dm\u00f3zgowia oraz rozleg\u0142e wewn\u0105trzkom\u00f3rkowe gromadzenie si\u0119 bia\u0142ka \u03b1-synukleiny. Do g\u0142\u00f3wnych objaw\u00f3w ruchowych nale\u017c\u0105 dr\u017cenie, sztywno\u015b\u0107 mi\u0119\u015bni i bradykinezja.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Od lat 90. XX wieku naukowcy zidentyfikowali kilka g\u0142\u00f3wnych wariant\u00f3w genetycznych, kt\u00f3re zwi\u0119kszaj\u0105 ryzyko rozwoju PD. Obecnie dost\u0119pna jest obszerna literatura naukowa dotycz\u0105ca cz\u0119sto\u015bci wyst\u0119powania tych wariant\u00f3w w r\u00f3\u017cnych populacjach oraz ich wp\u0142ywu na fenotyp i przebieg kliniczny choroby.<sup>123<\/sup>&nbsp;<\/h3>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Na \u015bwiecie tylko 15&nbsp;% pacjent\u00f3w zg\u0142asza wyst\u0119powanie objaw\u00f3w PD w rodzinie. Pozosta\u0142e 85&nbsp;% przypadk\u00f3w PD klasyfikuje si\u0119 jako sporadyczne.<sup>4<\/sup> Znane mutacje przyczynowe wyst\u0119puj\u0105 rzadko, u mniej ni\u017c 2&nbsp;% pacjent\u00f3w z PD. Dwa najcz\u0119\u015bciej zmutowane geny zwi\u0105zane z rodzinn\u0105 postaci\u0105 PD to <em>LRRK2<\/em> i <em>PRKN<\/em>. Ich mutacje stwierdza si\u0119 odpowiednio u 0,7&nbsp;% i 0,3&nbsp;% wszystkich os\u00f3b z objawami PD.<sup>4<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Granica mi\u0119dzy genetyczn\u0105 a sporadyczn\u0105 postaci\u0105 PD jest jednak nieostra. \u017badna mutacja w pojedynczym genie zwi\u0105zana z PD nie wykazuje 100 % penetracji. Prawdopodobnie wiele genetycznych czynnik\u00f3w ryzyka dzia\u0142a synergistycznie i zwi\u0119ksza ryzyko zar\u00f3wno rodzinnej, jak i sporadycznej postaci PD. Taka podatno\u015b\u0107 genetyczna wchodzi w interakcje ze starzeniem si\u0119 organizmu i czynnikami \u015brodowiskowymi, co prowadzi do rozwoju choroby.<sup>&nbsp;4<\/sup><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocaja\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h5 class=\"wp-block-heading\">Objawy<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Uboga mimika twarzy<\/li>\n\n\n\n<li>Zaburzenia snu<\/li>\n\n\n\n<li>Zaburzenia ruch\u00f3w ga\u0142ek ocznych<\/li>\n\n\n\n<li>Zaburzenia sensoryczne, np. os\u0142abienie w\u0119chu<\/li>\n\n\n\n<li>Objawy dysfunkcji autonomicznej (zaparcia, zaburzenia pocenia, dysfunkcja seksualna, \u0142ojotokowe zapalenie sk\u00f3ry)<\/li>\n\n\n\n<li>Os\u0142abienie, zm\u0119czenie<\/li>\n\n\n\n<li>Depresja lub anhedonia<\/li>\n\n\n\n<li>Dr\u017cenie<\/li>\n\n\n\n<li>Niestabilno\u015b\u0107 postawy<\/li>\n\n\n\n<li>Zmniejszone wsp\u00f3\u0142ruchy ko\u0144czyny g\u00f3rnej podczas chodu po stronie, po kt\u00f3rej objawy pojawi\u0142y si\u0119 najpierw<\/li>\n\n\n\n<li>Demencja<\/li>\n\n\n\n<li>Napady drgawkowe<\/li>\n<\/ul>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocolor\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n    <section class=\"bloque-personalizado bloque-cajas-imgs estilo-cajasblancas\" >\n        <div class=\"\"> \n            <div class=\"ref-arrows\" >             <div class=\"caja-wrapper-588 swiper\">\n\n            <div class=\"swiper-wrapper\" >                             \n                <div class=\"swiper-slide col-12 col-md-4 delay-1 caja\">\n                    <div class=\"caja-inner\" >\n                        <a href=\"https:\/\/www.centogene.com\/pl\/farmaceutyka\/wsparcie-badan-klinicznych\/rostock-miedzynarodowe-badanie-choroby-parkinsona-ropad\/\" target=\"_self\" class=\"\">                        <div class=\"bl-imagen animationNo scalexTop delay-1\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/csm_centogene-pharma-clinical-trails_ROPAD-header_a8e1a19396-650x400.webp\" class=\"\" alt=\"\" \/> <\/div>                                               \n                        <\/a>                        \n                        <div class=\"caja-text\">\n                            <p class=\"prefijo\">Dla firm farmaceutycznych<\/p>                            <h3 class=\"bl-titulo\">Badanie ROPAD<\/h3>\n                            <p class=\"translation-block\">CENTOGENE wsp\u00f3\u0142pracuje z <a href=\"https:\/\/www.centogene.com\/pl\/wydarzenia-informacyjne\/aktualnosci\/newsdetails\/centogene-i-denali-therapics-oglaszaja-strategiczna-wspolprace-w-celu-rekrutacji-pacjentow-z-lrrk2-do-badan-klinicznych\/\" target=\"_self\">Uniwersytetem w Lubece i firm\u0105 Denali Therapeutics<\/a> przy <a title=\"Badanie ROPAD\" href=\"https:\/\/www.centogene.com\/pl\/farmaceutyka\/wsparcie-badan-klinicznych\/rostock-miedzynarodowe-badanie-choroby-parkinsona-ropad\/\" target=\"_self\">badaniu<\/a>, kt\u00f3rego celem jest identyfikacja pacjent\u00f3w z PD b\u0119d\u0105cych nosicielami wariantu w genie <em>LRRK2<\/em>. Badanie ma na celu oszacowanie cz\u0119sto\u015bci wyst\u0119powania wariant\u00f3w w genie <em>LRRK2<\/em> oraz w innych powi\u0105zanych genach w kohorcie pacjent\u00f3w z PD, a tak\u017ce poszukiwanie potencjalnych biomarker\u00f3w. W razie pyta\u0144 dotycz\u0105cych badania lub zainteresowania wsp\u00f3\u0142prac\u0105 z CENTOGENE w zakresie bada\u0144 nad potencjalnymi terapiami prosimy o kontakt z naszym zespo\u0142em odpowiedzialnym za <a title=\"Badanie ROPAD\" href=\"https:\/\/www.centogene.com\/pl\/farmaceutyka\/wsparcie-badan-klinicznych\/rostock-miedzynarodowe-badanie-choroby-parkinsona-ropad\/\" target=\"_self\">badanie ROPAD<\/a>.<\/p>\n      \n                                                          <a target=\"_self\" href=\"https:\/\/www.centogene.com\/pl\/farmaceutyka\/wsparcie-badan-klinicznych\/rostock-miedzynarodowe-badanie-choroby-parkinsona-ropad\/\" class=\"btn btn-primary\">Dowiedz si\u0119 wi\u0119cej o naszym badaniu<\/a>\n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                            \n                <div class=\"swiper-slide col-12 col-md-4 delay-1 delay-2 caja\">\n                    <div class=\"caja-inner\" >\n                        <a href=\"https:\/\/www.centogene.com\/pl\/diagnostyka\/panele-ngs\/\" target=\"_self\" class=\"\">                        <div class=\"bl-imagen animationNo scalexTop delay-2\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/csm_centogene-diagnostics_ngs-panels-header_a925dbebd1-650x400.webp\" class=\"\" alt=\"\" \/> <\/div>                                               \n                        <\/a>                        \n                        <div class=\"caja-text\">\n                            <p class=\"prefijo\">Lekarze<\/p>                            <h3 class=\"bl-titulo\">Panele NGS<\/h3>\n                            <p class=\"translation-block\"><a title=\"Panele NGS\" href=\"https:\/\/www.centogene.com\/pl\/diagnostyka\/panele-ngs\/\" target=\"_self\">Panele NGS<\/a> CENTOGENE w kierunku dziedzicznych postaci PD zosta\u0142y starannie zaprojektowane tak, aby identyfikowa\u0107 warianty genetyczne istotne patogenetycznie.<\/p>\n      \n                                                          <a target=\"_self\" href=\"https:\/\/www.centogene.com\/pl\/diagnostyka\/panele-ngs\/\" class=\"btn btn-primary\">Dowiedz si\u0119 wi\u0119cej o naszych panelach NGS<\/a>\n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                            \n                <div class=\"swiper-slide col-12 col-md-4 delay-1 delay-2 delay-3 caja\">\n                    <div class=\"caja-inner\" >\n                        <a href=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/centogene_downloads_cheatsheet_V2eng_Print_Web_20200706.pdf\" target=\"_blank\" class=\"\">                        <div class=\"bl-imagen animationNo scalexTop delay-3\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/csm_centogene-patients_what-we-do-for-patients-header-01_5410842a2a-650x400.webp\" class=\"\" alt=\"\" \/> <\/div>                                               \n                        <\/a>                        \n                        <div class=\"caja-text\">\n                            <p class=\"prefijo\">Pacjenci<\/p>                            <h3 class=\"bl-titulo\">Poradnictwo genetyczne<\/h3>\n                            <p>CENTOGENE wykonuje wy\u0142\u0105cznie badania genetyczne zlecone przez lekarza. Wyniki bada\u0144 genetycznych mog\u0105 mie\u0107 du\u017cy wp\u0142yw na \u017cycie pacjenta i jego rodziny, dlatego zdecydowanie zalecamy skorzystanie z poradnictwa genetycznego. Specjali\u015bci poradnictwa genetycznego pomog\u0105 Pa\u0144stwu i Pa\u0144stwa rodzinie oceni\u0107, czy warto wykona\u0107 badanie genetyczne, a tak\u017ce zrozumie\u0107 jego wyniki i ich konsekwencje.<\/p>\n<p>Poni\u017csze pytania i odpowiedzi mog\u0105 okaza\u0107 si\u0119 pomocne w rozmowie z lekarzem na temat bada\u0144 genetycznych:<\/p>\n      \n                                                          <a target=\"_blank\" href=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/centogene_downloads_cheatsheet_V2eng_Print_Web_20200706.pdf\" class=\"btn btn-primary\">O co pyta\u0107 lekarza<\/a>\n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                                    <\/div>\n            <div class=\"swiper-pagination\"><\/div>\n\n          <\/div>\n          <div class=\"swiper-button-prev pre-588\"><\/div>\n          <div class=\"swiper-button-next next-588\"><\/div>   \n                       \n             \n            \n        <\/div>\n    <\/div>  \n<\/section>\n\n\n\n<script>\n    jQuery(document).ready(function(){\n    var swiper = new Swiper(\".caja-wrapper-588\", {\n      slidesPerView: 1,\n      spaceBetween: 10, \n      navigation: {\n        nextEl: \".next-588\",\n        prevEl: \".pre-588\",\n      },\n      \/\/navigation: false,\n      pagination: {\n        el: \".swiper-pagination\",\n        clickable: true\n      },\n      loop: false,\n      autoplay: {\n        delay: 2500,\n        disableOnInteraction: true,\n      },\n      breakpoints: {\n        640: {\n          slidesPerView: 1,\n          spaceBetween: 10,\n        },\n        768: {\n          slidesPerView: 2,\n          spaceBetween: 40,\n        },\n        1024: {\n          slidesPerView: 3,\n          spaceBetween: 40,\n        },\n        1200: {\n          slidesPerView: 3,\n          spaceBetween: 40,\n        },\n      },\n      on: {\n      slideChange: function(){\n          \/\/code\n      }\n    }\n    });\n});\n<\/script>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente-my\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                        <div class=\"row\">\r\n                <div class=\"col-12  col-md-8\">                     \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h5 class=\"wp-block-heading\">Przypisy<\/h5>\n\n\n\n<p class=\"wp-block-paragraph\"><sup>1<\/sup>Escott-Price, V. i in. Ryzyko poligeniczne choroby Parkinsona koreluje z wiekiem zachorowania. Ann. Neurol. 77 (4), kwiecie\u0144 2015, 582-91, doi: 10.1002\/ana.24335.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><sup>2<\/sup>Sim\u00f3n-S\u00e1nchez, J. i in. Badanie asocjacyjne ca\u0142ego genomu ujawnia ryzyko genetyczne le\u017c\u0105ce u pod\u0142o\u017ca choroby Parkinsona. Nat. Genet. 41 (12), grudzie\u0144 2009, 1308\u20131312, doi: 10.1038\/ng.487<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><sup>3<\/sup>Chang, D. i in. Metaanaliza bada\u0144 asocjacyjnych w ca\u0142ym genomie zidentyfikowa\u0142a 17 nowych loci ryzyka choroby Parkinsona. Nat. Genet. 49(10), pa\u017adziernik 2017, 1511\u20131516. doi: 10.1038\/ng.3955.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><sup>4<\/sup>Tran, J., Anastacio, H. i Bardy, C. Predyspozycje genetyczne do choroby Parkinsona ujawnione w kom\u00f3rkach m\u00f3zgowych pochodz\u0105cych od pacjent\u00f3w. npj Parkinsons Dis. 6, 8, kwiecie\u0144 2020, doi.org\/10.1038\/s41531-020-0110-8<\/p>\n\n<\/div>\r\n          \r\n                                <\/div>\r\n            <\/div>            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n  <section class=\"bloque-personalizado bloque-contact-info\" >     \n    <h2 class=\"mt-3 mb-5\"><div style=\"margin: 3rem 0 \">Jeste\u015bmy tutaj, aby Ci\u0119 prowadzi\u0107<p style=\"font-size: 1.2rem; margin-top: 1rem; margin-bottom: 1.5rem;\">Nasz globalny zesp\u00f3\u0142 obs\u0142ugi klienta i ekspert\u00f3w b\u0119dzie Ci\u0119 wspiera\u0107 na ka\u017cdym kroku.<\/p><a class=\"btn btn-primary\" style=\"margin: .5rem\" href=\"mailto:customer.support@centogene.com\">Wy\u015blij nam wiadomo\u015b\u0107<\/a><a class=\"btn btn-2\" style=\"margin: .5rem\" href=\"https:\/\/www.centogene.com\/pl\/o-nas\/skontaktuj-sie-z-nami\/\">Wsparcie regionalne<\/a><\/div><\/h2>   \n    <div class=\"row justify-content-center bordesverticales\"> \n        <div class=\"bl-texto col-12 col-md-3\">\n                 <\/div>\n        <div class=\"bl-texto  col-12 col-md-2\">\n          \n        <\/div>\n        <div class=\"bl-texto  col-12 col-md-3\">\n                  <\/div>\n    <\/div>\n  <\/section>  \n\n  \n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":2035,"menu_order":50,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-621","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Parkinson\u2019s Disease | CENTOGENE<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.centogene.com\/pl\/zasoby\/kluczowe-choroby\/choroba-parkinsona\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Parkinson\u2019s Disease | CENTOGENE\" \/>\n<meta property=\"og:url\" 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