{"id":11101,"date":"2026-10-20T17:36:16","date_gmt":"2026-10-20T17:36:16","guid":{"rendered":"https:\/\/www.centogene.com\/?page_id=11101"},"modified":"2026-10-26T16:00:50","modified_gmt":"2026-10-26T16:00:50","slug":"centobiom","status":"publish","type":"page","link":"https:\/\/www.centogene.com\/pl\/reproductive-health\/centobiome\/","title":{"rendered":"CentoBiome"},"content":{"rendered":"\r\n<section class=\"bloque-banner-titulo-page  estilo-grey \" id=\"\">\r\n    \r\n    <div class=\"image-wrapper\">\r\n\r\n      <!-- include mp4 video on a loop -->\r\n              <img decoding=\"async\" class=\"\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/CentoBiome_Photo_Circle_v2-1024x1024.png\" alt=\"CentoBiome_Photo_Circle_v2\" \/>\r\n          <\/div>\r\n    <div class=\"container content-wrapper\">\r\n      <div class=\"row justify-content-start align-items-center\">\r\n\r\n\r\n        <div class=\"col-12 col-lg-6 animation fadeTop align-self-center \">\r\n                  <h1>CentoBiome<\/h1>\r\n          <h2 class=\"bl-texto \">Minimally Invasive Endometrial\r\nMicrobiome test<\/h2>                            <\/div>\r\n\r\n      <\/div>\r\n    <\/div>\r\n\r\n<\/section>\r\n<div class=\"breadcrumbs\">\r\n    <div class=\"container\">\r\n      <div class=\"row\">\r\n        <div class=\"col-12\">\r\n          <ul id=\"breadcrumbs\" class=\"breadcrumbs\"><li><a href=\"https:\/\/www.centogene.com\">Home<\/a><\/li><\/ul>        <\/div>\r\n      <\/div>\r\n    <\/div>\r\n<\/div>\r\n\r\n\r\n\n\n\r\n    \r\n\r\n<section class=\" bloque-contenedor    transparente-my \"   id=\"\">\r\n    <div class=\" container \">\r\n        <div class=\"  \"> \r\n                        <div class=\" row\">\r\n                <div class=\" col-12  col-md-10 mx-auto \">                     \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"543\" height=\"543\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/CENTOGENE-Flower-Heart.svg\" alt=\"\" class=\"wp-image-7655\" style=\"width:75px;height:auto\"\/><\/figure>\n\n\n\n<p class=\"has-text-align-center has-larger-font-size wp-block-paragraph\"><br><strong>Endometrial microbiome testing to support personalized fertility care. <\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center has-larger-font-size wp-block-paragraph\">CentoBiome is a minimally invasive molecular test that detects and quantifies clinically relevant microorganisms in endometrial fluid, providing actionable information to support personalized reproductive care.<\/p>\n\n\n\n<p class=\"has-text-align-center has-larger-font-size wp-block-paragraph\">Growing evidence suggests that alterations of the endometrial microbiome may contribute to implantation failure, recurrent pregnancy loss and other adverse reproductive outcomes<sup>1,2<\/sup><\/p>\n\n\n\n<div style=\"height:57px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph\">1. Moreno et al., Am J Obstet Gynecol (2016). 2. Moreno, Garc\u00eda-Grau et al., Microbiome (2022).<\/p>\n\n<\/div>\r\n          \r\n                                <\/div>\r\n            <\/div>            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\" bloque-contenedor  gutter-xl  transparente \"   id=\"\">\r\n    <div class=\" container \">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Who can benefit from this test?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">CentoBiome is especially indicated for women wishing to conceive, particularly those with:<br><br><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-texto-color has-text-color has-link-color wp-elements-1 is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:91px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Recurrent implantation<br>failure (RIF)<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:91px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Recurrent pregnancy<br>loss (RPL)<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:91px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Previous pregnancies<br>complicated by<br>intrauterine infections<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:91px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Suspected endometrial<br>dysbiosis or chronic<br>endometritis<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:91px\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Limited embryo<br>number available<\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Provides clinically relevant microbiological information to complement the evaluation of the endometrial factor and support individualized reproductive management.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><br><br><\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full is-resized mb-4 mt-2\"><img loading=\"lazy\" decoding=\"async\" width=\"2400\" height=\"2400\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/CENTOGENE_Uterus_Icon_Circle_2400px.png\" alt=\"\" class=\"wp-image-11392\" style=\"width:366px;height:auto\" srcset=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/CENTOGENE_Uterus_Icon_Circle_2400px.png 2400w, https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/CENTOGENE_Uterus_Icon_Circle_2400px-800x800.png 800w, https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/CENTOGENE_Uterus_Icon_Circle_2400px-1024x1024.png 1024w, https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/CENTOGENE_Uterus_Icon_Circle_2400px-768x768.png 768w, https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/CENTOGENE_Uterus_Icon_Circle_2400px-1536x1536.png 1536w, https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/CENTOGENE_Uterus_Icon_Circle_2400px-2048x2048.png 2048w, https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/CENTOGENE_Uterus_Icon_Circle_2400px-12x12.png 12w\" sizes=\"auto, (max-width: 2400px) 100vw, 2400px\" \/><\/figure>\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\" bloque-contenedor    fondocolor \"   id=\"testingoptions\">\r\n    <div class=\" container \">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\r\n    \r\n\r\n<section class=\" bloque-contenedor    fondocaja \"   id=\"\">\r\n    <div class=\" container \">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h3 class=\"wp-block-heading has-text-align-left\">How to collect the Sample?<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"100\" height=\"100\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/ico-sample.svg\" alt=\"\" class=\"wp-image-11193\" style=\"width:100px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">Aspiration of endometrial fluid (~50 \u03bcl) using an embryo transfer catheter, reducing patient discomfort and minimizing impact on the uterine environment or ART timeline.<\/p>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\r\n    \r\n\r\n<section class=\" bloque-contenedor    fondocaja \"   id=\"\">\r\n    <div class=\" container \">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h3 class=\"wp-block-heading has-text-align-left\">When to collect the sample?<\/h3>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image alignright size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"100\" height=\"100\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/ico-papers.svg\" alt=\"\" class=\"wp-image-11192\" style=\"width:100px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">During the secretory phase, when the endometrial microbiota is most stable and the endometrium is naturally receptive to embryo implantation.<\/p>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\" bloque-contenedor    transparente-my \"   id=\"\">\r\n    <div class=\" container \">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h2 class=\"wp-block-heading has-text-align-center\">Why CentoBiome?<\/h2>\n\n\n\n<p class=\"has-text-align-center has-large-font-size wp-block-paragraph\">CentoBiome provides standardized, clinically interpretable results to improve women&#8217;s reproductive healthcare.<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><strong>Minimally invasive endometrial<br>fluid <\/strong>sampling.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><strong>Faster Turnaround Time<\/strong><br>7 business days.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><strong>Optimized clinical workflow<\/strong><br>room-temperature sample transport<br>and standardized laboratory analysis.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><strong>Species-level quantitative<br>detection.<\/strong><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><strong>Evidence-based microorganism<br>panel <\/strong>specifically designed for<br>female reproductive health.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/02\/ico-red-check.svg\" alt=\"\" class=\"wp-image-7670\" style=\"width:30px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:1rem\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Clinically meaningful result categories<\/strong><br>with actionable reporting to facilitate<br>result interpretation and support<br>therapeutic decision-making.<\/p>\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\" bloque-contenedor    fondocolor pb-0\"   id=\"\">\r\n    <div class=\" container \">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h2 class=\"wp-block-heading has-text-align-center\">Targeted &amp; Quantitative Microorganism Profiling<\/h2>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size wp-block-paragraph\">Comprehensive profiling of clinically relevant microorganisms, including those associated with endometrial dysbiosis, chronic endometritis, sexually transmitted infections, and beneficial Lactobacillus species.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-align-center\"><strong>What to Expect? Result Categories<\/strong><\/h3>\n\n\n    <section class=\"bloque-personalizado bloque-cajas-imgs estilo-cajasiconos\" >\n        <div class=\" \"> \n                        <div class=\" row justify-content-between \">\n\n                                        \n                <div class=\"swiper-slide col-12 col-md-4 delay-1 caja\">\n                    <div class=\"caja-inner\" >\n                                                <div class=\"bl-imagen animationNo scalexTop delay-1\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/ico-eubiosis.svg\" class=\" \" alt=\"\" \/> <\/div>                                               \n                                                \n                        <div class=\"caja-text \">\n                                                        <h3 class=\" bl-titulo\">Eubiosis<\/h3>\n                            <p><em>Lactobacillus<\/em>-dominated profile consistent with endometrial microbial balance; no microbiological intervention is indicated.<\/p>\n      \n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                            \n                <div class=\"swiper-slide col-12 col-md-4 delay-1 delay-2 caja\">\n                    <div class=\"caja-inner\" >\n                                                <div class=\"bl-imagen animationNo scalexTop delay-2\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/ico-microbial.svg\" class=\" \" alt=\"\" \/> <\/div>                                               \n                                                \n                        <div class=\"caja-text \">\n                                                        <h3 class=\" bl-titulo\">Low microbial signal<\/h3>\n                            <p>Low bacterial signal with no evidence of microbial dysbiosis; probiotic strategies may be considered depending on the clinical context.<\/p>\n      \n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                            \n                <div class=\"swiper-slide col-12 col-md-4 delay-1 delay-2 delay-3 caja\">\n                    <div class=\"caja-inner\" >\n                                                <div class=\"bl-imagen animationNo scalexTop delay-3\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/ico-dysbiosis.svg\" class=\" \" alt=\"\" \/> <\/div>                                               \n                                                \n                        <div class=\"caja-text \">\n                                                        <h3 class=\" bl-titulo\">Dysbiosis<\/h3>\n                            <p>Predominance of potentially pathogenic microorganisms, consistent with altered endometrial microbial balance; personalized management may include targeted antimicrobial therapy and\/or probiotics according to clinical judgment.<\/p>\n      \n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                                     \n             \n            \n        <\/div>\n    <\/div>  \n<\/section>\n\n\n\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\" bloque-contenedor    transparente-my \"   id=\"\">\r\n    <div class=\" container \">\r\n        <div class=\"\"> \r\n                        <div class=\" row\">\r\n                <div class=\" col-12  col-md-8 mx-auto \">                     \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h2 class=\"wp-block-heading has-text-align-center\">Frequently Asked Questions: CentoBiome<\/h2>\n\n\n<section class=\" bloque-acordeon\" id=\"\">\n    <div class=\"accordion\" id=\"accordionBlock\">\n        <div class=\"acf-innerblocks-container\">\n\n<div class=\"accordion-item\" >\n    <h2 class=\"accordion-header\" id=\"heading-165\">\n      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#item-165\" aria-expanded=\"false\" aria-controls=\"item-165\">\n      Why might I need the CentoBiome test?      <\/button>\n    <\/h2>\n    <div id=\"item-165\" class=\"accordion-collapse collapse \" aria-labelledby=\"heading-165\" data-bs-parent=\"#accordionBlock\">\n      <div class=\"accordion-body\">\n        <div class=\"acf-innerblocks-container\">\n\n<p class=\"wp-block-paragraph\">CentoBiome looks at the balance of microorganisms in your uterus. Research suggests that changes in this balance may play a role in difficulties with embryo implantation and in pregnancy loss. Your doctor may recommend the test if you are trying to conceive, particularly if you have had unsuccessful embryo transfers, repeated pregnancy losses or previous intrauterine infections, or if you have a limited number of embryos available.<\/p>\n\n<\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n\n\n\n\n<div class=\"accordion-item\" >\n    <h2 class=\"accordion-header\" id=\"heading-589\">\n      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#item-589\" aria-expanded=\"false\" aria-controls=\"item-589\">\n      When should I get tested?      <\/button>\n    <\/h2>\n    <div id=\"item-589\" class=\"accordion-collapse collapse \" aria-labelledby=\"heading-589\" data-bs-parent=\"#accordionBlock\">\n      <div class=\"accordion-body\">\n        <div class=\"acf-innerblocks-container\">\n\n<p class=\"wp-block-paragraph\">The sample is collected in the second half of your menstrual cycle (the secretory phase). At this point the microorganisms in your uterus are most stable, and your uterus is naturally prepared to receive an embryo. Your doctor will plan the right timing with you.<\/p>\n\n<\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n\n\n\n\n<div class=\"accordion-item\" >\n    <h2 class=\"accordion-header\" id=\"heading-794\">\n      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#item-794\" aria-expanded=\"false\" aria-controls=\"item-794\">\n      What type of sample do I need to submit?      <\/button>\n    <\/h2>\n    <div id=\"item-794\" class=\"accordion-collapse collapse \" aria-labelledby=\"heading-794\" data-bs-parent=\"#accordionBlock\">\n      <div class=\"accordion-body\">\n        <div class=\"acf-innerblocks-container\">\n\n<p class=\"wp-block-paragraph\">Now with the new CentoBiome\u2019s minimally invasive sampling method, only a very small amount of fluid from inside your uterus is needed, about 50 \u00b5l. Your doctor collects it gently during a clinic visit, using a thin, flexible catheter like the one used for embryo transfer. No tissue sample is taken.<\/p>\n\n<\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n\n\n\n\n<div class=\"accordion-item\" >\n    <h2 class=\"accordion-header\" id=\"heading-974\">\n      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#item-974\" aria-expanded=\"false\" aria-controls=\"item-974\">\n      How long do the results take?      <\/button>\n    <\/h2>\n    <div id=\"item-974\" class=\"accordion-collapse collapse \" aria-labelledby=\"heading-974\" data-bs-parent=\"#accordionBlock\">\n      <div class=\"accordion-body\">\n        <div class=\"acf-innerblocks-container\">\n\n<p class=\"wp-block-paragraph\">Results are typically available within 7 business days after the laboratory receives your sample. [TO BE CONFIRMED: the starting point]<\/p>\n\n<\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n\n\n\n\n<div class=\"accordion-item\" >\n    <h2 class=\"accordion-header\" id=\"heading-291\">\n      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#item-291\" aria-expanded=\"false\" aria-controls=\"item-291\">\n      How are the results reported?      <\/button>\n    <\/h2>\n    <div id=\"item-291\" class=\"accordion-collapse collapse \" aria-labelledby=\"heading-291\" data-bs-parent=\"#accordionBlock\">\n      <div class=\"accordion-body\">\n        <div class=\"acf-innerblocks-container\">\n\n<p class=\"wp-block-paragraph\">Your result will fall into one of three categories:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Eubiosis (balanced): a healthy balance, mainly made up of beneficial Lactobacillus bacteria.<\/li>\n\n\n\n<li>Low microbial signal: few bacteria were detected, with no sign of imbalance.<\/li>\n\n\n\n<li>Dysbiosis (imbalanced): some potentially harmful microorganisms are more common than expected.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">The report goes to your doctor, who will explain what it means for you.<\/p>\n\n<\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n\n\n\n\n<div class=\"accordion-item\" >\n    <h2 class=\"accordion-header\" id=\"heading-705\">\n      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#item-705\" aria-expanded=\"false\" aria-controls=\"item-705\">\n      If my result shows an imbalance, what are my options?      <\/button>\n    <\/h2>\n    <div id=\"item-705\" class=\"accordion-collapse collapse \" aria-labelledby=\"heading-705\" data-bs-parent=\"#accordionBlock\">\n      <div class=\"accordion-body\">\n        <div class=\"acf-innerblocks-container\">\n\n<p class=\"wp-block-paragraph\">Your doctor will discuss whether any treatment is right for you, based on your result and your medical history. Depending on the situation, options may include targeted treatment and\/or probiotics.<\/p>\n\n<\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n\n\n\n\n<div class=\"accordion-item\" >\n    <h2 class=\"accordion-header\" id=\"heading-112\">\n      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#item-112\" aria-expanded=\"false\" aria-controls=\"item-112\">\n      Who can I talk to about my CentoBiome results?      <\/button>\n    <\/h2>\n    <div id=\"item-112\" class=\"accordion-collapse collapse \" aria-labelledby=\"heading-112\" data-bs-parent=\"#accordionBlock\">\n      <div class=\"accordion-body\">\n        <div class=\"acf-innerblocks-container\">\n\n<p class=\"wp-block-paragraph\">Your fertility specialist, who ordered the test, will review the results with you and recommend next steps.<\/p>\n\n<\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n\n\n\n\n<div class=\"accordion-item\" >\n    <h2 class=\"accordion-header\" id=\"heading-702\">\n      <button class=\"accordion-button collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#item-702\" aria-expanded=\"false\" aria-controls=\"item-702\">\n      How do I request CentoBiome?      <\/button>\n    <\/h2>\n    <div id=\"item-702\" class=\"accordion-collapse collapse \" aria-labelledby=\"heading-702\" data-bs-parent=\"#accordionBlock\">\n      <div class=\"accordion-body\">\n        <div class=\"acf-innerblocks-container\">\n\n<p class=\"wp-block-paragraph\">Ask your fertility specialist. Clinics can order the test through the CENTOGENE IVF ordering portal selected by region.<\/p>\n\n<\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n\n\n<\/div>\n    <\/div>\n<\/section>\n\n<\/div>\r\n          \r\n                                <\/div>\r\n            <\/div>            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\" bloque-contenedor    fondocolor \"   id=\"\">\r\n    <div class=\" container \">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\r\n\r\n\r\n<section class=\" bloque-tabs-resources\" id=\"tabs-group-822\">\r\n<h2 class=\"text-center mt-0\"> Additional Information &#038; Resources<\/h2>\r\n    <div class=\"tab-content\" id=\"tab-content\">\r\n        <div class=\"acf-innerblocks-container\">\r\n                        \r\n            <div class=\"tab-link\"  id=\"tab-link-downloads-822\" >\r\n                <a href=\"#tab-body-downloads-822\"  data-id=\"822\">\r\n                    Downloads                <\/a>\r\n            <\/div>\r\n            \r\n\r\n                        <div class=\"tab-body  bloque-noticias bloque-tabs-resources-downloads\" id=\"tab-body-downloads-822\" >\r\n            <div  class=\"row\">                        <article class=\"col-xl-4 col-md-6 col-12\">\r\n                        <div class=\" row bl-texto\">\r\n                            <div class=\"bl-datos col-md-3 col-3\"> \r\n                                                                <img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/LABEL-312-CentoBiome-Flyer-V1.0_Web-4-pdf-283x400.jpg\" alt=\"CentoBiome | Product Sheet\" class=\"file-thumbnail\">\r\n                                                            <\/div>\r\n                            <div class=\" col-md-9 col-9\">       \r\n\r\n                                <h4 class=\"bl-titulo\">CentoBiome | Product Sheet<\/h4>\r\n                                \r\n                                <div class=\"bl-description\">\r\n                                Minimally Invasive Endometrial Microbiome Test                                <\/div>\r\n                                \r\n                                <div class=\"bl-links\">\r\n                                                                    <a href=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2026\/10\/LABEL-312-CentoBiome-Flyer-V1.0_Web-4.pdf\" target=\"_blank\" class=\"btn btn-2\">Download<\/a>\r\n                                \r\n                                <\/div>\r\n                            <\/div>\r\n\r\n                        <\/div>\r\n                    <\/article>\r\n                                                        \r\n                \r\n                <\/div>                          \r\n            <\/div>\r\n            \r\n\r\n\r\n\r\n                        <div class=\"tab-link\"  id=\"tab-link-webinars-822\" >\r\n                <a href=\"#tab-body-webinars-822\"  data-id=\"822\">\r\n                    Webinars                <\/a>\r\n            <\/div>      \r\n\r\n            <div class=\"tab-body bloque-noticias\" id=\"tab-body-webinars-822\" >\r\n                <div  class=\"row\">                        <article class=\"col-xl-4 col-md-6 col-12\">\r\n                            <div class=\"item-noticia    \">\r\n\r\n                                <div class=\"bl-texto\">            \r\n                                    <a href=\"https:\/\/www.centogene.com\/pl\/webinar\/%e7%94%9f%e6%ae%96%e5%81%a5%e5%ba%b7%e4%b8%8e%e7%94%a2%e5%89%8d%e9%81%ba%e5%82%b3%e5%ad%a6%e6%aa%a2%e6%b8%ac\/\" rel=\"bookmark\" title=\"\u751f\u6b96\u5065\u5eb7\u4e0e\u7522\u524d\u907a\u50b3\u5b66\u6aa2\u6e2c\" class=\"bl-enlace\">\r\n                                    <h4 class=\"bl-titulo\">\u751f\u6b96\u5065\u5eb7\u4e0e\u7522\u524d\u907a\u50b3\u5b66\u6aa2\u6e2c<\/h4>\r\n                                    <\/a>\r\n                                    \u7814\u8a0e\u6703\u4e2d\uff0c\u6211\u5011\u8ad6\u8ff0\u4e86 CENTOGENE \u7522\u524d\u7be9\u67e5\u9078\u9805\uff0c\u4ee5\u53ca\u7522\u524d\u6aa2\u6e2c\u5982\u4f55\u5728\u5b55\u9031\u671f\u6642\u767c\u63ee\u95dc\u9375\u4f5c\u7528\uff0c\u5feb\u901f\u5c0b\u627e\u7b54\u6848\u3002                                    <div class=\"bl-fecha\">\r\n                                     <time class=\"updated\" datetime=\"2021-06-1\" pubdate>01 cze, 2021<\/time>                                     <\/div>\r\n                                    <div class=\"bl-topics\"><a href=\"https:\/\/www.centogene.com\/pl\/topic\/reproductive-health\/\" class=\"cat-link\">Reproductive Health<\/a><\/div>  \r\n                                    <a href=\"https:\/\/www.centogene.com\/pl\/webinar\/%e7%94%9f%e6%ae%96%e5%81%a5%e5%ba%b7%e4%b8%8e%e7%94%a2%e5%89%8d%e9%81%ba%e5%82%b3%e5%ad%a6%e6%aa%a2%e6%b8%ac\/\" rel=\"bookmark\" title=\"\u751f\u6b96\u5065\u5eb7\u4e0e\u7522\u524d\u907a\u50b3\u5b66\u6aa2\u6e2c\" class=\"btn btn-2\">Watch now<\/a>\r\n\r\n                                <\/div>\r\n                            <\/div>\r\n                        <\/article>\r\n                                            <article class=\"col-xl-4 col-md-6 col-12\">\r\n                            <div class=\"item-noticia    \">\r\n\r\n                                <div class=\"bl-texto\">            \r\n                                    <a href=\"https:\/\/www.centogene.com\/pl\/webinar\/reproductive-health-and-prenatal-genetic-testing\/\" rel=\"bookmark\" title=\"Reproductive Health and Prenatal Genetic Testing\" class=\"bl-enlace\">\r\n                                    <h4 class=\"bl-titulo\">Reproductive Health and Prenatal Genetic Testing<\/h4>\r\n                                    <\/a>\r\n                                    Throughout the CentoTalk, Clarice Loh provides a detailed overview of CENTOGENE\u2019s prenatal screening options and how prenatal testing plays an essential role in facilitating early answers when they\u2019re needed most.                                    <div class=\"bl-fecha\">\r\n                                     <time class=\"updated\" datetime=\"2021-04-19\" pubdate>19 kwi, 2021<\/time>                                     <\/div>\r\n                                    <div class=\"bl-topics\"><a href=\"https:\/\/www.centogene.com\/pl\/topic\/reproductive-health\/\" class=\"cat-link\">Reproductive Health<\/a><\/div>  \r\n                                    <a href=\"https:\/\/www.centogene.com\/pl\/webinar\/reproductive-health-and-prenatal-genetic-testing\/\" rel=\"bookmark\" title=\"Reproductive Health and Prenatal Genetic Testing\" class=\"btn btn-2\">Watch now<\/a>\r\n\r\n                                <\/div>\r\n                            <\/div>\r\n                        <\/article>\r\n                                    \r\n                    <div class=\"text-center\">\r\n                                            <a href=\"\/resources\/webinars\/?topic=wes#webinarsblock\" class=\"btn btn-primary\">See more webinars<\/a>                        \r\n                                        <\/div>\r\n\r\n                <\/div>                   \r\n\r\n            <\/div>\r\n            \r\n\r\n\r\n                        <div class=\"tab-link\"  id=\"tab-link-publications-822\" >\r\n                <a href=\"#tab-body-publications-822\"  data-id=\"822\">\r\n                    Scientific Publications                <\/a>\r\n            <\/div>\r\n\r\n           \r\n            <div class=\"tab-body bloque-noticias\" id=\"tab-body-publications-822\" >\r\n                <div  class=\"row\">                            <article class=\" col-xl-4 col-md-6 col-12\">\r\n                                <div class=\" item-noticia \">\r\n                                    <div class=\"bl-texto \">       \r\n                \r\n                                    <h4 class=\"bl-titulo\">Proof-of-Principle Rapid Noninvasive Prenatal Diagnosis of Autosomal Recessive Founder Mutations<\/h4>\r\n                                    <p><strong>Ten parental alleles in eight unrelated fetuses were diagnosed successfully based on the noninvasive method developed in this study. Read more!<\/strong><\/p>\r\n                                                                        \r\n                                   \r\n\r\n                                                                            <div class=\"bl-autores\">\r\n                                        Author(s):   Rolfs, Prof. Arndt, MD, Zeevi, David, Altarescu, Prof. Gheona, MD, Zahdeh, Fouad, PhD, Weinberg-Shukron, Ariella, Dinur, Tama, PhD, Chicco, Gaya, Herskovitz, Yair, Renbaum, Paul, Elstein, Deborah, Levy-Lahad, Ephrat, MD, Zimran, Ari, MD                                        <\/div>\r\n                                                                        <div class=\"bl-fecha\">\r\n                                         <time class=\"updated\" datetime=\"2015-09-30\" pubdate>30 wrz, 2015<\/time>                                     <\/div>\r\n                                    <div class=\"bl-topics\"><a href=\"https:\/\/www.centogene.com\/pl\/topic\/metabolic-disorders\/\" class=\"cat-link\">Metabolic Disorders<\/a><a href=\"https:\/\/www.centogene.com\/pl\/topic\/reproductive-health\/\" class=\"cat-link\">Reproductive Health<\/a><\/div>  \r\n                                                    \r\n                                        <a href=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/Publication_Proof-of-principle_rapid_noninvasive_prenatal_diagnosis_of_autosomal_recessive_founder_mutations.pdf\" rel=\"bookmark\" title=\"Proof-of-Principle Rapid Noninvasive Prenatal Diagnosis of Autosomal Recessive Founder Mutations\" class=\"btn btn-2\" target=\"_self\">Read publication (PDF)<\/a>\r\n                                                                        <\/div>\r\n                                <\/div>\r\n                            <\/article>\r\n                                                <article class=\" col-xl-4 col-md-6 col-12\">\r\n                                <div class=\" item-noticia \">\r\n                                    <div class=\"bl-texto \">       \r\n                \r\n                                    <h4 class=\"bl-titulo\">Validation of a Semiconductor Next-Generation Sequencing Assay for the Clinical Genetic Screening of CFTR<\/h4>\r\n                                    <p><strong>We have explored a more efficient genetic screening strategy based on next-generation sequencing (NGS) of the CFTR gene. Read more!<\/strong><\/p>\r\n                                                                        \r\n                                   \r\n\r\n                                                                            <div class=\"bl-autores\">\r\n                                        Author(s):   Rolfs, Prof. Arndt, MD, Trujillano, Daniel, PhD, Kandaswamy, Krishna Kumar, PhD, Eichler, Sabrina, PhD, Creed Geraghty, Jenny, Weiss, Maximilian E. R., K\u00f6ster, Julia, Papachristos, Efstathios B., Werber, Martin, Marais, Anett, Baysal, Erol, MD, Jaber, Iqbal Yousuf, Mehaney, Dina, MD, Farra, Chantal, MD                                        <\/div>\r\n                                                                        <div class=\"bl-fecha\">\r\n                                         <time class=\"updated\" datetime=\"2015-03-23\" pubdate>23 mar, 2015<\/time>                                     <\/div>\r\n                                    <div class=\"bl-topics\"><a href=\"https:\/\/www.centogene.com\/pl\/topic\/metabolic-disorders\/\" class=\"cat-link\">Metabolic Disorders<\/a><a href=\"https:\/\/www.centogene.com\/pl\/topic\/ngs\/\" class=\"cat-link\">NGS<\/a><a href=\"https:\/\/www.centogene.com\/pl\/topic\/reproductive-health\/\" class=\"cat-link\">Reproductive Health<\/a><\/div>  \r\n                                                    \r\n                                        <a href=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/Publication_Trujillano_et_al-2015-Molecular_Genetics_Genomic_Medicine.pdf\" rel=\"bookmark\" title=\"Validation of a Semiconductor Next-Generation Sequencing Assay for the Clinical Genetic Screening of CFTR\" class=\"btn btn-2\" target=\"_self\">Read publication (PDF)<\/a>\r\n                                                                        <\/div>\r\n                                <\/div>\r\n                            <\/article>\r\n                                                <article class=\" col-xl-4 col-md-6 col-12\">\r\n                                <div class=\" item-noticia \">\r\n                                    <div class=\"bl-texto \">       \r\n                \r\n                                    <h4 class=\"bl-titulo\">A Novel Mutation Causing 17-\u03b2-Hydroxysteroid<\/h4>\r\n                                    <p><strong>This is the first case report in Oman and the Gulf region of a 17-\u03b2-hydroxysteroid dehydrogenase type 3 (17-\u03b2-HSD3) deficiency with a novel mutation in the HSD17B3 gene that has not been previously described in the medical literature.<\/strong><\/p>\r\n                                                                        \r\n                                   \r\n\r\n                                                                            <div class=\"bl-autores\">\r\n                                        Author(s):   Al-Sinani, Aisha                                        <\/div>\r\n                                                                        <div class=\"bl-fecha\">\r\n                                         <time class=\"updated\" datetime=\"2015-02-28\" pubdate>28 lut, 2015<\/time>                                     <\/div>\r\n                                    <div class=\"bl-topics\"><a href=\"https:\/\/www.centogene.com\/pl\/topic\/reproductive-health\/\" class=\"cat-link\">Reproductive Health<\/a><\/div>  \r\n                                                    \r\n                                        <a href=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/Publication_Aisha_Al-Sinani_A_Novel_Mutation_Causing_17-b-Hydroxysteroid.pdf\" rel=\"bookmark\" title=\"A Novel Mutation Causing 17-\u03b2-Hydroxysteroid\" class=\"btn btn-2\" target=\"_self\">Read publication (PDF)<\/a>\r\n                                                                        <\/div>\r\n                                <\/div>\r\n                            <\/article>\r\n                                         <div class=\"text-center\">\r\n                                            <a href=\"\/resources\/scientific-publications\/?topic=wes#publicationsblock\" class=\"btn btn-primary\">See more publications<\/a>                        \r\n                                        <\/div>\r\n                <\/div>                  \r\n\r\n            <\/div>\r\n                    <\/div>\r\n    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class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":2037,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-11101","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CentoBiome | CENTOGENE<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.centogene.com\/pl\/zdrowie-reprodukcyjne\/centobiom\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CentoBiome | CENTOGENE\" \/>\n<meta property=\"og:url\" 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