CENTOGENE works alongside academic and industrial partners, as well as patient organizations, to develop new diagnostic assays and biomarkers that can help to diagnose and monitor diseases.

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  1. Biomarker Discovery

Diagnosis, Prediction and Therapy Monitoring

Our biomarker portfolio enables you to diagnose initially and monitor constantly with adherence to

  • Realistic reflection of the burden of the disease
  • Solid basis to reflect therapeutic measures
  • Link to clinical manifestation
  • Easy and reliable quantification

CENTOGENE’s biomarkers

  • Easy analysis using DBS (dried blood spots) technology
  • Linked to clinical manifestation
  • Quantify easily and reliably in clinical samples
  • Reflect realistically the burden of the disease
  • Elucidate the molecular pathogenesis of the disease
  • Reflect the therapeutic measure outcomes

Novel tandem mass spectrometry (MRM-MS)

  • Proven expertise in the identification of new biomarkers, validated in epidemiological clinical trials
  • Established tandem mass spectrometry (MRM-MS) based biomarker tests for Gaucher, Niemann-Pick type C, Fabry and Farber disease
  • Optimized and facilitated sample logistics with our CE-labeled filtercards, CentoCard®

Application of CENTOGENE’s CE-labeled biomarkers

CentoGaucher, CentoFabry, CentoFarber and CentoNPC are the first CE-labeled test methods for exact measuring of the biomarker in Gaucher, Fabry, Farber disease as well as Niemann-Pick disease type C. They are developed as easy and fast screening techniques for measuring the biomarker levels in affected patients based on tandem mass spectrometry (MRM-MS).

Scientific articles

Selected biomarker level

Lyso-Gb1 levels in Gaucher patients, Gaucher carriers and healthy controls

Lyso-Gb1 is specifically increased in Gaucher patients compared with healthy controls. The affected Gaucher patients can be clearly distinguished from the Gaucher carrier cohort and healthy control cohort.

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