Single-variant-specific, single-gene-specific and panel diagnostics for somatic mutations in tumors

CENTOGENE's somatic mutation tests are highly sensitive, easy to use, and accurate for identifying even low frequency variants successfully.

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  1. Single-Gene-Specific Somatic Mutation Testing

Somatic mutation testing

Molecular profiling is critical for identifying and characterizing unique somatic variants that accumulate in cancer cells. We offer analytical tests for somatic variants in tumor tissue that can help to identify diagnostic, prognostic or predictive biomarkers.

Next-generation sequencing is becoming more widely adopted as a valuable method for somatic mutation analysis in cancer. CENTOGENE offers hotspot targeted mutation analysis, selective sequencing of gene regions, full gene sequencing and panel testing for the analysis of dozens of cancer-related genes in parallel.

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Downloads for somatic mutations testing

Overview of single gene tests for somatic mutations

Gene test Associated cancer types Test methods availableHow to order

BRAF

xnon-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small-cell lung carcinoma, and lung adenocarcinoma

a. Hot spot targeted mutation testing

b. Selective sequencing of exon 15

c. Full gene sequencing

d. Panel testing

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CALR

Myeloproliferative neoplasms, including myelofibrosis, essential thrombocythemia

a. Selective sequencing of exon 9

b. Panel testing

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EGFR Non-small-cell lung cancer

a. Hotspot targeted mutation testing

b. Exons 18-21 testing

c. Panel testing

 

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IDH1 Lower grade diffuse gliomas (grade II–III), secondary glioblastomas, diagnosed glioblastomas, acute myeloid leukemia (AML), central nervous cancer

a. Selective sequencing of exon 4

b. Full gene testing

c. Panel testing

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IDH2 Acute myeloid leukemia (AML), gliomas

a. Selective sequencing of exon 4

b. Full gene sequencing

c. Panel testing

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JAK2 Acute lymphoblastic leukemia (ALL), polycythemia vera, thrombocythemia and idiopathic myelofibrosis 

a. Selective sequencing of exons 12,14 and 16

b. Full gene testing

c. Panel testing

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KIT Gastrointestinal stromal tumors (GISTs), acute myeloid leukemia (AML)

a. Selective sequencing of exons 8,9,11,13 and 17

b. Full gene sequencing

c. Panel testing

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KRAS Colorectal cancer

a. Hotspot targeted mutation testing

b. Full gene testing

c. Panel testing

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NRAS Colorectal cancer

a. Hotspot targeted mutation testing

b. Full gene testing

c. Panel testing

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Our portfolio for somatic mutation testing

Panels

Single Gene Analysis

Latest scientific articles on somatic mutations

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