Somatic mutation testing

Testing for the presence of cancer requires the utmost personal care and consideration

Somatic mutation testing is enormously beneficial for improving the prognosis and the quality of life of cancer-affected patients. Our team of hereditary and somatic cancer experts will support you at every step of the process.

  1. Somatic Mutations for Oncogenetics

Identifying somatic mutations for tumor profiling

Every cancer cell has its own pattern of mutated genes. This results in each cancer case, and even parts of the tumor, to be individual with respect to diagnosis, prognosis and treatment response.

The presence of recurrent somatic mutations allows us to create a detailed molecular fingerprinting of the tumor and to identify important diagnostic tumor subtypes.

What do we know about somatic mutations?

Cancer is one of the leading causes of morbidity and mortality worldwide. Cancer can be the result of a genetic predisposition that is inherited from family members (germline (hereditary) gene mutation) or it can be the result of the acquired mutations accumulated during a lifetime (somatic (acquired) mutation). Most cancers are is independent of a germline (hereditary) mutation.

Unlike regular cells, cancer cells do not experience physiological elimination of “programmed cell death” or “apoptosis”; instead they continue to grow and divide. Tumor cells show uncontrolled proliferation if there are mutations in the genes involved in cell division .

How can somatic genetic testing help patient care?

Somatic mutation analysis is a standard of practice for tumors in order to identify therapeutic sensitizing and resistance mutations. This allows a finer assessment of the diagnosis and prognosis and targeted therapies directed towards the individual patients tumor profile.

Why choose CENTOGENE?

Excellent analysis using the most advanced NGS technology

CAP and CLIA and ISO certification and accreditation

Medical expertise in the interpretation of complicated cases

Affordable prices and shortest turnaround times

Highest level of quality/accuracy

Diagnostic services for somatic mutations

Covers the 63 most important genes and more than 1,000 mutations associated with solid tumors.

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Targets the 2,800 most common cancer-causing mutations in the 49 most common cancer-causing genes.

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Covers 54 of the most important genes and more than 1,000 mutations associated with myeloid tumor.

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Multiple screening tests for targeted and general screening of mutations in several cancer-related genes.

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Methodological summary of CENTOGENE’s somatic mutation testing

  • Panel: Bi-directional NGS sequencing for all genes included in the panels (listed here below)
    Single gene: Bi-directional sequencing for somatic mutations associated for this gene
  • Panel: NGS panel analysis with complete 100% coverage for the target regions (technical accuracy of <98.1%)
    Single gene: Sequencing is with 96.5% coverage for the target regions (technical accuracy of <98.1%)
  • For every panel gene and full gene analysis, the complete coding sequence, exon/intron boundaries 10 bp into the intron, relevant promoter gene regions and all HGMD described pathogenic variants are analyzed, with subsequent variant validation for any clinically relevant genetic variant detected.

Our medical and genetic experts can help determine which genetic testing is right to analyze the risk for hereditary cancer syndromes. After testing, result evaluation and specific recommendations for each individual case are necessary to decide on further steps for full patient care.

Downloads for somatic mutation testing

  • One pager - Acute myeloid leukemia tumor panel

  • One pager - BRCA1/ BRCA2 somatic mutation analysis

  • One pager - Colorectal cancer solid tumor panel

  • One pager - Lung cancer solid tumor panel


Our portfolio for somatic mutation testing

Single Gene Analysis

Latest scientific articles

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    Looking for a one-stop-solution for your laboratory? Join this webinar to learn more about our CentoCloud® for diagnostic NGS panels, clinical bioinformatics & medical interpretation in the oncogenetic workflow.

  • Gastric cancer

    Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant susceptibility for diffuse gastric cancer, a poorly differentiated adenocarcinoma localized in the stomach wall. Gastric cancer is one of the most common cancers in the world, with the highest incidence rates in Japan (80 cases per 100,000) and eastern Asia.

  • Ovarian cancer

    Ovarian cancer is the most lethal of all gynecological cancers, and the annual incidence of ovarian cancer is 12.1 per 100,000 women. Familial ovarian carcinoma has been described in the context of hereditary breast and ovarian cancer (HBOC) syndrome. Inherited in an autosomal dominant fashion, HBOC is characterized by an increased risk for female and male breast cancer, ovarian cancer and other cancers. Known genetic causes of HBOC have largely been explained by germline pathogenic variants in the BRCA1 and BRCA2 genes.

CentoCard® – simplify your logistics

Sending patients´ samples as easy as mailing a postcard.

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CentoPortal® – online ordering portal

Manage your genetic testing online supported by CentoCard®.

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Get in touch with our Department of Medical Quality and Counseling

Please call or send us an email with any questions and benefit from our medical consultation services, available both before and after testing.

+49 - 381 - 203 - 652 - 222 

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