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CentoNIPT® offers genetic, non-invasive prenatal testing (NIPT) to screen for the most common fetal chromosomal abnormalities. Our test combines the latest next generation sequencing technology with expert medical reporting.

CentoNIPT® - Non invasive prenatal testing at CENTOGENE

Conventional prenatal testing for fetal chromosomal abnormality involves either chorionic villus sampling or amniocentesis. Although these procedures are highly invasive and carry an increased risk of miscarriage, they have become standard practice worldwide due to their high levels of accuracy and range of abnormalities detected.

Modern genetic testing provides unparalleled accuracy and detection against other non invasive testing methods - ultrasonography or nuchal translucency testing.

CentoNIPT® is performed on a single draw of maternal blood, and is therefore minimally invasive and completely safe. The test combines the latest next-generation sequencing technology with the highest quality medical reporting.

Our medical expertise and experience makes us ideally suited to provide you and your patients with reliable, well supported result interpretation.

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Fetal chromosomal abnormalities

  • Approximately 1% of all babies will be born with with a chromosomal abnormality, which can cause physical disability and mental retardation
  • 70% of syndromic congenital abnormalities are contributed by Trisomy T21, T18 or T13 and 10% by Turner syndrome (Monosomy X)
  • The risk of trisomy increases significantly with maternal age

  Sensitivity Specificity
Trisomies
Trisomy 21 (Down syndrome) 99,14% 99,94%
Trisomy 18 (Edwards syndrome) 98,31% 99,90%
Trisomy 13 (Patau syndrome) 98,15% 99,95%
Sex chromosome aneulpoidies & fetal gender
Monosomy X (Turner syndrome) 95,0% 99,0%
XXX (Triple X) ? ?
XXY (Klinefelter syndrome) ? ?
XYY (Jacobs syndrome) ? ?

Why choose CENTOGENE?


 
100% safe for mother & child
Only 9ml of blood from the mother required

 
Fast & reliable results
Results within five working days

 
Test as early as possible
As early as 10 gestational weeks

 
Maximum certainty
Latest next generation sequencing technology and high-quality medical reporting

Your experts in prenatal diagnostics


Fast & accurate results

Our optimized workflows provide a full medical report within five working days from high-quality, validated results.

High sensitivity & specificity

CentoNIPT® uses the latest nextgeneration sequencing technology. Confirmation of the fetal fraction is included in each analysis to ensure accurate results.

The CENTOGENE advantage

The combination of the latest next-generation sequencing technology with high-quality medical reporting delivers risk-free testing of the developing child with the greatest accuracy and quality.

Frequently asked questions

NIPT is a non-invasive, cell-free DNA peripheral blood screening created to determine the risk of fetal genetic diseases (most commonly trisomy 21, 18, and 13) in pregnant women of any age. NIPT can be performed as early as 10 gestational weeks, and turnaround time is 3-5-10 working days. The sensitivity and specificity of NIPT test is >99% and a false-positive rate is less than 0.1%.

Other types of prenatal screening and diagnostic tests may require more than one office visit, multiple blood draws, additional interventions such as drawing of amniotic fluid or collection of chorionic villi and they carry a risk of miscarriage.

If the NIPT test results are positive, additional tests could be performed, including amniocentesis, chorionic villi sampling (CVS), and fetal blood analysis. Those “classic” prenatal genetic tests are with certain miscarriage risk but with higher detection possibilities.

A positive NIPT test result indicates a strong suggestion that the foetus is affected by one of the investigated chromosomal/genetic abnormalities such as trisomies 13, 18 and 21. A negative result indicates a very low risk that the foetus is affected by one of the investigated chromosomal/genetic anomalies.

Most sources say that there is no more than a 1% chance of a false positive result and that less than one in 1,000 cases has false negative results.

False positive NIPT results:

  • Placental mosaicism
  • Chromosome variants
  • Vanishing twin
  • Maternal mosaicism due to malignancy (rare)

False negative NIPT results:

  • Low fetal DNA fraction
  • Mosaicism
  • Chromosome variants

A positive NIPT test result indicates a strong suggestion that the foetus is affected by one of the investigated chromosomal/genetic abnormalities such as trisomies 13, 18 and 21. A negative result indicates a very low risk that the foetus is affected by one of the investigated chromosomal/genetic anomalies.

If non-invasive prenatal testing indicates that an abnormality is present that suggests a genetic/chromosomal disease or some other birth defect, further testing will be necessary to confirm this. The next step will most likely be chorionic villus sampling (CVS) and/or, few weeks later, amniocenteses.

Pregnant woman of any age or pregnancy risk with or without family history of genetic/chromosomal condition.

Yes. NIPT test can be used in twin pregnancies and it is possible to differentiate genetic test results obtained from cell-free DNA from different twins.

NIPT test can detect microdeletions with high sensitivity.

NIPT test can be performed at any pregnancy age but the best time is at 9-10 gestational weeks.

How to order CentoNIPT®


Do you already have a CentoNIPT® box?

Order now!


Prepare the sample using your individual CentoNIPT® box


Order your test at CentoPortal® by using the sample number of your CentoNIPT® box


Package and ship the sample in your CentoNIPT® box


Sample processing and results within five days


Download your report at CentoPortal®


Our medical expertise and experience makes us ideally suited to provide you and your patients with reliable, well supported result interpretation.

Request your
CentoNIPT® starter package

What test results should you expect and what are the limitations of the test?

CentoNIPT® screens for chromosome aneuploidies (chromosomes 21, 18, and 13, X and Y) and is validated for single and twin pregnancies from the 10th gestational week. Although CentoNIPT® is highly effective for detecting the majority of fetal chromosomal abnormalities, a pregnancy may still be associated with other chromosomal abnormalities, birth defects or complications.

Downloads for CentoNIPT®

  • Whole exome sequencing - Patient information

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CentoPortal® – online ordering portal

Manage your genetic testing online supported by CentoCard®. From online ordering and sample submission through to receipt of the final medical report, CentoPortal® is designed to save time and reduce overall workload.

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Get in touch with our Department of Medical Quality and Counseling

Please call or send us an email with any questions and benefit from our medical consultation services, available both before and after testing.


+49 - 381 - 203 - 652 - 222 

Mon. – Fri. 7 a.m.– 8 p.m. CET • Sat. – Sun. 9 a.m – 5 p.m. CET

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