Cut to the chase

Exhaustive clinical information at a moderate price

Targeting genes associated with all known clinical phenotypes - Get high diagnostic accuracy with the fastest workflow

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  1. Clinical Exome Sequencing

Clinical exome sequencing

CentoDx Plus™ is our largest NGS panel available, covering over 3,200 diseases in the shortest turnaround time.

CentoDx Plus™ focuses on the coding part of all genes associated with known clinical phenotypes, thereby comprising the complete clinical exome. It reduces additional costs and prevents unclear results from sequencing genic regions not related to human diseases.

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Why choose CentoDx Plus™?

Covers ~6,700 clinically relevant genes with known associated phenotypes

Needs only 1 μg of DNA

Turnaround time of <30 business days

Sanger confirmation of all reported variants and comprehensive clinical report

Highlights of CentoDx Plus™

CentoDx Plus™ is a clinical exome product that includes ~6,700 clinically relevant genes with known associated clinical phenotypes. This screening method uses boosted probes over these specific genes, which provides a more uniform and robust coverage and performance over genes of clinical interest as compared to whole exome sequencing. Around 4,000 genes within this panel have ~100% coverage in coding regions.

CentoDx Plus™ focuses on genes listed in OMIM and HGMD where a clear genotype phenotype correlation has been previously demonstrated.

Disorders covered with CentoDx Plus™

  • Metabolic
  • Neurological
  • Reproductive
  • Malformative
  • Ophthalmological
  • Oncogenetic
  • Bone, skin & immunological
  • Cardiovascular
  • Ear, nose & throat
  • Nephrological
  • Hematological
  • Vascular
  • Endocrine
  • Gastrointestinal
  • Muscoloskeletal

High diagnostic accuracy with the fastest workflow

Whole vs. clinical exome sequencing

CENTOGENE products Genes Coverage Information content Likelihood of detecting a specific mutation
Whole exome sequencing - CentoXome® ~20,000 ~97% >10x ~60MB ~93.2%
Clinical exome sequencing - CentoDx Plus™ ~6,700 ~95% >20x ~15MB ~94.1%

Downloads for CentoDx Plus™

  • CentoDx Plus™ - Diagnostic sample report


Get in touch with our Department of Medical Quality and Counseling

Our consultation service is available in several languages.

+49 (0) 381 - 80113 416

Mon. – Fri. 7 a.m.– 8 p.m. CET • Sat. – Sun. 9 a.m – 5 p.m. CET

For our US customers:

+1 (781) 270 1519

Mon. – Fri. 9 a.m. – 5.30 p.m. EST