Clinical exome sequencing
CentoDx Plus™ is our largest NGS panel available, covering over 3,200 diseases in the shortest turnaround time.
CentoDx Plus™ focuses on the coding part of all genes associated with known clinical phenotypes, thereby comprising the complete clinical exome. It reduces additional costs and prevents unclear results from sequencing genic regions not related to human diseases.
Why choose CentoDx Plus™?
Highlights of CentoDx Plus™
CentoDx Plus™ is a clinical exome product that includes ~6,700 clinically relevant genes with known associated clinical phenotypes. This screening method uses boosted probes over these specific genes, which provides a more uniform and robust coverage and performance over genes of clinical interest as compared to whole exome sequencing. Around 4,000 genes within this panel have ~100% coverage in coding regions.
CentoDx Plus™ focuses on genes listed in OMIM and HGMD where a clear genotype phenotype correlation has been previously demonstrated.
- Bone, skin & immunological
- Ear, nose & throat
High diagnostic accuracy with the fastest workflow
Whole vs. clinical exome sequencing
|CENTOGENE products||Genes||Coverage||Information content||Likelihood of detecting a specific mutation|
|Whole exome sequencing - CentoXome®||~20,000||~97% >10x||~60MB||~93.2%|
|Clinical exome sequencing - CentoDx Plus™||~6,700||~95% >20x||~15MB||~94.1%|