CentoICU™ – because life begins today

Genetic testing when every moment counts

For the earliest and fastest diagnosis of critically ill newborns and children under 24 months in intensive care units (ICU).

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  1. Genetic Testing of Newborns

CentoICU™ – the comprehensive NGS panel

CentoICU™ is designed to diagnose genetic conditions that become present in the newborn or early childhood period. Many of these have overlapping phenotypes and diagnosis may have immediate implications for the treatment of newborns and children.

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What is CentoICU™?

Newborns and children under 24 months presenting with life-threatening conditions need a fast and precise diagnosis to ensure rapid and efficient further diagnostic and therapeutic initiation.

Up to one-third of all babies and children admitted to the ICU have a genetic disease. For many of them early identification can make the difference for their immediate and later health.

CentoICU™ is a comprehensive NGS panel that includes 808 genes, explicitly selected for the genetic testing of critically ill newborns and children under 24 months. It is designed to address multiple genetic conditions that may present in the newborn or first childhood period, many with overlapping phenotypes and immediate implications for treatment initiation. It allows clinicians to utilize just one single test to provide an accurate diagnosis of 808 genes and newborn-related diseases using dried blood spots.

Downloads for CentoICU™

When to recommend CentoICU™?

CentoICU™ allows clinicians to utilize one test to provide an accurate assessment for 808 newborn-related genes and associated genetic diseases using dried blood spots, and it provides fast delivery of the results in less than seven (15) days.

CentoICU™ is indicated for newborns and children under 24 months admitted to the ICU and presenting with unclear symptomatology which can be part of a genetic condition, i.e.

  • Bleeding dyathesis
  • Blood abnormalities (anemia)
  • Bone fragility
  • Failure to thrive
  • Heart abnormality/arrhythmia
  • Hepatospenomegaly
  • Hypotonia
  • Ichthyosis/epidermolysis bullosa
  • Metabolic abnormalities*
  • Microcephaly
  • Neutropenia
  • Abnormal newborn screening results**
  • Respiratory failure
  • Skeletal abnormalities/craniosynostosis
  • Skin fragility
  • Unclear seizures

*) Abnormal acylcarnitine profile, amino acidemia/urea, hyperbilirubinemia, hyper-/hypoinsulinism, persistent hypoglycemia, organic acidemia/urea
**) CentoICU™ includes genes to cover all ACMG core panel phenotypes for newborn screening except hearing loss

Why choose CENTOGENE?

Low sample requirements (just 0.5 ml blood, 1 µg DNA or 1 filter card)

Screening of 808 genes and more than 100 associated conditions

Shortest turnaround times – Less than seven days possible

World-class medical reports interpreted by expert human geneticists

What are the advantages of CentoICU™?

  • Two options for delivery of results are available, with the shortest possible turnaround time:

  • CentoICU™ screens 808 genes for abnormalities which allows a definite diagnosis of even very rare diseases
  • Treatment and prognosis defining diagnosis for critical and rare conditions
  • Co-analysis of copy number variations possible using package with CENTOGENE’s CGH array CentoArrayCyto®

Every moment counts

Earlier detection can result in less invasive and lower cost treatments for patients. It can also greatly impact the quality of a child's life.

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Latest scientific articles

What genes are included in CentoICU™?

CentoICU™ is designed for analysis of 808 genes and more than 100 associated conditions/phenotypes. The list of included genes was developed by our expert medical team based on several selection criteria, i.e.:

  • Early onset
  • Severe disease
  • ICU related symptomatology
  • Diseases/syndromes of differential diagnostic value

We will be happy to provide detailed information on the genes within CentoICU™ panel related to a specific set of HPO terms on request.

The following table indicates the distribution of genes depending on HPO terms in 14 categories:

Category Number of genes+ % of genes+
Newborn screening ++ 25 3,1
Metabolism 537 66,6
Skeletal and malformation 498 61,8
Blood disorders 246 30,5
Immunodeficiencies 290 36,0
Lung diseases 342 42,4
Cardiologic disorders 351 43,5
Kidney diseases 174 21,6
Liver diseases 241 29,9
Gastrointestinal disorders 191 23,7
Skin diseases 55 6,8
Neurologic disorders 647 80,3
Muscular disorders 142 17,6
Endocrinology 166 20,6

+) Due to overlapping phenotypes, particular genes are listed in more than one category.
++) Covering all core panel phenotypes as recommended by ACMG for newborn screening except hearing loss.

Get in touch with our Department of Medical Quality and Counseling

Our consultation service is available in several languages.

+49 (0) 381 - 80113 416

Mon. – Fri. 7 a.m.– 8 p.m. CET • Sat. – Sun. 9 a.m – 5 p.m. CET

For our US customers:

+1 (781) 270 1519

Mon. – Fri. 9 a.m. – 5.30 p.m. EST