Tarjeta CentoCard\u00ae<\/a>, su kit patentado y validado de recolecci\u00f3n de muestras de sangre seca, para identificar pacientes con EP con una mutaci\u00f3n en el gen LRRK2 para su reclutamiento en los ensayos cl\u00ednicos de Denali.<\/p>\nLas mutaciones en el gen LRRK2 son una de las causas gen\u00e9ticas m\u00e1s conocidas de la enfermedad de Parkinson y un factor desencadenante de la disfunci\u00f3n lisosomal, que contribuye a la formaci\u00f3n de agregados de prote\u00ednas de cuerpos de Lewy y a la neurodegeneraci\u00f3n.<\/p>\n
\u201cNuestra colaboraci\u00f3n exclusiva subraya la s\u00f3lida capacidad de CENTOGENE para acelerar la identificaci\u00f3n temprana de pacientes con enfermedades gen\u00e9ticas raras en todo el mundo. Como l\u00edderes en el an\u00e1lisis gen\u00e9tico de enfermedades raras, creemos que podemos contribuir al desarrollo de medicamentos modificadores de la enfermedad de Denali para pacientes con enfermedad de Parkinson. CENTOGENE ayudar\u00e1 a Denali a acelerar la inscripci\u00f3n de pacientes en estudios cl\u00ednicos para su programa LRRK2, afirm\u00f3 el Dr. Arndt Rolfs, director ejecutivo y fundador de CENTOGENE.<\/p>\n
\u201cDenali es la primera compa\u00f1\u00eda en realizar ensayos cl\u00ednicos con inhibidores de LRRK2 para el tratamiento de la enfermedad de Parkinson. Esta colaboraci\u00f3n con CENTOGENE es fundamental en nuestros esfuerzos globales para identificar y reclutar pacientes con EP con una mutaci\u00f3n en el gen LRRK2 en nuestros estudios cl\u00ednicos planificados\u201d, declar\u00f3 Carole Ho, MD, Directora M\u00e9dica y Jefa de Desarrollo de Denali. \u201cEstamos impresionados con el enfoque y la tecnolog\u00eda de CENTOGENE y creemos que nuestros esfuerzos conjuntos acelerar\u00e1n la inclusi\u00f3n de pacientes con EP y la finalizaci\u00f3n de nuestros ensayos cl\u00ednicos\u201d.\u201d<\/p>","protected":false},"excerpt":{"rendered":"
CENTOGENE y Denali Therapeutics (NASDAQ: DNLI) anunciaron hoy una colaboraci\u00f3n estrat\u00e9gica para la identificaci\u00f3n y el reclutamiento global de pacientes con enfermedad de Parkinson (EP) LRRK2-positivos.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2402","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"\n
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