{"id":1421,"date":"2025-03-14T11:58:21","date_gmt":"2025-03-14T11:58:21","guid":{"rendered":"http:\/\/centogene.vl22350.dinaserver.com\/?page_id=1421"},"modified":"2025-08-01T14:26:15","modified_gmt":"2025-08-01T14:26:15","slug":"biomarcador-metabolico-de-enzimas","status":"publish","type":"page","link":"https:\/\/www.centogene.com\/es\/diagnostics\/enzymes-metabolic-biomarker\/","title":{"rendered":"Enzimas y biomarcadores metab\u00f3licos"},"content":{"rendered":"<section class=\"bloque-banner-titulo-page  estilo-grey\" id=\"\">\r\n    \r\n    <div class=\"image-wrapper\">\r\n\r\n      <!-- include mp4 video on a loop -->\r\n              <img decoding=\"async\" class=\"\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/csm_centogene-diagnostics-our-tests_biomarker-multiomics-header_6599a09aae.webp\" alt=\"csm_centogene-diagnostics-nuestras-pruebas_biomarcador-multiomics-header_6599a09aae\" \/>\r\n          <\/div>\r\n    <div class=\"container content-wrapper\">\r\n      <div class=\"row justify-content-start align-items-center\">\r\n\r\n\r\n        <div class=\"col-12 col-lg-6 animation fadeTop align-self-center\">\r\n                  <h1>Enzimas y biomarcadores metab\u00f3licos<\/h1>\r\n          <h2 class=\"bl-texto\">Sentando las bases para terapias personalizadas. Combinando informaci\u00f3n de gen\u00f3mica, prote\u00f3mica y metabol\u00f3mica para impulsar el diagn\u00f3stico temprano, la predicci\u00f3n y el seguimiento terap\u00e9utico.<\/h2>           \r\n          <a class=\"btn btn-primary mb-2\" href=\"#more\">M\u00e1s informaci\u00f3n<\/a>\r\n                            <\/div>\r\n\r\n      <\/div>\r\n    <\/div>\r\n\r\n<\/section>\r\n<div class=\"breadcrumbs\">\r\n    <div class=\"container\">\r\n      <div class=\"row\">\r\n        <div class=\"col-12\">\r\n          <ul id=\"breadcrumbs\" class=\"breadcrumbs\"><li><a href=\"https:\/\/www.centogene.com\/es\/\">Inicio<\/a><\/li><\/ul>        <\/div>\r\n      <\/div>\r\n    <\/div>\r\n<\/div>\r\n\r\n\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente-my\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Acelerando los diagn\u00f3sticos y orientando las opciones de tratamiento<\/h2>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">Un biomarcador ideal juega un papel esencial en el diagn\u00f3stico temprano, la predicci\u00f3n y el seguimiento terap\u00e9utico de una enfermedad espec\u00edfica, reflejando la carga de la enfermedad para los pacientes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El uso de un biomarcador, ya sea como herramienta diagn\u00f3stica o en el seguimiento regular de la progresi\u00f3n de la enfermedad, puede ser de gran valor cl\u00ednico para los pacientes. Los biomarcadores pueden utilizarse como medida de la eficacia de la terapia e incluso como gu\u00eda para la dosificaci\u00f3n.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">CENTOGENE ofrece diagn\u00f3stico m\u00e9dico r\u00e1pido de enfermedades hereditarias raras a trav\u00e9s de la cartera m\u00e1s amplia de pruebas gen\u00e9ticas combinada con pruebas de biomarcadores y enzim\u00e1ticas, as\u00ed como la mejor interpretaci\u00f3n de su clase.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocaja tableicons\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h5 class=\"wp-block-heading mb-3\">Las caracter\u00edsticas de los biomarcadores de CENTOGENE<\/h5>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-8f761849 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/centogene_pharma_operationalising_clinical_trials_icon_pharma_single_pill.svg\" alt=\"\" class=\"wp-image-1089\" style=\"object-fit:cover\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Monitoreo de la respuesta al tratamiento<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-8f761849 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene-centocard-icon-complete.svg\" alt=\"\" class=\"wp-image-1989\" style=\"object-fit:cover;width:70px;height:70px\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Log\u00edstica y an\u00e1lisis simplificados en muestras de sangre seca (DBS) con tecnolog\u00eda de tarjeta de filtro con marca CE (CentoCard<sup>\u00ae<\/sup>)<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-8f761849 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene-biomarker-testing-icon-biomarker.svg\" alt=\"\" class=\"wp-image-3389\" style=\"object-fit:cover;width:70px;height:70px\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Alta sensibilidad y especificidad<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-8f761849 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene-chromosomal-microarray-testing-icon-calendar-TAT.svg\" alt=\"\" class=\"wp-image-1572\" style=\"object-fit:cover;width:70px;height:70px\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Tiempo de respuesta corto<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-8f761849 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/Icon_Pharma_Pill_Bottle.svg\" alt=\"\" class=\"wp-image-3388\" style=\"object-fit:cover;width:70px;height:70px\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Orientar un r\u00e9gimen de tratamiento individualizado para obtener mejores resultados<\/p>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocolor\"   id=\"more\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Uso de pruebas bioqu\u00edmicas<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Los ensayos de actividad enzim\u00e1tica y biomarcadores pueden utilizarse para el diagn\u00f3stico de enfermedades y la validaci\u00f3n del desarrollo de nuevos f\u00e1rmacos. Las enzimas y los biomarcadores bioqu\u00edmicos suelen desempe\u00f1ar funciones clave en los procesos fisiol\u00f3gicos. Por lo tanto, constituyen una herramienta eficaz para revelar signos tempranos de enfermedades o para optimizar su progresi\u00f3n.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocaja tableicons\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h4 class=\"wp-block-heading\">Uso general de las pruebas bioqu\u00edmicas<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Orientar reg\u00edmenes terap\u00e9uticos<\/li>\n\n\n\n<li>Pruebas de cohorte en riesgo<\/li>\n<\/ul>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n<\/div>\n<\/div>\n\n\n    <section class=\"bloque-personalizado bloque-cajas-imgs estilo-cajasiconos\" >\n        <div class=\"\"> \n                        <div class=\"row justify-content-between\">\n\n                                        \n                <div class=\"swiper-slide col-12 col-md-3 delay-1 caja\">\n                    <div class=\"caja-inner\" >\n                                                <div class=\"bl-imagen animationNo scalexTop delay-1\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene-biomarker-testing-icon-biomarker.svg\" class=\"\" alt=\"\" \/> <\/div>                                               \n                                                \n                        <div class=\"caja-text\">\n                                                        <h3 class=\"bl-titulo\">ENSAYOS DE BIOMARCADORES Y ENZIMAS<\/h3>\n                            <ul class=\"t3m-List t3m-List--unordered\">\n<li>Monitoreo de seguimiento<\/li>\n<li>Mide la progresi\u00f3n de la enfermedad y la respuesta al tratamiento.<\/li>\n<li>Diagn\u00f3stico diferencial<\/li>\n<\/ul>\n      \n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                            \n                <div class=\"swiper-slide col-12 col-md-3 delay-1 delay-2 caja\">\n                    <div class=\"caja-inner\" >\n                                                <div class=\"bl-imagen animationNo scalexTop delay-2\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene-biomarker-testing-icon-computer-profile.svg\" class=\"\" alt=\"\" \/> <\/div>                                               \n                                                \n                        <div class=\"caja-text\">\n                                                        <h3 class=\"bl-titulo\">Paneles enzim\u00e1ticos<\/h3>\n                            <p>Diagn\u00f3stico de primer paso de enfermedades metab\u00f3licas complejas y multisist\u00e9micas<\/p>\n      \n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                            \n                <div class=\"swiper-slide col-12 col-md-3 delay-1 delay-2 delay-3 caja\">\n                    <div class=\"caja-inner\" >\n                                                <div class=\"bl-imagen animationNo scalexTop delay-3\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene-biomarker-testing-icon-dna-single-genes-2.svg\" class=\"\" alt=\"\" \/> <\/div>                                               \n                                                \n                        <div class=\"caja-text\">\n                                                        <h3 class=\"bl-titulo\">An\u00e1lisis de biomarcadores\/enzimas y genes individuales<\/h3>\n                            <ul class=\"t3m-List t3m-List--unordered\">\n<li>Trastorno espec\u00edfico sospechado<\/li>\n<li>S\u00edntomas claramente definibles<\/li>\n<li>Para una toma de decisiones de tratamiento integral<\/li>\n<\/ul>\n      \n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                            \n                <div class=\"swiper-slide col-12 col-md-3 delay-1 delay-2 delay-3 delay-4 caja\">\n                    <div class=\"caja-inner\" >\n                                                <div class=\"bl-imagen animationNo scalexTop delay-4\"><img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene-biomarker-testing-icon-dna-panels.svg\" class=\"\" alt=\"\" \/> <\/div>                                               \n                                                \n                        <div class=\"caja-text\">\n                                                        <h3 class=\"bl-titulo\">Panel gen\u00e9tico + Biomarcador\/Enzima<\/h3>\n                            <ul class=\"t3m-List t3m-List--unordered\">\n<li>Trastorno metab\u00f3lico sospechado<\/li>\n<li>S\u00edntomas complejos y superpuestos con un amplio diagn\u00f3stico diferencial<\/li>\n<li>Resultados anormales de las pruebas de detecci\u00f3n en reci\u00e9n nacidos<\/li>\n<li>Ingreso a una unidad de cuidados intensivos neonatales<\/li>\n<li>S\u00edntomas relacionados con afecciones neurol\u00f3gicas de etimolog\u00eda desconocida<\/li>\n<li>S\u00edntomas superpuestos con diferente edad de aparici\u00f3n y gravedad<\/li>\n<\/ul>\n      \n                                                                          \n                        <\/div>                        \n                        \n                    <\/div>      \n                <\/div>       \n                \n                                     \n             \n            \n        <\/div>\n    <\/div>  \n<\/section>\n\n\n\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente-my\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Las caracter\u00edsticas de los biomarcadores de CENTOGENE<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>F\u00e1cil de analizar mediante tecnolog\u00eda DBS (gotas de sangre seca)<\/li>\n\n\n\n<li>Vinculado a la manifestaci\u00f3n cl\u00ednica<\/li>\n\n\n\n<li>Cuantifique de forma f\u00e1cil y fiable en muestras cl\u00ednicas<\/li>\n\n\n\n<li>Reflejar de forma realista la carga de la enfermedad<\/li>\n\n\n\n<li>Dilucidar la patog\u00e9nesis molecular de la enfermedad.<\/li>\n\n\n\n<li>Reflejar los resultados de las medidas terap\u00e9uticas<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Estrategias de prueba: r\u00e1pidas y precisas<\/h2>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">En enfermedades y v\u00edas patol\u00f3gicas complejas, una prueba gen\u00e9tica por s\u00ed sola no suele proporcionar la informaci\u00f3n necesaria para un diagn\u00f3stico definitivo. Por ello, <strong>CENTOGENE ha sido pionera en la combinaci\u00f3n de diferentes pruebas<\/strong> , como patrones de biomarcadores y multibiomarcadores, con recomendaciones claras para las estrategias de an\u00e1lisis\u00b9 <sup>.<\/sup> Estas estrategias ofrecen a usted y a sus pacientes una soluci\u00f3n m\u00e1s r\u00e1pida, fiable y completa, proporcionando respuestas vitales y oportunas cuando m\u00e1s se necesitan.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Pruebas<\/th><th>Estrategia<\/th><th>Cartera CENTOGENE<\/th><\/tr><\/thead><tbody><tr><th><strong>Biomarcador<\/strong><\/th><td>Pruebas de biomarcadores para diagn\u00f3stico previo o posterior<\/td><td>para las siguientes enfermedades: enfermedad de Gaucher, enfermedad de Fabry, enfermedad de Niemann-Pick tipo A\/B y tipo C, deficiencia de AADC.<\/td><\/tr><tr><th><strong>Enzima<\/strong><\/th><td>Pruebas de actividad enzim\u00e1tica para diagn\u00f3stico previo o posterior<\/td><td>Para las siguientes enfermedades: enfermedad de Gaucher, enfermedad de Fabry, enfermedad de Pompe, s\u00edndrome de Hurler (MPS I), s\u00edndrome de Hunter (MPS II), s\u00edndrome de Maroteaux-Lamy (MPS VI), s\u00edndrome de Morquio B (MPS IV B), enfermedad de Wolman, s\u00edndrome de Sanfilippo B (MPS III B), beta-manosidosis, fucosidosis, s\u00edndrome de Sly (MPS VII), enfermedad de Tay-Sachs, enfermedad de Sandhoff, enfermedad de Schindler\/Kanzaki, enfermedad de Santavuori-Haltia, enfermedad de Jansky-Bielschowsky.<\/td><\/tr><tr><th colspan=\"3\">Soluciones multi\u00f3micas<\/th><\/tr><tr><th><strong>Panel gen\u00e9tico + biomarcador\/enzima<\/strong><\/th><td>Primero se prueba una amplia gama de genes, seguido de pruebas bioqu\u00edmicas<sup>1<\/sup><\/td><td class=\"translation-block\">CentoMetabolic <sup>\u00ae<\/sup> MOx (~ 200 trastornos metab\u00f3licos)<br> Tambi\u00e9n disponible en combinaci\u00f3n con WES o WGS, y secuenciaci\u00f3n de ARN adicional.<br> Para obtener m\u00e1s informaci\u00f3n, visite: <a href=\"http:\/\/multiomic\" target=\"_self\">Multiomic Solutions<\/a> .<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">La experiencia \u00fanica de CENTOGENE en trastornos metab\u00f3licos<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">TrastornosTransformando la gesti\u00f3n de los trastornos metab\u00f3licos<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Las enfermedades metab\u00f3licas son un grupo de enfermedades hereditarias raras que se caracterizan por la acumulaci\u00f3n anormal de diferentes metabolitos en las c\u00e9lulas, lo que conduce a un funcionamiento deficiente de los org\u00e1nulos celulares afectados.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Otro subgrupo, los trastornos de almacenamiento lisosomal (LSD), afectan colectivamente a 1 de cada 5.000 nacidos vivos, siendo la enfermedad de Fabry y la de Gaucher las m\u00e1s prevalentes.<sup>2,3,4<\/sup>&nbsp;Se estima que cada 20 minutos nace un ni\u00f1o con un LSD heredado.<\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">CENTOGENE ha desarrollado m\u00faltiples biomarcadores espec\u00edficos para ciertas enfermedades de <sup>almacenamiento<\/sup> lisosomal (LSD) con opciones terap\u00e9uticas. Por ejemplo, Lyso-Gb1 se ha identificado como el biomarcador m\u00e1s eficaz para la enfermedad de Gaucher.\u2075 Todos los an\u00e1lisis se pueden realizar a partir de muestras de sangre seca con <sup>CentoCard\u00ae<\/sup> y ayudan al diagn\u00f3stico precoz, as\u00ed como al seguimiento de la progresi\u00f3n de la enfermedad y la monitorizaci\u00f3n terap\u00e9utica de un trastorno espec\u00edfico de la manera m\u00e1s eficaz.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Ensayo enzim\u00e1tico<\/th><th>Enfermedad\/s\u00edndrome<\/th><th>Tipo de enfermedad<\/th><th>M\u00e9todo de detecci\u00f3n<\/th><th>Gene<\/th><\/tr><\/thead><tbody><tr><td>beta-glucocerebrosidasa<\/td><td>enfermedad de Gaucher<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>GBA<\/em><\/td><\/tr><tr><td>alfa-galactosidasa<\/td><td>Enfermedad de Fabry<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>GLA<\/em><\/td><\/tr><tr><td>alfa-glucosidasa<\/td><td>Enfermedad de Pompe<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>Asociaci\u00f3n Gay-George<\/em><\/td><\/tr><tr><td>alfa-L-iduronidasa<\/td><td>S\u00edndrome de Hurler (MPS I)<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>IDUA<\/em><\/td><\/tr><tr><td>iduronato-2-sulfatasa<\/td><td>S\u00edndrome de Hunter (MPS II)<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>Identificaci\u00f3n<\/em><\/td><\/tr><tr><td>arilsulfatasa B<\/td><td>S\u00edndrome de Maroteaux-Lamy (MPS VI)<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>ARSB<\/em><\/td><\/tr><tr><td>beta-galactosidasa<\/td><td>S\u00edndrome de Morquio B (MPS IV B)<\/td><td>LSD<\/td><td>Tandem-MS<\/td><td><em>GLB1<\/em><\/td><\/tr><tr><td>lipasa \u00e1cida<\/td><td>Enfermedad de Wolman<\/td><td>LSD<\/td><td>Tandem-MS<\/td><td><em>LIPA<\/em><\/td><\/tr><tr><td>alfa-N-acetilglucosaminidasa<\/td><td>S\u00edndrome de Sanfilippo B (MPS III B)<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>NAGLU<\/em><\/td><\/tr><tr><td>beta-manosidasa<\/td><td>Beta-manosidosis<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>MANBA<\/em><\/td><\/tr><tr><td>alfa-fucosidasa<\/td><td>Fucosidosis<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>FUCA1<\/em><\/td><\/tr><tr><td>beta-glucuronidasa<\/td><td>S\u00edndrome de Sly (MPS VII)<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>GUSB<\/em><\/td><\/tr><tr><td>beta-hexosaminidasa<\/td><td>enfermedad de Tay-Sachs<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>HEXA<\/em><\/td><\/tr><tr><td>hexosaminidasa total<\/td><td>Enfermedad de Sandhoff<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>HEXB<\/em><\/td><\/tr><tr><td>alfa-N-acetilgalactosaminidasa<\/td><td>Enfermedad de Schindler\/Kanzaki<\/td><td>LSD<\/td><td>Fluorimetr\u00eda<\/td><td><em>NAGA<\/em><\/td><\/tr><tr><td>palmitoil-prote\u00edna-tioesterasa<\/td><td>Enfermedad de Santavuori-Haltia<\/td><td>NCL<\/td><td>Fluorimetr\u00eda<\/td><td><em>Presentaci\u00f3n 1<\/em><\/td><\/tr><tr><td>tripeptidil-peptidasa<\/td><td>Enfermedad de Jansky-Bielschowsky<\/td><td>NCL<\/td><td>Fluorimetr\u00eda<\/td><td><em>TPP1<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Biomarcador metab\u00f3lico<\/th><th>Enfermedad\/s\u00edndrome<\/th><th>Tipo de enfermedad<\/th><th>M\u00e9todo de detecci\u00f3n<\/th><th>Gene<\/th><\/tr><\/thead><tbody><tr><td>glucosilesfingosina (liso-Gb1)<\/td><td>enfermedad de Gaucher<\/td><td>LSD<\/td><td>Tandem-MS<\/td><td><em>GBA, PSAP<\/em><\/td><\/tr><tr><td>trihex\u00f3sido de lisoceramida (liso-Gb3)<\/td><td>Enfermedad de Fabry<\/td><td>LSD<\/td><td>Tandem-MS<\/td><td><em>GLA, PSAP<\/em><\/td><\/tr><tr><td>liso-SM-509<\/td><td>Enfermedad de Niemann-Pick tipo A\/B y tipo C<\/td><td>LSD<\/td><td>Tandem-MS<\/td><td><em>SMPD1, NPC1, NPC2<\/em><\/td><\/tr><tr><td>3-O-metildopa (3-OMD)<\/td><td>Deficiencia de AADC<\/td><td>neurol\u00f3gico<\/td><td>Tandem-MS<\/td><td><em>DDC<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Caso de \u00e9xito: Lyso-Gb1 como el biomarcador m\u00e1s eficaz para la enfermedad de Gaucher<\/h2>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Se ha identificado a Lyso-Gb1 como el biomarcador m\u00e1s preciso para la enfermedad de Gaucher (EG) <sup>\u2075<\/sup> . Con una sensibilidad y especificidad de 100% (v\u00e9ase m\u00e1s abajo), es el biomarcador \u00f3ptimo para un diagn\u00f3stico sensible y fiable de la EG. La evidencia obtenida a partir de datos de pacientes tambi\u00e9n demuestra que la cuantificaci\u00f3n de este biomarcador puede servir como indicador directo de la gravedad de la enfermedad y de la respuesta al tratamiento para el seguimiento de la <sup>EG.\u2075<\/sup><\/p>\n\n\n\n<h5 class=\"wp-block-heading\">CUANTIFICACI\u00d3N DE LYSO-GB1 EN PACIENTES Y PORTADORES DE GAUCHER<\/h5>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"802\" height=\"432\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene_genetic_testing_200414-biomarker-LYSO-GB1-QUANTIFICATION.webp\" alt=\"\" class=\"wp-image-3416\" srcset=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene_genetic_testing_200414-biomarker-LYSO-GB1-QUANTIFICATION.webp 802w, https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene_genetic_testing_200414-biomarker-LYSO-GB1-QUANTIFICATION-768x414.webp 768w\" sizes=\"auto, (max-width: 802px) 100vw, 802px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Sensibilidad 100% y especificidad 100% de Lyso-Gb1 que conducen a la m\u00e1xima precisi\u00f3n en la identificaci\u00f3n del paciente para un diagn\u00f3stico \u00f3ptimo.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">NIVELES DE LYSO-GB1 EN PACIENTES CON GAUCHER EN TRATAMIENTO (N=19, MEDIA \u0394T ENTRE T1-T5 = 6 SEMANAS)<\/h5>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"806\" height=\"393\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene_genetic_testing_200414-biomarker-LYSO-GB1-LEVELS.webp\" alt=\"\" class=\"wp-image-3415\" srcset=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene_genetic_testing_200414-biomarker-LYSO-GB1-LEVELS.webp 806w, https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/centogene_genetic_testing_200414-biomarker-LYSO-GB1-LEVELS-768x374.webp 768w\" sizes=\"auto, (max-width: 806px) 100vw, 806px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Los niveles de liso-Gb1 aumentan significativa y r\u00e1pidamente en el punto temporal t5 tras una interrupci\u00f3n forzada del tratamiento debido a la falta temporal de terapia de reemplazo enzim\u00e1tico. Por lo tanto, la liso-Gb1 demuestra su excelente capacidad para el seguimiento de la enfermedad de Gaucher.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">Referencias<\/h5>\n\n\n\n<p class=\"has-small-font-size wp-block-paragraph translation-block\"><sup>1.<\/sup> Pruebas de biomarcadores\/enzimas complementarias para apoyar la clasificaci\u00f3n de variantes desconocidas y pat\u00f3genas.<br> <sup>2<\/sup> Wittmann, Judit, et al. \u201eDetecci\u00f3n neonatal de trastornos de almacenamiento lisosomal en Hungr\u00eda.\u201c JIMD Reports-Case and Research Reports, 2012\/3. Springer, Berl\u00edn, Heidelberg, 2012. 117-125.<br> <sup>3<\/sup> Burlina, Alberto B., et al. \u201eDetecci\u00f3n neonatal de trastornos de almacenamiento lisosomal mediante espectrometr\u00eda de masas en t\u00e1ndem en el noreste de Italia.\u201c Journal of Inherited Metabolic Disease: Official Journal of the Society for the Study of Inborn Errors of Metabolism 41.2 (2018): 209-219.<br> <sup>4<\/sup> Platt, Frances M., et al. \u201eEnfermedades de almacenamiento lisosomal.\u201c Nature Reviews Disease Primers 4.1 (2018): 1-25.<br> <sup>5<\/sup> Elstein, Deborah, et al. \u201eReducciones en glucosilfingosina (liso-Gb1) en pacientes sin tratamiento previo y previamente tratados que reciben velaglucerasa alfa para la enfermedad de Gaucher tipo 1: Datos de ensayos cl\u00ednicos de fase 3.\u201c Gen\u00e9tica molecular y metabolismo 122.1-2 (2017): 113-120.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<h5 class=\"wp-block-heading\">Recursos<\/h5>\n\n\n\n<h4 class=\"wp-block-heading\">Enlaces \u00fatiles<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.centogene.com\/es\/diagnosticos\/areas-clinicas\/trastornos-metabolicos\/\" data-type=\"clinical-areas\" data-id=\"801\">Pruebas metab\u00f3licas<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocolor\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocaja tableicons\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h3 class=\"wp-block-heading translation-block\">Ordene CentoMetabolic <sup>\u00ae<\/sup> MOx<\/h3>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.centoportal.com\/order\/new\/products\/analysis-method?queryType=TEST&amp;query=centometabolic%20mox\">Ordene ahora<\/a><\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocaja tableicons\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h3 class=\"wp-block-heading\">Solicitar una prueba de biomarcadores\/enzimas<\/h3>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.centoportal.com\/order\/new\/products\/analysis-method?queryType=TEST&amp;productCategory=7\">Ordene ahora<\/a><\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocaja tableicons\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\n<h3 class=\"wp-block-heading\">Solicite una prueba de cartera MOx<\/h3>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.centoportal.com\/order\/new\/products\/analysis-method?queryType=TEST&amp;query=mox\">Ordene ahora<\/a><\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n<\/div>\n<\/div>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    transparente\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n<section class=\"bloque-personalizado bloque-cta-texto estilo-default\" >\n    <div class=\"container\"> \n                    <div class=\"image-wrapper\" style=\"background-image:url(https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/csm_centogene_transcriptomics_multiomics_offering_20230918_2800_4_892e5e6e08-1500x844.jpg)\">\n                <!--<img decoding=\"async\" class=\"\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/02\/csm_centogene_transcriptomics_multiomics_offering_20230918_2800_4_892e5e6e08-1500x844.jpg\" alt=\"CentoXome MOx 2.0 Including RNA Sequencing Is Now Available\" \/>-->\n            <\/div>\n                <div class=\"row\">\n                        <div class=\"col-12 col-md-6 animation fadeLeft text-wrapper\">\n                <p class=\"bl-pretitulo\">MOx 2.0<\/p>                <div class=\"bl-titulo\">CentoXome MOx 2.0, que incluye secuenciaci\u00f3n de ARN, ya est\u00e1 disponible<\/div>\n\n                <p class=\"bl-texto\">Todos los beneficios y calidad de CentoGenome en solo 5 d\u00edas h\u00e1biles<\/p>                                <div class=\"mt-0 mb-3\">\n                    <a href=\"https:\/\/www.centoportal.com\/order\/new\/products\/analysis-method?queryType=TEST&#038;query=CentoGenome%20MOx%202.0&#038;productCategory=11\"\n                     target=\"_blank\"     \n                    class=\"btn btn-primary animation opacity delay-2\">Descubra m\u00e1s<\/a>\n                <\/div>\n                            <\/div>\n                    <\/div> \n    <\/div>  \n<\/section>\n\n<\/div>\r\n          \r\n                            \r\n        <\/div>\r\n    <\/div>\r\n<\/section>\r\n\n\n\r\n    \r\n\r\n<section class=\"bloque-contenedor    fondocolor\"   id=\"\">\r\n    <div class=\"container\">\r\n        <div class=\"\"> \r\n                                \r\n\r\n                <div class=\"acf-innerblocks-container\">\n\r\n\r\n\r\n<section class=\"bloque-tabs-resources\" id=\"tabs-group-920\">\r\n<h2 class=\"text-center mt-0\">Recursos relacionados<\/h2>\r\n    <div class=\"tab-content\" id=\"tab-content\">\r\n        <div class=\"acf-innerblocks-container\">\r\n                        \r\n            <div class=\"tab-link\"  id=\"tab-link-downloads-920\" >\r\n                <a href=\"#tab-body-downloads-920\"  data-id=\"920\">\r\n                    Descargas                <\/a>\r\n            <\/div>\r\n            \r\n\r\n                        <div class=\"tab-body  bloque-noticias bloque-tabs-resources-downloads\" id=\"tab-body-downloads-920\" >\r\n            <div  class=\"row\">                        <article class=\"col-xl-4 col-md-6 col-12\">\r\n                        <div class=\"row bl-texto\">\r\n                            <div class=\"bl-datos col-md-3 col-3\"> \r\n                                                                <img decoding=\"async\" src=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2023\/10\/CentoXome_MOx_Case_Study_Niemann-Pick-Disease_V1.4eng_20230801-pdf-400x400.jpg\" alt=\"CentoXome MOx diagnosticado con enfermedad de Niemann-Pick tipo C1\" class=\"file-thumbnail\">\r\n                                                            <\/div>\r\n                            <div class=\"col-md-9 col-9\">       \r\n\r\n                                <h4 class=\"bl-titulo\">CentoXome MOx diagnosticado con enfermedad de Niemann-Pick tipo C1<\/h4>\r\n                                \r\n                                <div class=\"bl-description\">\r\n                                <p>Demostrando el poder del enfoque multi\u00f3mico de CENTOGENE para un diagn\u00f3stico r\u00e1pido y concluyente<\/p>                                <\/div>\r\n                                \r\n                                <div class=\"bl-links\">\r\n                                                                    <a href=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2023\/10\/CentoXome_MOx_Case_Study_Niemann-Pick-Disease_V1.4eng_20230801.pdf\" target=\"_blank\" class=\"btn 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2022<\/time>                                     <\/div>\r\n                                    <div class=\"bl-topics\"><a href=\"https:\/\/www.centogene.com\/es\/topic\/multiomics\/\" class=\"cat-link\">Multi\u00f3mica<\/a><a href=\"https:\/\/www.centogene.com\/es\/topic\/metabolic-disorders\/\" class=\"cat-link\">Trastornos metab\u00f3licos<\/a><a href=\"https:\/\/www.centogene.com\/es\/topic\/wes\/\" class=\"cat-link\">Oeste<\/a><a href=\"https:\/\/www.centogene.com\/es\/topic\/wgs\/\" class=\"cat-link\">WGS<\/a><\/div>  \r\n                                    <a href=\"https:\/\/www.centogene.com\/es\/webinar\/mox-advancing-rare-disease-patient-care-with-multiomic-solutions\/\" rel=\"bookmark\" title=\"MOx: Impulsando la atenci\u00f3n a pacientes con enfermedades raras con soluciones multi\u00f3micas\" class=\"btn btn-2\">Mira ahora<\/a>\r\n\r\n                                <\/div>\r\n                            <\/div>\r\n                        <\/article>\r\n                  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Pilar Guatibonza, Clinical Genetic Liaison CENTOGENE, y el Dr. Carlos Manrique, Gerente Regional de Ventas en M\u00e9xico CENTOGENE, discuten el poder del NUEVO CentoXome en el entorno del diagn\u00f3stico cl\u00ednico y comparten conocimientos sobre los \u00faltimos \u00e9xitos de diagn\u00f3stico a trav\u00e9s de nuestros \u00faltimos estudios de casos.                                    <div class=\"bl-fecha\">\r\n                                     <time class=\"updated\" datetime=\"2021-11-30\" pubdate>30 de noviembre de 2021<\/time>                                     <\/div>\r\n                                    <div class=\"bl-topics\"><a href=\"https:\/\/www.centogene.com\/es\/topic\/biomarker\/\" class=\"cat-link\">Biomarcador<\/a><a href=\"https:\/\/www.centogene.com\/es\/topic\/metabolic-disorders\/\" class=\"cat-link\">Trastornos metab\u00f3licos<\/a><\/div>  \r\n                                    <a href=\"https:\/\/www.centogene.com\/es\/webinar\/new-centoxome-convirtiendo-nuestra-experiencia-en-su-ventaja\/\" rel=\"bookmark\" title=\"NUEVO CentoXome\u00ae: convirtiendo nuestra experiencia en su ventaja\" class=\"btn btn-2\">Mira ahora<\/a>\r\n\r\n                                <\/div>\r\n                            <\/div>\r\n                        <\/article>\r\n                                    \r\n                    <div class=\"text-center\">\r\n                                            <a href=\"\/es\/recursos\/seminarios-web\/\" class=\"btn btn-primary\">Ver todos los seminarios web<\/a>\r\n                                        <\/div>\r\n\r\n                <\/div>                   \r\n\r\n            <\/div>\r\n            \r\n\r\n\r\n                        <div class=\"tab-link\"  id=\"tab-link-publications-920\" >\r\n                <a href=\"#tab-body-publications-920\"  data-id=\"920\">\r\n                    Publicaciones cient\u00edficas                <\/a>\r\n            <\/div>\r\n\r\n           \r\n            <div class=\"tab-body bloque-noticias\" id=\"tab-body-publications-920\" >\r\n                <div  class=\"row\">                            <article class=\"col-xl-4 col-md-6 col-12\">\r\n                                <div class=\"item-noticia\">\r\n                                    <div class=\"bl-texto\">       \r\n                \r\n                                    <h4 class=\"bl-titulo\">Una enciclopedia para la lipid\u00f3mica por espectrometr\u00eda de masas<\/h4>\r\n                                    <p><strong>La espectrometr\u00eda de masas (EM) es una t\u00e9cnica de vanguardia para identificar y cuantificar especies lip\u00eddicas. Este estudio analiz\u00f3 esta herramienta para allanar el camino hacia una mejor investigaci\u00f3n y mejores resultados en salud para pacientes de todo el mundo.<\/strong><\/p>\r\n                                                                        \r\n                                   \r\n\r\n                                                                        <div class=\"bl-fecha\">\r\n                                         <time class=\"updated\" datetime=\"2022-06-23\" pubdate>23 de junio de 2022<\/time>                                     <\/div>\r\n                                    <div class=\"bl-topics\"><a href=\"https:\/\/www.centogene.com\/es\/topic\/multiomics\/\" class=\"cat-link\">Multi\u00f3mica<\/a><a href=\"https:\/\/www.centogene.com\/es\/topic\/metabolic-disorders\/\" class=\"cat-link\">Trastornos metab\u00f3licos<\/a><a href=\"https:\/\/www.centogene.com\/es\/topic\/biodatabank\/\" class=\"cat-link\">Banco de biodatos<\/a><\/div>  \r\n                                                    \r\n                                        <a href=\"https:\/\/www.mdpi.com\/2218-1989\/12\/7\/584\/htm\" rel=\"bookmark\" title=\"Una enciclopedia para la lipid\u00f3mica por espectrometr\u00eda de masas\" class=\"btn btn-2\" target=\"_blank\">Leer publicaci\u00f3n <\/a>\r\n                                                                        <\/div>\r\n                                <\/div>\r\n                            <\/article>\r\n                                                <article class=\"col-xl-4 col-md-6 col-12\">\r\n                                <div class=\"item-noticia\">\r\n                                    <div class=\"bl-texto\">       \r\n                \r\n                                    <h4 class=\"bl-titulo\">Un enfoque multi\u00f3mico para diagnosticar pacientes y acelerar los tratamientos<\/h4>\r\n                                    <p><strong>Un enfoque que integra pruebas gen\u00e9ticas y bioqu\u00edmicas como herramienta de diagn\u00f3stico de primera l\u00ednea para pacientes con trastornos metab\u00f3licos hereditarios.<\/strong><\/p>\r\n                                                                        \r\n                                   \r\n\r\n                                                                            <div class=\"bl-autores\">\r\n                                        Autor(es): Bertoli-Avella, Aida M., MD                                        <\/div>\r\n                                                                        <div class=\"bl-fecha\">\r\n                                         <time class=\"updated\" datetime=\"2022-06-22\" pubdate>22 de junio de 2022<\/time>                                     <\/div>\r\n                                    <div class=\"bl-topics\"><a href=\"https:\/\/www.centogene.com\/es\/topic\/biomarker\/\" class=\"cat-link\">Biomarcador<\/a><a href=\"https:\/\/www.centogene.com\/es\/topic\/metabolic-disorders\/\" class=\"cat-link\">Trastornos metab\u00f3licos<\/a><a href=\"https:\/\/www.centogene.com\/es\/topic\/multiomics\/\" class=\"cat-link\">Multi\u00f3mica<\/a><\/div>  \r\n                                                    \r\n                                        <a href=\"https:\/\/www.centogene.com\/wp-content\/uploads\/2025\/03\/CentoMetabolic_MOx_Publication_202206_Web_20220623.pdf\" rel=\"bookmark\" title=\"Un enfoque multi\u00f3mico para diagnosticar pacientes y acelerar los tratamientos\" class=\"btn btn-2\" target=\"_self\">Leer publicaci\u00f3n (PDF)<\/a>\r\n                                                                        <\/div>\r\n                                <\/div>\r\n                            <\/article>\r\n                                                <article class=\"col-xl-4 col-md-6 col-12\">\r\n                                <div class=\"item-noticia\">\r\n                                    <div class=\"bl-texto\">       \r\n                \r\n                                    <h4 class=\"bl-titulo\">Mayor aplicabilidad de los biomarcadores de enfermedades raras<\/h4>\r\n                                    <p><strong>Cuantificaci\u00f3n de un perfil urinario de biomarcadores en pacientes con enfermedad de Gaucher tipo 1 mediante espectrometr\u00eda de masas en t\u00e1ndem<\/strong><\/p>\r\n                                                                        \r\n                                   \r\n\r\n                                                                            <div class=\"bl-autores\">\r\n                                        Autor(es): Curado, Filipa                                        <\/div>\r\n                                                                        <div class=\"bl-fecha\">\r\n                                         <time class=\"updated\" datetime=\"2022-06-8\" pubdate>08 de junio de 2022<\/time>                                     <\/div>\r\n                                    <div 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