Somatic Mutation Testing

Molecular profiling is critical for identifying and characterizing unique somatic variants that accumulate in cancer cells. We offer analytical tests for somatic variants in tumor tissue that can help to identify diagnostic, prognostic or predictive biomarkers.

Next-generation sequencing is becoming more widely adopted as a valuable method for somatic mutation analysis in cancer. CENTOGENE offers hotspot targeted mutation analysis, selective sequencing of gene regions, single gene sequencing and panel testing for the analysis of dozens of cancer-related genes in parallel.

Search our test catalogue

Overview of single gene tests for somatic mutations

Gene test	Associated cancer types	Test methods available	How to order
BRAF	xnon-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small-cell lung carcinoma, and lung adenocarcinoma	a. Hot spot targeted mutation testing b. Selective sequencing of exon 15 c. Single gene sequencing d. Panel testing	order a test
CALR	Myeloproliferative neoplasms, including myelofibrosis, essential thrombocythemia	a. Selective sequencing of exon 9 b. Panel testing	order a test
EGFR	Non-small-cell lung cancer	a. Hotspot targeted mutation testing b. Exons 18-21 testing c. Panel testing	order a test
IDH1	Lower grade diffuse gliomas (grade II–III), secondary glioblastomas, diagnosed glioblastomas, acute myeloid leukemia (AML), central nervous cancer	a. Selective sequencing of exon 4 b. Single gene sequencing c. Panel testing	order a test
IDH2	Acute myeloid leukemia (AML), gliomas	a. Selective sequencing of exon 4 b. Single gene sequencing c. Panel testing	order a test
JAK2	Acute lymphoblastic leukemia (ALL), polycythemia vera, thrombocythemia and idiopathic myelofibrosis	a. Selective sequencing of exons 12,14 and 16 b. Single gene sequencing c. Panel testing	order a test
KIT	Gastrointestinal stromal tumors (GISTs), acute myeloid leukemia (AML)	a. Selective sequencing of exons 8,9,11,13 and 17 b. Single gene sequencing c. Panel testing	order a test
KRAS	Colorectal cancer	a. Hotspot targeted mutation testing b. Single gene sequencing c. Panel testing	order a test
NRAS	Colorectal cancer	a. Hotspot targeted mutation testing b. Single gene sequencing c. Panel testing	order a test

Our portfolio for somatic mutation testing

Panels

Filter

Single Gene Analysis

Filter

Scientific articles on somatic mutations

Robustness of Comprehensive DNA- and RNA-Based Assays at Diagnosis of Acute Myeloid Leukemia Using Blood and Bone Marrow Stored on Filter Cards

"Molecular analyses in hematologic malignancies gained considerable importance in the last decade at diagnosis and for minimal residual disease (MRD). In our study, we performed a comparison of state-of-the-art…

Article Jul 13, 2016 with topic Hematology, Oncology, CentoCard®

Read more

Single-Variant-Specific, Single-Gene-Specific and Panel Diagnostics for Somatic Mutations in Tumors

Somatic Mutation Testing

Search our test catalogue

Overview of single gene tests for somatic mutations

Our portfolio for somatic mutation testing

Panels

Single Gene Analysis

Scientific articles on somatic mutations

Robustness of Comprehensive DNA- and RNA-Based Assays at Diagnosis of Acute Myeloid Leukemia Using Blood and Bone Marrow Stored on Filter Cards

Get in touch with our Partner Support

Our consultation service is available in several languages.

+49 (0) 381 - 80113 416

Mon. – Fri. 7 a.m.– 8 p.m. CET • Sat. 9 a.m. – 5 p.m. CET

For our US Partners:

+1 (617) 580-2102

Mon. – Fri. 9 a.m. – 5:30 p.m. EST