Doctor and woman look down

Single-Variant-Specific, Single-Gene-Specific and Panel Diagnostics for Somatic Mutations in Tumors

CENTOGENE's somatic mutation tests are highly sensitive, easy to use, and accurate for identifying even low frequency variants successfully.

Order a test  Learn more

Somatic Mutation Testing

Molecular profiling is critical for identifying and characterizing unique somatic variants that accumulate in cancer cells.

We offer analytical tests for somatic variants in tumor tissue that can help to identify diagnostic, prognostic or predictive biomarkers.

Next-generation sequencing is becoming more widely adopted as a valuable method for somatic mutation analysis in cancer. CENTOGENE offers hotspot targeted mutation analysis, selective sequencing of gene regions, single gene sequencing and panel testing for the analysis of dozens of cancer-related genes in parallel.

Visit Our Online Ordering Portal

CentoPortal® is a user-friendly, online, web-based ordering portal designed to assist you at every step of processing your patients' samples.

Go to CentoPortal

CENTOGENE CentoPortal Logo

Overview of single gene tests for somatic mutations

Gene test

Associated cancer types

Test methods available

How to order

BRAF

xnon-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small-cell lung carcinoma, and lung adenocarcinoma

a. Hotspot targeted mutation testing*

b. Selective sequencing of exon 15

c. Single gene sequencing

d. Panel testing

order a test

CALR

Myeloproliferative neoplasms, including myelofibrosis, essential thrombocythemia

a. Selective sequencing of exon 9

b. Panel testing

order a test

EGFR Non-small-cell lung cancer

a. Hotspot targeted mutation testing*

b. Exons 18-21 testing

c. Panel testing

 

order a test

IDH1 Lower grade diffuse gliomas (grade II–III), secondary glioblastomas, diagnosed glioblastomas, acute myeloid leukemia (AML), central nervous cancer

a. Selective sequencing of exon 4

b. Single gene sequencing

c. Panel testing

order a test

IDH2 Acute myeloid leukemia (AML), gliomas

a. Selective sequencing of exon 4

b. Single gene sequencing

c. Panel testing

order a test

JAK2 Acute lymphoblastic leukemia (ALL), polycythemia vera, thrombocythemia and idiopathic myelofibrosis 

a. Selective sequencing of exons 12,14 and 16

b. Single gene sequencing

c. Panel testing

order a test

KIT Gastrointestinal stromal tumors (GISTs), acute myeloid leukemia (AML)

a. Selective sequencing of exons 8,9,11,13 and 17

b. Single gene sequencing

c. Panel testing

order a test

KRAS Colorectal cancer

a. Hotspot targeted mutation testing*

b. Single gene sequencing

c. Panel testing

order a test

NRAS Colorectal cancer

a. Hotspot targeted mutation testing*

b. Single gene sequencing

c. Panel testing

order a test

*Note: Hotspot targeted mutation testing is unavailable in the US for the following mutations: BRAF c.1799T>A p.V600E, EGFR c.2573T>G, p.L858R, KRAS c.35G>A, p.G12D, KRAS c.38G>A, p.G13D, KRAS c.35G>T p.G12V, NRAS c.181C>A p.Q61K, NRAS c.34G>T, p.G12C, NRAS c.35G>A, p.G12D, NRAS c.182A>G, p.Q61R.

Resources

Scientific Publications

Mechanistic Insights Into Cancer Predisposition

Genetic predisposition to cancer is tightly linked to an increased rate of somatic mutations. For one of the corresponding syndromes, the underlying defect has now been revealed to affect the DNA […]

Article
Aug 26, 2020
  • Mutation Database
  • Oncology
Loading...

Understanding DNA Alterations in Colorectal Cancer

Germline and somatic DNA alterations may cause inherited diseases and/or cancer. While CENTOGENE’s routine diagnostic focus is on the former, we frequently address oncological questions in research […]

Article
Dec 18, 2019
  • Oncology
  • WES
Loading...

Genetic modifiers in hereditary breast cancer

Age at manifestation varies widely in carriers of cancer susceptibility variants. A recent study involving scientists from CENTOGENE suggested that this phenomenon is partially explained by certain […]

Article
Aug 07, 2019
  • Oncology
  • Mutation Database
Loading...
CENTOGENE Holding the Hand of an Elderly Lady

Myeloid Tumor Panel

Genetic testing for myeloid tumor at CENTOGENE can provide you with valuable information for diagnostic decisions, prognosis, therapeutic approaches and patient counseling

Learn more

Get in Touch With Our Customer Support

Our consultation service is available in several languages.

+49 (0) 381 80 113 - 416

Mon. – Fri. 7 a.m. – 8 p.m. CEST

Sat. 8 a.m. – 12 p.m. CEST

Contact Us

For our US Partners:

+1 (617) 580 - 2102

Mon. – Fri. 9 a.m. – 5:30 p.m. EST


Contact Us