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Genetic Diagnosis of Hereditary Cancer
Testing for hereditary cancers can detect specific, heritable, disease-related gene mutations that may increase the risk of certain cancers allowing an in-depth cancer risk assessment for each patient.
The critical goal is to detect cancer early and to give you the opportunity to maximize health outcomes for your patients. Patient-tailored screening programs, preventive measures and proactive treatment are possible for patients of a high-risk group. Early diagnosis can mean a better overall prognosis through a choice of surgical and non-surgical treatment options.
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Scientific articles
Breast and ovarian cancer
Breast cancer is one of the most common cancers in the world affecting ~12.5% of women during their lifetime. 5–10% of these patients have a hereditary form.
Mutations in the BRCA1 and BRCA2 genes are the most common hereditary cause. However, other genes such as ATM, BRIP1, CHEK2, PALB2, RAD51, etc. have also been associated with increased risk.
Gene test: | BRCA1/BRCA2 panel | CentoBreast® |
|---|---|---|
| Gene name: | BRCA1, BRCA2 | ABRAXAS1, ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, DICER1, EPCAM, FANCC, MEN1, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PALB2, PMS1, PMS2, PTEN, RAD50, RAD51C, RAD51D, RECQL, SMARCA4, STK11, TP53, XRCC2 |
Diseases covered: | Breast cancer | Breast cancer, ovarian cancer |
| Turnaround time: | 15 business days | 15 business days |
| How to order: | Order a test | Order a test |
Comprehensive cancer panel
CentoCancer® is a specific and sensitive panel with all known highly penetrant cancer genes.
Each gene has been carefully selected based on its risk potential in the development of one of the following cancers: breast, ovarian, colorectal, gastric, bowel, endometrial, pancreatic, melanoma, renal and prostate cancer.
Gene test: | CentoCancer® |
|---|---|
| Genes name: | ABRAXAS1, APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, DICER1, DIS3L2, EPCAM, FANCC, FH, FLCN, GALNT12, HNF1B, HOXB13, KIT, MC1R, MEN1, MET, MITF, MLH1, MLH3, MRE11, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS1, PMS2, POLD1, POLE, POT1, PRSS1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, RNF43, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, TGFBR2, TP53, TSC1, TSC2, VHL, WT1, XRCC2, XRCC3 |
| Diseases covered: | Breast, ovarian, colorectal, gastric, bowel, endometrial, pancreatic, melanoma, renal and prostate cancer |
| Turnaround time: | 15 business days |
| How to order: | Order a test |
DOWNLOADS FOR CENTOCANCER®
Portfolio for hereditary cancer
Single Gene Analysis
Filter
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Basal cell nevus syndrome
PTCH1 -
Basal cell nevus syndrome
SUFU -
Basal cell nevus syndrome due to germline PTCH2 mutation
PTCH2 -
Beckwith-Wiedemann syndrome
CDKN1C -
Beckwith-Wiedemann syndrome
chr. 11p15 -
Beckwith-Wiedemann syndrome
H19 -
Beckwith-Wiedemann syndrome
KCNQ1OT1 -
Breast cancer, male, susceptibility to
BRCA2 -
Breast cancer, RINT1 related
RINT1 -
Breast cancer, susceptibility to
BARD1 -
Breast cancer, susceptibility to
PALB2 -
Breast cancer, susceptibility to
RECQL -
Breast cancer, susceptibility to
XRCC3 -
Breast-ovarian cancer
BRCA1 -
Breast-ovarian cancer
RAD51C -
Breast-ovarian cancer, familial, susceptibility to, type 4
RAD51D -
Breast-ovarian cancer, familial, type 2
BRCA2 -
Carcinoid tumors, intestinal
SDHD -
Carney complex type 1
PRKAR1A -
Cell cycle disorder, CDC20 related
CDC20 -
Colorectal cancer, hereditary
NRAS -
Colorectal cancer, hereditary nonpolyposis type 1
MSH2 -
Colorectal cancer, hereditary nonpolyposis type 2
MLH1 -
Colorectal cancer, hereditary nonpolyposis type 4
PMS2 -
Colorectal cancer, hereditary nonpolyposis type 5
MSH6 -
Colorectal cancer, hereditary nonpolyposis type 6
TGFBR2 -
Colorectal cancer, hereditary nonpolyposis type 7
MLH3 -
Colorectal cancer, hereditary nonpolyposis type 8
EPCAM -
Colorectal cancer, hereditary, susceptibility to
CCND1 -
Cowden syndrome type 1
PTEN -
Cowden syndrome type 3
SDHD -
Cowden syndrome type 5
PIK3CA -
Cowden syndrome type 6
AKT1 -
Cutaneous telangiectasia and cancer syndrome, familial
ATR -
Cylindromatosis, familial
CYLD -
Desmoid disease, hereditary
APC -
Endometrial cancer, familial, MSH6 related
MSH6 -
Familial adenomatous polyposis coli
APC -
Familial adenomatous polyposis type 2
MUTYH -
Familial adenomatous polyposis type 3
NTHL1 -
Familial adenomatous polyposis type 4
MSH3 -
Gastric cancer, hereditary diffuse
CDH1 -
Gastrointestinal stromal tumor, familial
KIT -
Glioblastoma type 3, susceptibility to, due to BRCA2 germline mutation
BRCA2 -
Granulomatous disease, chronic, autosomal recessive, cytochrome b- positive, type 1
NCF1 -
Hemangioma capillary infantile
ANTXR1 -
Hemangioma, capillary infantile, familial, susceptibility to
KDR -
Hereditary breast and ovarian cancer syndrome, RAD50 related
RAD50 -
Hereditary Retinoblastoma
RB1 -
Hurthle cell thyroid carcinoma, due to germline NDUFA13 mutation
NDUFA13 -
Juvenile myelomonocytic leukemia, due to CBL germline mutation
CBL -
Juvenile polyposis syndrome
BMPR1A -
Juvenile polyposis syndrome
SMAD4 -
Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome
SMAD4 -
Leukemia, acute lymphoblastic, susceptibility to, due to PAX5 germline mutation
PAX5 -
Leukemia, acute promyelocytic, PL2F/RARA type
ZBTB16 -
Leukemia, myeloid acute form, due to CEBPA germline mutation
CEBPA -
Li-Fraumeni syndrome type 1
TP53 -
Li-Fraumeni syndrome type 2
CHEK2 -
Medulloblastoma, desmoplastic, familial
SUFU -
Medulloblastoma, due to BRCA2 germline mutation
BRCA2 -
Melanoma and neural system tumor syndrome, familial
CDKN2A -
Melanoma, cutaneous malignant
MC1R -
Melanoma, cutaneous malignant
MITF -
Melanoma, cutaneous malignant, familial
CDKN2A -
Melanoma, cutaneous malignant, familial type 6, susceptibility to
XRCC3 -
Melanoma, cutaneous malignant, familial type 10, susceptibility to
POT1 -
Melanoma, cutaneous malignant, familial, CDK4 related
CDK4 -
Meningioma, familial, PDGFB related
PDGFB -
Meningioma, familial, susceptibility to
SMARCE1 -
Meningioma, familial, susceptibility to
SUFU -
Meningioma, MN1 deficiency related
MN1 -
Mismatch repair cancer syndrome
MLH1 -
Mismatch repair cancer syndrome
MSH2 -
Mismatch repair cancer syndrome
MSH6 -
Mismatch repair cancer syndrome
PMS2 -
MMR genes methylation analysis
MMR genes -
Muir-Torre syndrome
MLH1 -
Muir-Torre syndrome
MSH2 -
Multiple endocrine neoplasia type 1, CDKN2B related
CDKN2B -
Multiple endocrine neoplasia type 2A
RET -
Multiple endocrine neoplasia type 2B
RET -
Multiple endocrine neoplasia type 4
CDKN1B -
Myxoma, intracardiac
PRKAR1A -
Neurofibromatosis type 1 -like syndrome
SPRED1 -
Neurofibromatosis type 1
NF1 -
Neurofibromatosis type 2
NF2 -
Nonpolyposis hereditary colon cancer, PMS1 related
PMS1 -
Nonsmall cell lung cancer, familial, susceptibility to
EGFR -
Pancreatic cancer type 2, susceptibility to
BRCA2 -
Pancreatic cancer type 3, susceptibility to
PALB2 -
Pancreatic cancer, susceptibility to, type 4
BRCA1 -
Pancreatic cancer/melanoma syndrome, familial
CDKN2A -
Paraganglioma and gastric stromal sarcoma
SDHD -
Paraganglioma and gastric stromal sarcoma
SDHD -
Paragangliomas type 1, with or without deafness
SDHD -
Paragangliomas type 4
SDHB -
Paragangliomas type 5
SDHA -
Peutz-Jeghers syndrome
STK11 -
Pheochromocytoma type 1
SDHD -
Pheochromocytoma type 2
SDHB -
Pheochromocytoma type 3
SDHC -
Pheochromocytoma type 5
SDHAF2 -
Pheochromocytoma type 8
TMEM127 -
Pheochromocytoma type 9
MAX -
Pituitary adenoma, ACTH-secreting, due to AIP germline mutation
AIP -
Pituitary adenoma, growth hormone-secreting, due to AIP germline mutation
AIP -
Pituitary adenoma, prolactin-secreting, due to AIP germline mutation
AIP -
Pleuropulmonary blastoma
DICER1 -
Polyposis syndrome, hereditary mixed
GREM1 -
Polyposis syndrome, hereditary mixed type 2
BMPR1A -
Prostate cancer
BRCA2 -
Prostate cancer
STAG1 -
Prostate cancer
ZNF783 -
Prostate cancer, familial, association with
HOXB13 -
Prostate cancer, hereditary type 1
RNASEL -
Prostate cancer, hereditary type 2, susceptibility to
ELAC2 -
Renal cell carcinoma, due to HNF1A germline mutation
HNF1A -
Renal cell carcinoma, papillary type 1, familial
MET -
RET, selective sequencing of exons 5, 8, 10, 11 and 13-16
RET -
Spiegler-Brooke syndrome
CYLD -
Thyroid cancer type 2, nonmedullary, susceptibility to
SRGAP1 -
Trichoepithelioma, multiple familial, type 1
CYLD -
Tumor predisposition syndrome
BAP1 -
Tumor predisposition syndrome, ARL11 related
ARL11 -
Tylosis with esophageal cancer
RHBDF2 -
von Hippel-Lindau syndrome
VHL -
Wilms tumor, familial, due to BRCA2 mutation
BRCA2 -
Spiegler-Brooke syndrome
CYLD -
Thyroid cancer type 2, nonmedullary, susceptibility to
SRGAP1 -
Trichoepithelioma, multiple familial, type 1
CYLD -
Tumor predisposition syndrome
BAP1 -
Tumor predisposition syndrome, ARL11 related
ARL11 -
Tylosis with esophageal cancer
RHBDF2 -
von Hippel-Lindau syndrome
VHL -
Wilms tumor, familial, due to BRCA2 mutation
BRCA2