Newsletter 5/2012

Parkinson disease


Dear ###USER_title1### ###USER_last_name###,

Parkinson disease (PD) affects about 3% of individuals above 65 years of age. It is becoming increasingly clear that genetic factors contribute to its complex pathogenesis. About 5% of PD cases are caused by a single gene and show Mendelian inheritance. Centogene offers genetic diagnostic testing for all ten established PD-causing genes.

Recent data from basic research suggest that mitochondrial dysfunction plays a central role in clinically similarearly-onset autosomal recessive forms of PD, caused by PARKIN, PINK1 and possibly DJ-1 gene mutations. Furthermore, alpha-synuclein accumulation in Lewy bodies defines a spectrum of disorders ranging from typical late-onset PD to PD dementia, due to mutations in SCNA and LRRK2. Fascinating data about the association between Gaucher disease and Parkinson disease has emerged in the last two years.

Centogene collaborates with a broad network of distinguished neurogeneticists, such as Prof. Christine Klein, Head of the Section of Clinical and Molecular Neurogenetics, University of Lübeck, Germany.

If you would like to benefit from our expertise in neurogenetics, please feel free to contact us.

Centogene offers testing for the ten genes so far identified which cause Parkinson disease:



Best regards,

Doreen Niemann
Senior Director Strategic Communication
Centogene AG


Centogene AG
Schillingallee 68
18057 Rostock


Responsible: Doreen Niemann
USt-IdNr.: DE813228872