Centogene - The Rare Disease Company


I am an experienced neurogeneticist, and moved back to Lebanon from the US wanting to make a
difference in the diagnosis, care and prevention of recurring neurogenetic disorders in the Lebanese.

Alas, I was only partially successful, sometimes suspecting certain diagnoses, and caring for these kids to the best of my ability. I suspected rare diagnoses, but could rarely prove them and felt particularly frustrated when a second case recurred in the same family. 

This was the case up to 2013 (i.e. BC or Before CentoGene).

And then there was light, and, life began again (i.e. AC or After Centogene).

My positive diagnostic rate has gone up from 15% using just CGH microarray to 80% using targeted
sequencing and whole exome sequencing.

I am now able to do proper, informed genetic counseling.  Parents can finally stop searching for a diagnosis and answer the painful question …..’but what does my child actually have?’

More importantly, we have helped at least a half dozen families in 2015 go through successful pregnancies and birth of healthy babies, worry-free, anticipating happy outcomes.

Together with Centogene, we have prevented the recurrence of a case of metachromatic leukodystrophy, another with familial spastic paraplegia 15, CLN2 disease or late infantile neuronal ceroid lipofuscinoses, and the list goes on. It may seem like a drop in the bucket to you, but it means the world for families
concerned. None of this would have been remotely possible without the excellent diagnostic services and thorough follow-up provided by the scientists and clinicians at Centogene.

The icing on the cake was visiting Centogene in Rostock. I attended the outstanding WES master class at CentoAcademy.  There, I had the privilege of accompanying the voyage of lonely blood spots from a
distraught family in Lebanon, to DNA extraction, whole exome sequencing, and state of the art
bioinformatic analysis, and finally, accurate diagnosis. 

 I interacted with wonderful human beings, outstanding teachers, scientists and clinicians at Centogene who generously shared their time, theoretical and applied knowledge and skills. Attending this master class should be imperative for anyone in the field of neurology and genetics. I recommend it highly.

Rose-Mary Boustany



Rose-Mary Boustany, Professor of Pediatrics and Adolescent Medicine, American University of Beirut
Medical Center
Beirut, January 2016

Thank you very much for your unlimited help and support."
Saudi-Arabia, December 2015

"I received your letter, read it thoroughly and enjoyed. After that, I took a look at your site which was
fantastic for me and gained a lot of information. My major is Medical Biotechnology. So, I will be happy to be able to work with you."
Iran, December 2015

“Thank you very much for the result in the name of the family. Your very fast response is highly appreciated.”
Dubai, December 2015

Bravo to you and your team for the spectacular effort in getting this report against a looming deadline.
My warmest thanks to all.
Dr. Willie Reardon, Consultant Clinical Geneticist, Our Lady's Hospital for Sick Children, Dublin, Ireland
November 2015

I really appreciate your excellent efforts.
Many Thanks
Doha-Qatar, November 2015

I am writing to thank you for the extended testing you provided for our patient.
We did not think of repeating the sequencing of the same gene before, since it was performed in a
well-established laboratory.
With your results, we will be able to plan for a prenatal with confidence.
Turkey, November 2015

„I would like to congratulate you and your team for the exome report on my patient. This was a very
puzzling case and the patient had seen many doctors. I am very happy that Centogene was able to identify the mutation. Since its present in father and daughter who are symptomatic and not in the mother would tend to support that it is pathogenic.
Please convey my congratulations and thanks to your staff.“
Dr. I. C. Verma, Sir Ganga Ram Hospital, India, November 2015

"Thank you very much indeed for your fast and professional service. We greatly appreciate it. I am glad there is such an organisation as yourself."
Turkey, November 2015

"Speaking on behalf of my group, we enjoy and very much value the service your lab provides and plan to do so going forward.  Thank you for all that you do!"
US, November 2015

"Thank you so much for your help and quick response."
US, October 2015

"As always I was very happy with the service provided by Centogene."
Australia, January 2015

"Every time, in any situation you help & guide me, even by cell phone, I thank & appreciate it so much."
Iran, January 2015

"This was a most comprehensive and prompt response to a question that I only asked yesterday. Thank you so much. I am very impressed and grateful."
South Africa, September 2014

"So far I sent one question through the site and got a prompt answer, not even 48 hours. Very nice! Thank you."
Georgia, August 2014

"Thank you so much for your reply! My life just got a little bit easier..."
Stockholm, Sweden, June 2014

"I appreciate very much your excellent kind of service, accuracy and your active team was very cooperative helping in diagnosis of our patients and offering hope to them. Thank you so much."
Cairo, Egypt, May 2014

"Your lab identified a BRCA2 mutation and she is fortunate enough now to have preventative options offered to her. I truly appreciated your help in this case."
Doha, Qatar, April 2014

"We used your services and found it at high level and very professional. We also found your filtercards very easy to use."
Rome, Italy, February 2014

"The patient, the family and me are very grateful with you and your lab that fill our hopes with your excellent services, both from the point of view of high-quality, scientific support and human values in this case. We are grateful for the time given, excellent communication, great understanding, sympathy and solidarity. THANK YOU!"
La Paz, Bolivia, January 2014

"A huge thank you to you and your wonderful team for getting this to me today.  I look forward to working with you again soon"
Canada, January 2014

"As always I was very happy with the service provided by Centogene."
Sydney, Australia, January 2014

"Centogene has provided a good service, as this is pretty rapid in terms of genetic tests (single gene
analysis). They have been splendid."
Brisbane, Australia, January 2014

"I started using Cento a few months ago and am very satisfied with your services: prompt response and
excellent turnaround time and full service. Keep up the good work."
Beirut, Lebanon, January 2014

"Keep up the good work"
India, January 2014

Benefit from our neurogenetics network. Centogene cooperates with the Institute for Human Genetics of the University of Tübingen, the Department of Neurogenetics at the Clinic for Neurology of the University of Lübeck and the Albrecht-Kossel-Institute for Neuroregeneration.

Prof. Arndt Rolfs MD Chief Medical Director

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