Determining Copy Number Variations in DNA Quickly and Efficient With CentoArray™
Comparative genomic hybridization is a molecular cytogenetic method for analyzing copy number
variations. CGH array allows us to quickly and efficiently determine the relative abundance of nucleic acid sequences in the target sample. The method utilizes a large number of short stretches of synthetic DNA that probe for various genomic loci dispersed throughout the genome. Target DNA sample is labeled and hybridized with the DNA probes spotted on a solid array surface. Based on the relative amount of probe hybridized to each target spot, information is gained about the abundance of specific nucleic acid sequences within the sample. The major advantage of high density genomic arrays in detecting structural aberrations is that they can provide information on thousands of targets in a single experiment that can
resolve any copy number changes ranging from gene, chromosome to genome level. Typically, high number of probes in the coding region of genes backed by backbone probes in the non-coding regions enables detection of not only previously described but also novel alterations in regions of interest. When copy number probes are combined with SNP probes in high density, additional information on mosaicism, loss of heterozygosity (LOH) and uniparental disomy (UPD) can be gained.
Discover our CentoArray™ Microarray solutions:
Advantages of our CentoArray™ solutions
- Highest resolution of chromosomal aberrations at the genome level
- Short turnaround time (15 working days)
- Highest performance with a wide range of sample types including formalin fixed paraffin embedded (FFPE) specimen
- Offered at an attractive price, CentoArray™ is a cost effective alternative to MLPA and qPCR when
analyzing multiple genes simultaneously
- CAP, CLIA and ISO accreditation
If you have any questions, please do not hesitate to contact us directly.
Please note: Prenatal testing is not offered in the US.