Network of Expertise
Renowned medical professionals who’s knowledge contributes from a large variety of disciplines provides medical and genetic insights through leadership in their respective fields of expertise. This will further strengthen Centogene’s drive to bridging the gap between genetic testing and medical interpretation.
Prof. Matthias Löhr MD
Scientific Advisory Board (Speaker)
Dr. Matthias Löhr is professor of gastroenterology & hepatology. He studied Medicine in Würzburg, Hamburg, Loma Linda, Chicago and Basel (1980-86). After his MD thesis and internship in pathology, he completed a postdoc with Dr. M.B.A. Oldstone at Scripps Clinic & Research Foundation, La Jolla, CA. In 1989, he began his residency in Internal Medicine at the Univ. of Erlangen, Bavaria.
In 1993 became chief resident at the Dept. of Medicine, Univ. of Rostock, where he also completed his training in
gastroenterology. His habilitation was on pancreatic cancer (1996).
In 2000, he became professor of Molecular Gastroenterology at the Univ. of Heidelberg, Mannheim Medical Faculty, and in 2003 was appointed Head of the Div. of Molecular Gastroenterology at the German Cancer Research Center (DKFZ). He was part of the steering group that established the National Center for Tumor
Diseases (NCT) in Heidelberg and program director for the
German GI society oncology program (DGVS) 2004-2007. In 2007, he became Professor of gastroenterology and hepatology at Karolinska Institute, Sweden.
Dr. Löhr’s in-depth experience focuses on pancreatic diseases, ranging from chronic autoimmune pancreatitis to pancreatic
cancer and cystic tumors. He is a member of a large consortium whose goal is to identify novel genetic markers in (chronic)
pancreatitis and he also leads the Swedish surveillance program for patients with familiar pancreatic cancer. He has held several positions as PI on early-phase clinical trials in pancreatic cancer (CT-PCA-1; EndoTAG-1; AXP-001), and is currently PI on a study of personalized cancer medicine in pancreatic cancer (PePaCaKa) using NGS and evidence-based software. Dr. Löhr has published over 200 scientific papers and represents the United European Gastroenterology (UEG) in Brussels where he participates in several activities, e.g. the Biomed Alliance and the Multi-stakeholder Platform for Pancreatic Cancer.
Prof. Gheona Altarescu MD
Scientific Advisory Board
Gheona Altarescu obtained her magna cum laude diploma in Medicine at the Jassy University of Medicine and Pharmacy,
Romania. She performed her training in medical genetics at the National Institutes of Health, Bethesda, USA during the years 1997 to 2000 under the supervision of Dr. Roscoe Brady.
During this period of time she treated more than 100 patients with
different lysosomal storage diseases: Gaucher disease type I , II and III, Fabry disease, Mucolipidosis type IV, Hunter and Hurler disease and performed basic molecular research in the field of lysosomal storage disorders. She is board certified in clinical and molecular genetics.
Upon returning to Israel she established the Preimplantation
Genetic Diagnosis Clinic and Lysosomal diseases Clinic at the Shaare Zedek Medical Center in Jerusalem. The clinic is the largest of its kind in Israel and performed preimplantation genetic diagnosis for more than 300 different genetic disorders including lysosomal storage diseases (Gaucher, Fabry and Hunter
syndrome) resulting in the birth of 400 healthy children since the year 2005. She has been involved in clinical trials for different drugs for both Gaucher type I and Fabry disease. Gheona Altarescu has published almost 100 peer reviewed papers in the field of lysosomal diseases and preimplantation genetic diagnosis and is currently Associate Professor of Genetics at Hebrew
University Hadassah Medical School, Jerusalem and the Director of the Preimplantation Genetic Unit and Lysosomal diseases Clinic at Shaare Zedek Medical Center, Jerusalem.
Prof. Christine Klein MD
Scientific Advisory Board
Dr. Christine Klein is a Professor of Neurology and
Neurogenetics. She studied medicine in Hamburg, Heidelberg, Luebeck (1988-1994), and London (with Dr. N.P. Quinn in 1994/1995).
She moved to Boston from 1997-1999 for a fellowship in
Molecular Neurogenetics under the mentorship of Dr. X.O. Breakefield.
Dr. Klein completed her neurology training at Luebeck University with Dr. D. Koempf in 2004, followed by a series of summer
sabbaticals in movement disorders with Dr. A.E. Lang in Toronto, Canada in 2004-2013.
She was appointed Lichtenberg Professor at the Department of Neurology of Luebeck University in 2005, where her research has focused on the clinical and molecular
genetics of movement disorders and its functional consequences. In 2009, Dr. Klein has been awarded a Schilling Section of
Clinical and Molecular Neurogenetics at the University of Luebeck and has become Director of the newly founded Institute of
Neurogenetics in 2013.
Dr. Klein has published over 300 scientific papers and is the 2008 recipient of the Derek Denny-Brown Award of the American
Neurological Association. She is an Associate Editor of
‘Movement Disorders’ and a member of the editorial board of ‘Neurology’. She is head of the Neurogenetics Working Group of the German Neurological Society and a member of the standing committee of the Neuroscience Study Section of the German
Research Foundation and of the scientific advisory board of the Bachmann-Strauss Dystonia & Parkinson Foundation, as well as chair of the Congress Scientific Program Committee of the 2016/2017 Annual Congresses of the International Parkinson and Movement Disorder Society.
Prof. Christine Klein, MD
Schilling Professor of Neurogenetics and Neurology
Director of the Institute of Neurogenetics
University of Luebeck
Prof. Markus M. Lerch MD FRCP
Scientific Advisory Board
Markus M. Lerch is a professor of medicine at the University of Greifswald and Chairman of the Department of Medicine A at the University Hospital. He majored in Philosophy and Art History at the University of Freiburg before attending Medical School in Freiburg, Glasgow, Toronto and at the University of
He received his MD (magna cum laude) from Freiburg in 1984 for experimental studies on the pathophysiology of the exocrine
pancreas. After a Pathology Internship in Freiburg he completed a residency in Internal Medicine at the Technical University of Aachen. On a DFG research scholarship he spend three years at Harvard and the University of Milano, Italy, where he was trained in pathophysiology and cell biology. After a GI fellowship in Ulm and his board certification in Gastroenterology (1993), he
obtained a second doctorate (Habiliation, PhD equivalent) in 1994 for work on the cell biology of pancreatitis from the University of Ulm. He then moved to the Max-Planck-Institut for Biochemistry in Munich to join the Molecular Biology Department of Axel Ullrich as a staff scientist and was board certified in Biochemistry. After serving as an assistant professor and consultant
gastroenterologist in Homburg (Saar), and as tenured associate professor at the University of Münster (1997-2003) he accepted a professorship at the University of Greifswald (founded in 1456) where he was appointed chairman of the Department of Medicine A in 2007.
The research of his group focusses on the pathophysiology, cell biology and genetics of pancreatic disorders and is by design translational. His research has been supported by the European Union (EU-FP7, EU-EFRE), the DFG (German Research
Council), the BMBF (German Federal Ministry of Science and
Education) and the Deutsche Krebshilfe/Mildred Scheel Stiftung (German Cancer Aid) as well as several foundations and
charities. The implementation of this bench-to-bedside strategy found its way into three investigator initiated clinical trials (e.g.
ISRCTN 00142233 & ISRCTN 46556454) and facilitated several patent applications and patents (e.g. EP06776693.1, EP10164624, EP11167708), particularly in the area of biomarker development. Prof. Lerch is an elected Study Section member (Grants Committee of the German Research Council DFG) since 2008 and was appointed by President of the Federal Republic to serve on the ‘Council of Science and Humanities’
(Wissenschaftsrat) of the German government in 2015.